IL-18 and cutaneous inflammatory diseases

Ji Hyun Lee; Dae Ho Cho; Hyun Jeong Park

doi:10.3390/ijms161226172

IL-18 and cutaneous inflammatory diseases

Ji Hyun Lee
, Dae Ho Cho
, Hyun Jeong Park

Department of Dermatology

Research output: Contribution to journal › Review article › peer-review

85 Scopus citations

Abstract

Interleukin (IL)-18, an IL-1 family cytokine, is a pleiotropic immune regulator. IL-18 plays a strong proinflammatory role by inducing interferon (IFN)-γ. Previous studies have implicated IL-18 in the pathogenesis of various diseases. However, it is not well understood biologic activities of IL-18 in the diverse skin diseases. Here, we have reviewed the expression and function of IL-18 in skin diseases including inflammatory diseases. This article provides an evidence-based understanding of the role of IL-18 in skin diseases and its relationship with disease activities.

Original language	English
Pages (from-to)	29357-29369
Number of pages	13
Journal	International Journal of Molecular Sciences
Volume	16
Issue number	12
DOIs	https://doi.org/10.3390/ijms161226172
State	Published - 9 Dec 2015

Bibliographical note

Publisher Copyright:
© 2015 by the authors; licensee MDPI, Basel, Switzerland.

Keywords

Alopecia areata
Atopic dermatitis
Contact dermatitis
Drug eruption
Fibrosis
Graft-versus-host disease
IL-18
Lupus erythematosus
Psoriasis
Skin disease
Skin tumor
Urticaria

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title = "IL-18 and cutaneous inflammatory diseases",

abstract = "Interleukin (IL)-18, an IL-1 family cytokine, is a pleiotropic immune regulator. IL-18 plays a strong proinflammatory role by inducing interferon (IFN)-γ. Previous studies have implicated IL-18 in the pathogenesis of various diseases. However, it is not well understood biologic activities of IL-18 in the diverse skin diseases. Here, we have reviewed the expression and function of IL-18 in skin diseases including inflammatory diseases. This article provides an evidence-based understanding of the role of IL-18 in skin diseases and its relationship with disease activities.",

keywords = "Alopecia areata, Atopic dermatitis, Contact dermatitis, Drug eruption, Fibrosis, Graft-versus-host disease, IL-18, Lupus erythematosus, Psoriasis, Skin disease, Skin tumor, Urticaria",

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month = dec,

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doi = "10.3390/ijms161226172",

language = "English",

volume = "16",

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TY - JOUR

T1 - IL-18 and cutaneous inflammatory diseases

AU - Lee, Ji Hyun

AU - Cho, Dae Ho

AU - Park, Hyun Jeong

PY - 2015/12/9

Y1 - 2015/12/9

N2 - Interleukin (IL)-18, an IL-1 family cytokine, is a pleiotropic immune regulator. IL-18 plays a strong proinflammatory role by inducing interferon (IFN)-γ. Previous studies have implicated IL-18 in the pathogenesis of various diseases. However, it is not well understood biologic activities of IL-18 in the diverse skin diseases. Here, we have reviewed the expression and function of IL-18 in skin diseases including inflammatory diseases. This article provides an evidence-based understanding of the role of IL-18 in skin diseases and its relationship with disease activities.

AB - Interleukin (IL)-18, an IL-1 family cytokine, is a pleiotropic immune regulator. IL-18 plays a strong proinflammatory role by inducing interferon (IFN)-γ. Previous studies have implicated IL-18 in the pathogenesis of various diseases. However, it is not well understood biologic activities of IL-18 in the diverse skin diseases. Here, we have reviewed the expression and function of IL-18 in skin diseases including inflammatory diseases. This article provides an evidence-based understanding of the role of IL-18 in skin diseases and its relationship with disease activities.

KW - Alopecia areata

KW - Atopic dermatitis

KW - Contact dermatitis

KW - Drug eruption

KW - Fibrosis

KW - Graft-versus-host disease

KW - IL-18

KW - Lupus erythematosus

KW - Psoriasis

KW - Skin disease

KW - Skin tumor

KW - Urticaria

UR - https://www.scopus.com/pages/publications/84949908373

U2 - 10.3390/ijms161226172

DO - 10.3390/ijms161226172

M3 - Review article

C2 - 26690141

AN - SCOPUS:84949908373

SN - 1661-6596

VL - 16

SP - 29357

EP - 29369

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 12

ER -

IL-18 and cutaneous inflammatory diseases

Abstract

Bibliographical note

Keywords

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