Abstract
Background: The aim of this study was to clarify the impact of infiltration pattern on prognosis in patients with gastric carcinoma invading subserosa. Methods: Clinicopathologic findings in patients with ssγ pattern (n = 144) were compared with those in patients with ssα/ssβ cancers (n = 222). Prognostic factors of pT2b patients were analyzed by univariate and multivariate analysis. Results: Compared with the ssα/β group, ssγ gastric cancer exhibited more frequent undifferentiated histology, disseminated lymph node metastasis and perineural invasion. Frequency of postoperative peritoneal recurrence was significantly higher in ssγ gastric cancer (P < 0.05). The 5-year survival rate for patients with ssγ gastric cancer was significantly lower compared with ssα/β group (63.2% vs. 74.8%, respectively; P < 0.05). Lymph node metastasis, vein invasion and infiltrative pattern (ssγ) were significant independent prognostic factors affecting survival in pT2b patients. Conclusion: In patients with gastric cancer invading the subserosa, infiltrative type growth pattern is closely related to carcinomatosis and poorer prognosis.
| Original language | English |
|---|---|
| Pages (from-to) | 563-567 |
| Number of pages | 5 |
| Journal | European Journal of Surgical Oncology |
| Volume | 36 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 2010 |
Bibliographical note
Funding Information:This study was partly supported by The Catholic Cancer Center .
Keywords
- Gastric cancer
- Infiltration pattern
- Peritoneal metastasis
- Prognosis
- Subserosal invasion
