Incidental thyroid lesions detected by FDG-PET/CT: Prevalence and risk of thyroid cancer

Ja Seong Bae; Byung Joo Chae; Woo Chan Park; Jeong Soo Kim; Sung Hoon Kim; Sang Seol Jung; Byung Joo Song

doi:10.1186/1477-7819-7-63

Incidental thyroid lesions detected by FDG-PET/CT: Prevalence and risk of thyroid cancer

Ja Seong Bae
, Byung Joo Chae
, Woo Chan Park
, Jeong Soo Kim
, Sung Hoon Kim
, Sang Seol Jung
, Byung Joo Song

Department of Surgery

The Catholic University of Korea

Research output: Contribution to journal › Article › peer-review

108 Scopus citations

Abstract

Background: Incidentally found thyroid lesions are frequently detected in patients undergoing FDG-PET/CT. The aim of this study was to investigate the prevalence of incidentally found thyroid lesions in patients undergoing FDG-PET/CT and determine the risk for thyroid cancer. Methods: FDG-PET/CT was performed on 3,379 patients for evaluation of suspected or known cancer or cancer screening without any history of thyroid cancer between November 2003 and December 2005. Medical records related to the FDG-PET/CT findings including maximum SUV(SUVmax) and pattern of FDG uptake, US findings, FNA, histopathology received by operation were reviewed retrospectively. Results: Two hundred eighty five patients (8.4%) were identified to have FDG uptake on FDG-PET/CT. 99 patients with focal or diffuse FDG uptake underwent further evaluation. The cancer risk of incidentally found thyroid lesions on FDG-PET/CT was 23.2% (22/99) and the cancer risks associated with focal and diffuse FDG uptake were 30.9% and 6.4%. There was a significant difference in the SUV_max between the benign and malignant nodules (3.35 ± 1.69 vs. 6.64 ± 4.12; P < 0.001). There was a significant correlation between the SUVmax and the size of the cancer. Conclusion: The results of this study suggest that incidentally found thyroid lesions by FDG-PET/CT, especially a focal FDG uptake and a high SUV, have a high risk of thyroid malignancy. Further diagnostic work-up is needed in these cases.

Original language	English
Article number	63
Journal	World Journal of Surgical Oncology
Volume	7
DOIs	https://doi.org/10.1186/1477-7819-7-63
State	Published - 10 Aug 2009

Bibliographical note

Funding Information:
This manuscript was supported by a grant from research fund donated by Gangneung Dong-In hospital.

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@article{0833b107dd9f4553acc45212df829e64,

title = "Incidental thyroid lesions detected by FDG-PET/CT: Prevalence and risk of thyroid cancer",

abstract = "Background: Incidentally found thyroid lesions are frequently detected in patients undergoing FDG-PET/CT. The aim of this study was to investigate the prevalence of incidentally found thyroid lesions in patients undergoing FDG-PET/CT and determine the risk for thyroid cancer. Methods: FDG-PET/CT was performed on 3,379 patients for evaluation of suspected or known cancer or cancer screening without any history of thyroid cancer between November 2003 and December 2005. Medical records related to the FDG-PET/CT findings including maximum SUV(SUVmax) and pattern of FDG uptake, US findings, FNA, histopathology received by operation were reviewed retrospectively. Results: Two hundred eighty five patients (8.4\%) were identified to have FDG uptake on FDG-PET/CT. 99 patients with focal or diffuse FDG uptake underwent further evaluation. The cancer risk of incidentally found thyroid lesions on FDG-PET/CT was 23.2\% (22/99) and the cancer risks associated with focal and diffuse FDG uptake were 30.9\% and 6.4\%. There was a significant difference in the SUVmax between the benign and malignant nodules (3.35 ± 1.69 vs. 6.64 ± 4.12; P < 0.001). There was a significant correlation between the SUVmax and the size of the cancer. Conclusion: The results of this study suggest that incidentally found thyroid lesions by FDG-PET/CT, especially a focal FDG uptake and a high SUV, have a high risk of thyroid malignancy. Further diagnostic work-up is needed in these cases.",

author = "Bae, \{Ja Seong\} and Chae, \{Byung Joo\} and Park, \{Woo Chan\} and Kim, \{Jeong Soo\} and Kim, \{Sung Hoon\} and Jung, \{Sang Seol\} and Song, \{Byung Joo\}",

note = "Funding Information: This manuscript was supported by a grant from research fund donated by Gangneung Dong-In hospital.",

year = "2009",

month = aug,

day = "10",

doi = "10.1186/1477-7819-7-63",

language = "English",

volume = "7",

journal = "World Journal of Surgical Oncology",

issn = "1477-7819",

publisher = "BioMed Central Ltd.",

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TY - JOUR

T1 - Incidental thyroid lesions detected by FDG-PET/CT

T2 - Prevalence and risk of thyroid cancer

AU - Bae, Ja Seong

AU - Chae, Byung Joo

AU - Park, Woo Chan

AU - Kim, Jeong Soo

AU - Kim, Sung Hoon

AU - Jung, Sang Seol

AU - Song, Byung Joo

N1 - Funding Information: This manuscript was supported by a grant from research fund donated by Gangneung Dong-In hospital.

PY - 2009/8/10

Y1 - 2009/8/10

N2 - Background: Incidentally found thyroid lesions are frequently detected in patients undergoing FDG-PET/CT. The aim of this study was to investigate the prevalence of incidentally found thyroid lesions in patients undergoing FDG-PET/CT and determine the risk for thyroid cancer. Methods: FDG-PET/CT was performed on 3,379 patients for evaluation of suspected or known cancer or cancer screening without any history of thyroid cancer between November 2003 and December 2005. Medical records related to the FDG-PET/CT findings including maximum SUV(SUVmax) and pattern of FDG uptake, US findings, FNA, histopathology received by operation were reviewed retrospectively. Results: Two hundred eighty five patients (8.4%) were identified to have FDG uptake on FDG-PET/CT. 99 patients with focal or diffuse FDG uptake underwent further evaluation. The cancer risk of incidentally found thyroid lesions on FDG-PET/CT was 23.2% (22/99) and the cancer risks associated with focal and diffuse FDG uptake were 30.9% and 6.4%. There was a significant difference in the SUVmax between the benign and malignant nodules (3.35 ± 1.69 vs. 6.64 ± 4.12; P < 0.001). There was a significant correlation between the SUVmax and the size of the cancer. Conclusion: The results of this study suggest that incidentally found thyroid lesions by FDG-PET/CT, especially a focal FDG uptake and a high SUV, have a high risk of thyroid malignancy. Further diagnostic work-up is needed in these cases.

AB - Background: Incidentally found thyroid lesions are frequently detected in patients undergoing FDG-PET/CT. The aim of this study was to investigate the prevalence of incidentally found thyroid lesions in patients undergoing FDG-PET/CT and determine the risk for thyroid cancer. Methods: FDG-PET/CT was performed on 3,379 patients for evaluation of suspected or known cancer or cancer screening without any history of thyroid cancer between November 2003 and December 2005. Medical records related to the FDG-PET/CT findings including maximum SUV(SUVmax) and pattern of FDG uptake, US findings, FNA, histopathology received by operation were reviewed retrospectively. Results: Two hundred eighty five patients (8.4%) were identified to have FDG uptake on FDG-PET/CT. 99 patients with focal or diffuse FDG uptake underwent further evaluation. The cancer risk of incidentally found thyroid lesions on FDG-PET/CT was 23.2% (22/99) and the cancer risks associated with focal and diffuse FDG uptake were 30.9% and 6.4%. There was a significant difference in the SUVmax between the benign and malignant nodules (3.35 ± 1.69 vs. 6.64 ± 4.12; P < 0.001). There was a significant correlation between the SUVmax and the size of the cancer. Conclusion: The results of this study suggest that incidentally found thyroid lesions by FDG-PET/CT, especially a focal FDG uptake and a high SUV, have a high risk of thyroid malignancy. Further diagnostic work-up is needed in these cases.

UR - https://www.scopus.com/pages/publications/69549120057

U2 - 10.1186/1477-7819-7-63

DO - 10.1186/1477-7819-7-63

M3 - Article

C2 - 19664272

AN - SCOPUS:69549120057

SN - 1477-7819

VL - 7

JO - World Journal of Surgical Oncology

JF - World Journal of Surgical Oncology

M1 - 63

ER -

Incidental thyroid lesions detected by FDG-PET/CT: Prevalence and risk of thyroid cancer

Abstract

Bibliographical note

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