Inertial blood plasma separation in a contraction-expansion array microchannel

Myung Gwon Lee; Sungyoung Choi; Hee Je Kim; Hee Kyun Lim; Joon Ho Kim; Nam Huh; Je Kyun Park

doi:10.1063/1.3601745

Inertial blood plasma separation in a contraction-expansion array microchannel

Myung Gwon Lee, Sungyoung Choi, Hee Je Kim, Hee Kyun Lim, Joon Ho Kim, Nam Huh, Je Kyun Park

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

Continuous inertial blood plasma separation is demonstrated in a contraction-expansion array microchannel with a low aspect ratio (AR). The separation cutoff value of the particle size can be controlled by modulation of the force balance between inertial lift and Dean drag forces. The modulation is achieved by changing the channel AR at contraction region, which causes the change in magnitudes of the inertial lift forces on the particles. The presented blood plasma separator provides a level of yield and throughput of 62.2% and 1.2 ml/h (∼1.0× 10⁸ cells/min), respectively.

Original language	English
Article number	253702
Journal	Applied Physics Letters
Volume	98
Issue number	25
DOIs	https://doi.org/10.1063/1.3601745
State	Published - 20 Jun 2011

Bibliographical note

Funding Information:
This research was supported by Samsung Advanced Institute of Technology (SAIT), by the National Research Laboratory (NRL) Program (Grant No. R0A-2008-000-20109-0), and by the Converging Research Center Program (Grant No. 2009-0093663) through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (MEST).

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abstract = "Continuous inertial blood plasma separation is demonstrated in a contraction-expansion array microchannel with a low aspect ratio (AR). The separation cutoff value of the particle size can be controlled by modulation of the force balance between inertial lift and Dean drag forces. The modulation is achieved by changing the channel AR at contraction region, which causes the change in magnitudes of the inertial lift forces on the particles. The presented blood plasma separator provides a level of yield and throughput of 62.2% and 1.2 ml/h (∼1.0× 108 cells/min), respectively.",

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AU - Lee, Myung Gwon

AU - Choi, Sungyoung

AU - Kim, Hee Je

AU - Lim, Hee Kyun

AU - Kim, Joon Ho

AU - Huh, Nam

AU - Park, Je Kyun

N1 - Funding Information: This research was supported by Samsung Advanced Institute of Technology (SAIT), by the National Research Laboratory (NRL) Program (Grant No. R0A-2008-000-20109-0), and by the Converging Research Center Program (Grant No. 2009-0093663) through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (MEST).

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N2 - Continuous inertial blood plasma separation is demonstrated in a contraction-expansion array microchannel with a low aspect ratio (AR). The separation cutoff value of the particle size can be controlled by modulation of the force balance between inertial lift and Dean drag forces. The modulation is achieved by changing the channel AR at contraction region, which causes the change in magnitudes of the inertial lift forces on the particles. The presented blood plasma separator provides a level of yield and throughput of 62.2% and 1.2 ml/h (∼1.0× 108 cells/min), respectively.

AB - Continuous inertial blood plasma separation is demonstrated in a contraction-expansion array microchannel with a low aspect ratio (AR). The separation cutoff value of the particle size can be controlled by modulation of the force balance between inertial lift and Dean drag forces. The modulation is achieved by changing the channel AR at contraction region, which causes the change in magnitudes of the inertial lift forces on the particles. The presented blood plasma separator provides a level of yield and throughput of 62.2% and 1.2 ml/h (∼1.0× 108 cells/min), respectively.

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Inertial blood plasma separation in a contraction-expansion array microchannel

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