In vitro and in vivo metabolism of myristicin in the rat

Hye Suk Lee; Tae Cheon Jeong; Jeong Han Kim

doi:10.1016/S0378-4347(97)00531-8

In vitro and in vivo metabolism of myristicin in the rat

Hye Suk Lee, Tae Cheon Jeong, Jeong Han Kim

Pharmacy

Korea Research Institute of Chemical Technology

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Myristicin [5-allyl-1-methoxy-2,3-(methylenedioxy)benzene] is a flavoring plant constituent and has been known to produce significant psychopharmacological responses as well as insecticidal activity. From in vitro and in vivo metabolism of myristicin, the two metabolites 5-allyl-1-methoxy-2,3-dihydroxybenzene and 1'-hydroxymyristicin were identified using GC-MS after derivatization of sample matrices with a mixture of BSTFA-TMCS. Those metabolites from in vitro study were also confirmed in urine after an oral administration of myrisitcin to rats, and enzymatic hydrolysis of urine suggested that these metabolites were excreted as conjugated forms as well.

Original language	English
Pages (from-to)	367-372
Number of pages	6
Journal	Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Volume	705
Issue number	2
DOIs	https://doi.org/10.1016/S0378-4347(97)00531-8
State	Published - 13 Feb 1998

Bibliographical note

Funding Information:
This paper was supported by Non Directed Research Fund, Korea Research Foundation, 1996.

Keywords

Myristicin

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10.1016/S0378-4347(97)00531-8

Cite this

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title = "In vitro and in vivo metabolism of myristicin in the rat",

abstract = "Myristicin [5-allyl-1-methoxy-2,3-(methylenedioxy)benzene] is a flavoring plant constituent and has been known to produce significant psychopharmacological responses as well as insecticidal activity. From in vitro and in vivo metabolism of myristicin, the two metabolites 5-allyl-1-methoxy-2,3-dihydroxybenzene and 1'-hydroxymyristicin were identified using GC-MS after derivatization of sample matrices with a mixture of BSTFA-TMCS. Those metabolites from in vitro study were also confirmed in urine after an oral administration of myrisitcin to rats, and enzymatic hydrolysis of urine suggested that these metabolites were excreted as conjugated forms as well.",

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AU - Jeong, Tae Cheon

AU - Kim, Jeong Han

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AB - Myristicin [5-allyl-1-methoxy-2,3-(methylenedioxy)benzene] is a flavoring plant constituent and has been known to produce significant psychopharmacological responses as well as insecticidal activity. From in vitro and in vivo metabolism of myristicin, the two metabolites 5-allyl-1-methoxy-2,3-dihydroxybenzene and 1'-hydroxymyristicin were identified using GC-MS after derivatization of sample matrices with a mixture of BSTFA-TMCS. Those metabolites from in vitro study were also confirmed in urine after an oral administration of myrisitcin to rats, and enzymatic hydrolysis of urine suggested that these metabolites were excreted as conjugated forms as well.

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In vitro and in vivo metabolism of myristicin in the rat

Abstract

Bibliographical note

Keywords

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