Inter-individual body mass variations relate to fractionated functional brain hierarchies

Bo yong Park; Hyunjin Park; Filip Morys; Mansu Kim; Kyoungseob Byeon; Hyebin Lee; Se Hong Kim; Sofie L. Valk; Alain Dagher; Boris C. Bernhardt

doi:10.1038/s42003-021-02268-x

Inter-individual body mass variations relate to fractionated functional brain hierarchies

Bo yong Park, Hyunjin Park, Filip Morys, Mansu Kim, Kyoungseob Byeon, Hyebin Lee, Se Hong Kim, Sofie L. Valk, Alain Dagher, Boris C. Bernhardt

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Variations in body mass index (BMI) have been suggested to relate to atypical brain organization, yet connectome-level substrates of BMI and their neurobiological underpinnings remain unclear. Studying 325 healthy young adults, we examined associations between functional connectivity and inter-individual BMI variations. We utilized non-linear connectome manifold learning techniques to represent macroscale functional organization along continuous hierarchical axes that dissociate low level and higher order brain systems. We observed an increased differentiation between unimodal and heteromodal association networks in individuals with higher BMI, indicative of a disrupted modular architecture and hierarchy of the brain. Transcriptomic decoding and gene enrichment analyses identified genes previously implicated in genome-wide associations to BMI and specific cortical, striatal, and cerebellar cell types. These findings illustrate functional connectome substrates of BMI variations in healthy young adults and point to potential molecular associations.

Original language	English
Article number	735
Journal	Communications Biology
Volume	4
Issue number	1
DOIs	https://doi.org/10.1038/s42003-021-02268-x
State	Published - Dec 2021

Bibliographical note

Funding Information:
Data were provided, in part, by the Human Connectome Project, WU-Minn Consortium (Principal Investigators: David Van Essen and Kamil Ugurbil; 1U54MH091657) funded by the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research, and by the McDonnell Center for Systems Neuroscience at Washington University. Dr. Bo-yong Park was funded by INHA UNIVERSITY Research Grant (64617-01), the National Research Foundation of Korea (NRF-2020R1A6A3A03037088), Molson Neuro-Engineering fellowship by Montreal Neurological Institute and Hospital (MNI), and the Fonds de la Recherche du Québec – Santé (FRQ-S). Dr. Boris Bernhardt further acknowledges research support from the National Science and Engineering Research Council of Canada (NSERC Discovery-1304413), the Canadian Institutes of Health Research (CIHR FDN-154298, PJT-174995), SickKids Foundation (NI17-039), Azrieli Center for Autism Research (ACAR-TACC), BrainCanada, The Helmholtz Foundation/HIBALL, FRQ-S, and the Tier-2 Canada Research Chairs program.

Publisher Copyright:
© 2021, The Author(s).

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10.1038/s42003-021-02268-x

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title = "Inter-individual body mass variations relate to fractionated functional brain hierarchies",

abstract = "Variations in body mass index (BMI) have been suggested to relate to atypical brain organization, yet connectome-level substrates of BMI and their neurobiological underpinnings remain unclear. Studying 325 healthy young adults, we examined associations between functional connectivity and inter-individual BMI variations. We utilized non-linear connectome manifold learning techniques to represent macroscale functional organization along continuous hierarchical axes that dissociate low level and higher order brain systems. We observed an increased differentiation between unimodal and heteromodal association networks in individuals with higher BMI, indicative of a disrupted modular architecture and hierarchy of the brain. Transcriptomic decoding and gene enrichment analyses identified genes previously implicated in genome-wide associations to BMI and specific cortical, striatal, and cerebellar cell types. These findings illustrate functional connectome substrates of BMI variations in healthy young adults and point to potential molecular associations.",

author = "Park, {Bo yong} and Hyunjin Park and Filip Morys and Mansu Kim and Kyoungseob Byeon and Hyebin Lee and Kim, {Se Hong} and Valk, {Sofie L.} and Alain Dagher and Bernhardt, {Boris C.}",

note = "Funding Information: Data were provided, in part, by the Human Connectome Project, WU-Minn Consortium (Principal Investigators: David Van Essen and Kamil Ugurbil; 1U54MH091657) funded by the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research, and by the McDonnell Center for Systems Neuroscience at Washington University. Dr. Bo-yong Park was funded by INHA UNIVERSITY Research Grant (64617-01), the National Research Foundation of Korea (NRF-2020R1A6A3A03037088), Molson Neuro-Engineering fellowship by Montreal Neurological Institute and Hospital (MNI), and the Fonds de la Recherche du Qu{\'e}bec – Sant{\'e} (FRQ-S). Dr. Boris Bernhardt further acknowledges research support from the National Science and Engineering Research Council of Canada (NSERC Discovery-1304413), the Canadian Institutes of Health Research (CIHR FDN-154298, PJT-174995), SickKids Foundation (NI17-039), Azrieli Center for Autism Research (ACAR-TACC), BrainCanada, The Helmholtz Foundation/HIBALL, FRQ-S, and the Tier-2 Canada Research Chairs program. Publisher Copyright: {\textcopyright} 2021, The Author(s).",

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doi = "10.1038/s42003-021-02268-x",

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AU - Park, Hyunjin

AU - Morys, Filip

AU - Kim, Mansu

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AU - Lee, Hyebin

AU - Kim, Se Hong

AU - Valk, Sofie L.

AU - Dagher, Alain

AU - Bernhardt, Boris C.

N1 - Funding Information: Data were provided, in part, by the Human Connectome Project, WU-Minn Consortium (Principal Investigators: David Van Essen and Kamil Ugurbil; 1U54MH091657) funded by the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research, and by the McDonnell Center for Systems Neuroscience at Washington University. Dr. Bo-yong Park was funded by INHA UNIVERSITY Research Grant (64617-01), the National Research Foundation of Korea (NRF-2020R1A6A3A03037088), Molson Neuro-Engineering fellowship by Montreal Neurological Institute and Hospital (MNI), and the Fonds de la Recherche du Québec – Santé (FRQ-S). Dr. Boris Bernhardt further acknowledges research support from the National Science and Engineering Research Council of Canada (NSERC Discovery-1304413), the Canadian Institutes of Health Research (CIHR FDN-154298, PJT-174995), SickKids Foundation (NI17-039), Azrieli Center for Autism Research (ACAR-TACC), BrainCanada, The Helmholtz Foundation/HIBALL, FRQ-S, and the Tier-2 Canada Research Chairs program. Publisher Copyright: © 2021, The Author(s).

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Inter-individual body mass variations relate to fractionated functional brain hierarchies

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