Imaging Characteristics of Brain SPECT, PET, and MRI in Neurosyphilis

Eun Kyoung Choi; Young Do Kim; Hyeonseok Jeong; Yong An Chung; Jin Kyoung Oh; In Uk Song

doi:10.1007/s13139-021-00684-9

Imaging Characteristics of Brain SPECT, PET, and MRI in Neurosyphilis

Eun Kyoung Choi
, Young Do Kim
, Hyeonseok Jeong
, Yong An Chung
, Jin Kyoung Oh
, In Uk Song

The Catholic University of Korea Incheon St. Mary's Hospital

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The incidence of neurosyphilis has declined since effective penicillin therapy against Treponema pallidum was introduced. However, the diagnosis of neurosyphilis early in the disease course is very important in order to select appropriate antibiotic therapy. We report brain MRI, SPECT with Tc-99m ECD, and PET with F-18 FDG findings before antibiotic therapy in a neurosyphilis patient with neurological symptoms. The cerebral cortices showed hypoperfusion with a patchy distribution on SPECT and foci with high signal intensity on MRI, suggesting ischemia. Brain PET showed areas with hypometabolism in the temporoparietal lobes bilaterally.

Original language	English
Pages (from-to)	48-51
Number of pages	4
Journal	Nuclear Medicine and Molecular Imaging
Volume	55
Issue number	1
DOIs	https://doi.org/10.1007/s13139-021-00684-9
State	Published - Feb 2021

Bibliographical note

Publisher Copyright:
© 2021, Korean Society of Nuclear Medicine.

Keywords

Magnetic resonance imaging
Neurosyphilis
Positron-emission tomography
Tomography, emission-computed, single-photon

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10.1007/s13139-021-00684-9

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title = "Imaging Characteristics of Brain SPECT, PET, and MRI in Neurosyphilis",

abstract = "The incidence of neurosyphilis has declined since effective penicillin therapy against Treponema pallidum was introduced. However, the diagnosis of neurosyphilis early in the disease course is very important in order to select appropriate antibiotic therapy. We report brain MRI, SPECT with Tc-99m ECD, and PET with F-18 FDG findings before antibiotic therapy in a neurosyphilis patient with neurological symptoms. The cerebral cortices showed hypoperfusion with a patchy distribution on SPECT and foci with high signal intensity on MRI, suggesting ischemia. Brain PET showed areas with hypometabolism in the temporoparietal lobes bilaterally.",

keywords = "Magnetic resonance imaging, Neurosyphilis, Positron-emission tomography, Tomography, emission-computed, single-photon",

author = "Choi, \{Eun Kyoung\} and Kim, \{Young Do\} and Hyeonseok Jeong and Chung, \{Yong An\} and Oh, \{Jin Kyoung\} and Song, \{In Uk\}",

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T1 - Imaging Characteristics of Brain SPECT, PET, and MRI in Neurosyphilis

AU - Choi, Eun Kyoung

AU - Kim, Young Do

AU - Jeong, Hyeonseok

AU - Chung, Yong An

AU - Oh, Jin Kyoung

AU - Song, In Uk

PY - 2021/2

Y1 - 2021/2

N2 - The incidence of neurosyphilis has declined since effective penicillin therapy against Treponema pallidum was introduced. However, the diagnosis of neurosyphilis early in the disease course is very important in order to select appropriate antibiotic therapy. We report brain MRI, SPECT with Tc-99m ECD, and PET with F-18 FDG findings before antibiotic therapy in a neurosyphilis patient with neurological symptoms. The cerebral cortices showed hypoperfusion with a patchy distribution on SPECT and foci with high signal intensity on MRI, suggesting ischemia. Brain PET showed areas with hypometabolism in the temporoparietal lobes bilaterally.

AB - The incidence of neurosyphilis has declined since effective penicillin therapy against Treponema pallidum was introduced. However, the diagnosis of neurosyphilis early in the disease course is very important in order to select appropriate antibiotic therapy. We report brain MRI, SPECT with Tc-99m ECD, and PET with F-18 FDG findings before antibiotic therapy in a neurosyphilis patient with neurological symptoms. The cerebral cortices showed hypoperfusion with a patchy distribution on SPECT and foci with high signal intensity on MRI, suggesting ischemia. Brain PET showed areas with hypometabolism in the temporoparietal lobes bilaterally.

KW - Magnetic resonance imaging

KW - Neurosyphilis

KW - Positron-emission tomography

KW - Tomography, emission-computed, single-photon

UR - https://www.scopus.com/pages/publications/85100533395

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DO - 10.1007/s13139-021-00684-9

M3 - Article

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SN - 1869-3474

VL - 55

SP - 48

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JO - Nuclear Medicine and Molecular Imaging

JF - Nuclear Medicine and Molecular Imaging

IS - 1

ER -

Imaging Characteristics of Brain SPECT, PET, and MRI in Neurosyphilis

Abstract

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Keywords

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