Abstract
To identify whether vascular endothelial growth factor receptor (VEGFR)-3, a receptor for VEGF-C and VEGF-D, is involved in pathophysiology of stroke, we investigated the spatiotemporal regulation of VEGFR-3 mRNA after transient focal cerebral ischemia. Most of the increase in VEGFR-3 expression in the ischemic core could be attributed to brain macrophages, whereas VEGFR-3 in the peri-infarct penumbra region was predominantly expressed in reactive astrocytes. A subpopulation of VEGFR-3-expressing brain macrophages was positive for NG2 proteoglycan and showed proliferative activity. In addition, in vitro model of stroke revealed no significant induction of VEGFR-3 in activated microglial cells, indicating that infiltrating exogenous macrophages expressed VEGFR-3 after focal ischemia. These data suggest that VEGFR-3 may be involved in the glial reaction and possibly in the recruitment of monocytic macrophages during ischemic insults.
| Original language | English |
|---|---|
| Pages (from-to) | 81-90 |
| Number of pages | 10 |
| Journal | Journal of Neuroimmunology |
| Volume | 229 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - 15 Dec 2010 |
Bibliographical note
Funding Information:This work was supported by the Korea healthcare technology R&D project, Ministry for Health, Welfare and Family Affairs (grant number: A08-4288-0902-0000100 ) and by a scholarship from Seoul Science Fellowship, Seoul City (Shin, Y-J).
Keywords
- Astrocytes
- Brain macrophages
- Focal ischemia
- Ischemic core
- Peri-infarct penumbra zone