Influence of genetic polymorphisms on the association between phthalate exposure and pulmonary function in the elderly

Hye Yin Park; Jin Hee Kim; Youn Hee Lim; Sanghyuk Bae; Yun Chul Hong

doi:10.1016/j.envres.2012.11.004

Influence of genetic polymorphisms on the association between phthalate exposure and pulmonary function in the elderly

Hye Yin Park, Jin Hee Kim, Youn Hee Lim, Sanghyuk Bae, Yun Chul Hong

Department of Preventive Medicine

Seoul National University

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Background: Phthalates are prevalent environmental exposure chemicals with rising concern on various health effects, including pulmonary function. Meanwhile, elderly people are more susceptible to environmental exposure, and their decreasing lung function is an important health issue. Objectives: To investigate the association between urinary phthalate metabolite levels and indices for pulmonary function, and evaluate effect modification by genetic polymorphisms of oxidative-stress related genes, catalase (CAT), superoxide dismutase (SOD2), and myeloperoxidase (MPO) in elderly Koreans. Methods: We conducted a panel study on 418 individuals over 60 years old in Seoul, Korea, and repeatedly measured urinary phthalate metabolite levels and ran pulmonary function tests. Genetic polymorphisms of CAT (rs769218, rs769217), SOD2 (rs4880, rs2758331, rs5746136) and MPO (rs2071409, rs7208693) were determined. Mixed effect model was used to investigate association of phthalate levels with pulmonary function indices and to examine the effect of CAT, SOD2 and MPO polymorphisms on the association. Results: Inverse association was demonstrated between sum of mono-(2-ethyl-5-hydroxyhexyl) phthalate and mono-(2-ethyl-5-oxohexyl) phthalate (σDEHP) levels and FEV₁/FVC (Β=-0.632, p=0.0275) or FEF_25-75 (Β=-0.077, p=0.025) after adjusting for age, months after previous measurements, sex, body mass index, cotinine, mean temperature and dew point. The effect of σDEHP on lung function was significant only in subjects with certain genotypes, and having all significant genotypes in three genes showed significant difference in the phthalate-pulmonary function association (FEV₁/FVC: Β=-2.169, p=0.0032; FEF_25-75: Β=-0.155, p=0.0103), while other combinations showed less estimate size without any significance. Conclusions: Urinary phthalate metabolites levels are associated with decreasing pulmonary function in elderly Koreans, and effect modification of certain CAT, SOD2 and MPO polymorphisms on the association is suggested.

Original language	English
Pages (from-to)	18-24
Number of pages	7
Journal	Environmental Research
Volume	122
DOIs	https://doi.org/10.1016/j.envres.2012.11.004
State	Published - Apr 2013

Bibliographical note

Funding Information:
This study was supported by the Susceptible Population Research Program (2008–2010) of the Ministry of Environment and the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science and Technology (2011-0005907), Republic of Korea.

Keywords

Elderly
Genetic polymorphisms
Oxidation
Phthalates
Pulmonary function

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10.1016/j.envres.2012.11.004

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@article{9ff112c8642848e1b24ae89280fadb3a,

title = "Influence of genetic polymorphisms on the association between phthalate exposure and pulmonary function in the elderly",

abstract = "Background: Phthalates are prevalent environmental exposure chemicals with rising concern on various health effects, including pulmonary function. Meanwhile, elderly people are more susceptible to environmental exposure, and their decreasing lung function is an important health issue. Objectives: To investigate the association between urinary phthalate metabolite levels and indices for pulmonary function, and evaluate effect modification by genetic polymorphisms of oxidative-stress related genes, catalase (CAT), superoxide dismutase (SOD2), and myeloperoxidase (MPO) in elderly Koreans. Methods: We conducted a panel study on 418 individuals over 60 years old in Seoul, Korea, and repeatedly measured urinary phthalate metabolite levels and ran pulmonary function tests. Genetic polymorphisms of CAT (rs769218, rs769217), SOD2 (rs4880, rs2758331, rs5746136) and MPO (rs2071409, rs7208693) were determined. Mixed effect model was used to investigate association of phthalate levels with pulmonary function indices and to examine the effect of CAT, SOD2 and MPO polymorphisms on the association. Results: Inverse association was demonstrated between sum of mono-(2-ethyl-5-hydroxyhexyl) phthalate and mono-(2-ethyl-5-oxohexyl) phthalate (σDEHP) levels and FEV1/FVC (Β=-0.632, p=0.0275) or FEF25-75 (Β=-0.077, p=0.025) after adjusting for age, months after previous measurements, sex, body mass index, cotinine, mean temperature and dew point. The effect of σDEHP on lung function was significant only in subjects with certain genotypes, and having all significant genotypes in three genes showed significant difference in the phthalate-pulmonary function association (FEV1/FVC: Β=-2.169, p=0.0032; FEF25-75: Β=-0.155, p=0.0103), while other combinations showed less estimate size without any significance. Conclusions: Urinary phthalate metabolites levels are associated with decreasing pulmonary function in elderly Koreans, and effect modification of certain CAT, SOD2 and MPO polymorphisms on the association is suggested.",

keywords = "Elderly, Genetic polymorphisms, Oxidation, Phthalates, Pulmonary function",

author = "Park, {Hye Yin} and Kim, {Jin Hee} and Lim, {Youn Hee} and Sanghyuk Bae and Hong, {Yun Chul}",

note = "Funding Information: This study was supported by the Susceptible Population Research Program (2008–2010) of the Ministry of Environment and the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science and Technology (2011-0005907), Republic of Korea. ",

year = "2013",

month = apr,

doi = "10.1016/j.envres.2012.11.004",

language = "English",

volume = "122",

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T1 - Influence of genetic polymorphisms on the association between phthalate exposure and pulmonary function in the elderly

AU - Park, Hye Yin

AU - Kim, Jin Hee

AU - Lim, Youn Hee

AU - Bae, Sanghyuk

AU - Hong, Yun Chul

N1 - Funding Information: This study was supported by the Susceptible Population Research Program (2008–2010) of the Ministry of Environment and the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science and Technology (2011-0005907), Republic of Korea.

PY - 2013/4

Y1 - 2013/4

N2 - Background: Phthalates are prevalent environmental exposure chemicals with rising concern on various health effects, including pulmonary function. Meanwhile, elderly people are more susceptible to environmental exposure, and their decreasing lung function is an important health issue. Objectives: To investigate the association between urinary phthalate metabolite levels and indices for pulmonary function, and evaluate effect modification by genetic polymorphisms of oxidative-stress related genes, catalase (CAT), superoxide dismutase (SOD2), and myeloperoxidase (MPO) in elderly Koreans. Methods: We conducted a panel study on 418 individuals over 60 years old in Seoul, Korea, and repeatedly measured urinary phthalate metabolite levels and ran pulmonary function tests. Genetic polymorphisms of CAT (rs769218, rs769217), SOD2 (rs4880, rs2758331, rs5746136) and MPO (rs2071409, rs7208693) were determined. Mixed effect model was used to investigate association of phthalate levels with pulmonary function indices and to examine the effect of CAT, SOD2 and MPO polymorphisms on the association. Results: Inverse association was demonstrated between sum of mono-(2-ethyl-5-hydroxyhexyl) phthalate and mono-(2-ethyl-5-oxohexyl) phthalate (σDEHP) levels and FEV1/FVC (Β=-0.632, p=0.0275) or FEF25-75 (Β=-0.077, p=0.025) after adjusting for age, months after previous measurements, sex, body mass index, cotinine, mean temperature and dew point. The effect of σDEHP on lung function was significant only in subjects with certain genotypes, and having all significant genotypes in three genes showed significant difference in the phthalate-pulmonary function association (FEV1/FVC: Β=-2.169, p=0.0032; FEF25-75: Β=-0.155, p=0.0103), while other combinations showed less estimate size without any significance. Conclusions: Urinary phthalate metabolites levels are associated with decreasing pulmonary function in elderly Koreans, and effect modification of certain CAT, SOD2 and MPO polymorphisms on the association is suggested.

AB - Background: Phthalates are prevalent environmental exposure chemicals with rising concern on various health effects, including pulmonary function. Meanwhile, elderly people are more susceptible to environmental exposure, and their decreasing lung function is an important health issue. Objectives: To investigate the association between urinary phthalate metabolite levels and indices for pulmonary function, and evaluate effect modification by genetic polymorphisms of oxidative-stress related genes, catalase (CAT), superoxide dismutase (SOD2), and myeloperoxidase (MPO) in elderly Koreans. Methods: We conducted a panel study on 418 individuals over 60 years old in Seoul, Korea, and repeatedly measured urinary phthalate metabolite levels and ran pulmonary function tests. Genetic polymorphisms of CAT (rs769218, rs769217), SOD2 (rs4880, rs2758331, rs5746136) and MPO (rs2071409, rs7208693) were determined. Mixed effect model was used to investigate association of phthalate levels with pulmonary function indices and to examine the effect of CAT, SOD2 and MPO polymorphisms on the association. Results: Inverse association was demonstrated between sum of mono-(2-ethyl-5-hydroxyhexyl) phthalate and mono-(2-ethyl-5-oxohexyl) phthalate (σDEHP) levels and FEV1/FVC (Β=-0.632, p=0.0275) or FEF25-75 (Β=-0.077, p=0.025) after adjusting for age, months after previous measurements, sex, body mass index, cotinine, mean temperature and dew point. The effect of σDEHP on lung function was significant only in subjects with certain genotypes, and having all significant genotypes in three genes showed significant difference in the phthalate-pulmonary function association (FEV1/FVC: Β=-2.169, p=0.0032; FEF25-75: Β=-0.155, p=0.0103), while other combinations showed less estimate size without any significance. Conclusions: Urinary phthalate metabolites levels are associated with decreasing pulmonary function in elderly Koreans, and effect modification of certain CAT, SOD2 and MPO polymorphisms on the association is suggested.

KW - Elderly

KW - Genetic polymorphisms

KW - Oxidation

KW - Phthalates

KW - Pulmonary function

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JO - Environmental Research

JF - Environmental Research

ER -

Influence of genetic polymorphisms on the association between phthalate exposure and pulmonary function in the elderly

Abstract

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Keywords

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