Investigation of the bovine leukemia virus proviral DNA in human leukemias and lung cancers in Korea

Jehoon Lee; Yonggoo Kim; Suk Kang Chang; Hyun Cho Dae; Hwan Shin Dong; Na Yum Young; Ho Oh Jae; Hee Kim Sheen; Sil Hwang Myung; Joo Lim Chul; Hwa Yang Ki; Kyungja Han

doi:10.3346/jkms.2005.20.4.603

Investigation of the bovine leukemia virus proviral DNA in human leukemias and lung cancers in Korea

Jehoon Lee
, Yonggoo Kim
, Suk Kang Chang
, Hyun Cho Dae
, Hwan Shin Dong
, Na Yum Young
, Ho Oh Jae
, Hee Kim Sheen
, Sil Hwang Myung
, Joo Lim Chul
, Hwa Yang Ki
, Kyungja Han

Department of Laboratory Medicine

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The bovine leukemia virus (BLV) is the causative agent of enzootic bovine leucosis. This study investigated the presence of the BLV in leukemia (179 acute lymphoblastic leukemia, 292 acute myeloid leukemia and 46 chronic myelogenous leukemia cases) and 162 lung cancer patients (139 adenocarcinoma, 23 squamous cell carcinoma) to determine if the BLV is a causative organism of leukemia and lung cancer in Koreans. A BLV infection was confirmed in human cells by PCR using a BLV-8 primer combination. All 517 cases of human leukemia and 162 lung cancer were negative for a PCR of the BLV proviral DNA. In conclusion, although meat has been imported from BLV endemic areas, the BLV infection does not appear to be the cause of human leukemia or lung cancer in Koreans. These results can be used as a control for further studies on the BLV in Koreans.

Original language	English
Pages (from-to)	603-606
Number of pages	4
Journal	Journal of Korean Medical Science
Volume	20
Issue number	4
DOIs	https://doi.org/10.3346/jkms.2005.20.4.603
State	Published - Aug 2005

Keywords

Human Infection
Leukemia
Leukemia Virus, Bovine
Lung Neoplasms

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3346/jkms.2005.20.4.603

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@article{d54d3d0767a049f09668fbc1babd7b71,

title = "Investigation of the bovine leukemia virus proviral DNA in human leukemias and lung cancers in Korea",

abstract = "The bovine leukemia virus (BLV) is the causative agent of enzootic bovine leucosis. This study investigated the presence of the BLV in leukemia (179 acute lymphoblastic leukemia, 292 acute myeloid leukemia and 46 chronic myelogenous leukemia cases) and 162 lung cancer patients (139 adenocarcinoma, 23 squamous cell carcinoma) to determine if the BLV is a causative organism of leukemia and lung cancer in Koreans. A BLV infection was confirmed in human cells by PCR using a BLV-8 primer combination. All 517 cases of human leukemia and 162 lung cancer were negative for a PCR of the BLV proviral DNA. In conclusion, although meat has been imported from BLV endemic areas, the BLV infection does not appear to be the cause of human leukemia or lung cancer in Koreans. These results can be used as a control for further studies on the BLV in Koreans.",

keywords = "Human Infection, Leukemia, Leukemia Virus, Bovine, Lung Neoplasms",

author = "Jehoon Lee and Yonggoo Kim and Chang, \{Suk Kang\} and Dae, \{Hyun Cho\} and Dong, \{Hwan Shin\} and Young, \{Na Yum\} and Jae, \{Ho Oh\} and Sheen, \{Hee Kim\} and Myung, \{Sil Hwang\} and Chul, \{Joo Lim\} and Ki, \{Hwa Yang\} and Kyungja Han",

year = "2005",

month = aug,

doi = "10.3346/jkms.2005.20.4.603",

language = "English",

volume = "20",

pages = "603--606",

journal = "Journal of Korean Medical Science",

issn = "1011-8934",

publisher = "Korean Academy of Medical Science",

number = "4",

}

TY - JOUR

T1 - Investigation of the bovine leukemia virus proviral DNA in human leukemias and lung cancers in Korea

AU - Lee, Jehoon

AU - Kim, Yonggoo

AU - Chang, Suk Kang

AU - Dae, Hyun Cho

AU - Dong, Hwan Shin

AU - Young, Na Yum

AU - Jae, Ho Oh

AU - Sheen, Hee Kim

AU - Myung, Sil Hwang

AU - Chul, Joo Lim

AU - Ki, Hwa Yang

AU - Han, Kyungja

PY - 2005/8

Y1 - 2005/8

N2 - The bovine leukemia virus (BLV) is the causative agent of enzootic bovine leucosis. This study investigated the presence of the BLV in leukemia (179 acute lymphoblastic leukemia, 292 acute myeloid leukemia and 46 chronic myelogenous leukemia cases) and 162 lung cancer patients (139 adenocarcinoma, 23 squamous cell carcinoma) to determine if the BLV is a causative organism of leukemia and lung cancer in Koreans. A BLV infection was confirmed in human cells by PCR using a BLV-8 primer combination. All 517 cases of human leukemia and 162 lung cancer were negative for a PCR of the BLV proviral DNA. In conclusion, although meat has been imported from BLV endemic areas, the BLV infection does not appear to be the cause of human leukemia or lung cancer in Koreans. These results can be used as a control for further studies on the BLV in Koreans.

AB - The bovine leukemia virus (BLV) is the causative agent of enzootic bovine leucosis. This study investigated the presence of the BLV in leukemia (179 acute lymphoblastic leukemia, 292 acute myeloid leukemia and 46 chronic myelogenous leukemia cases) and 162 lung cancer patients (139 adenocarcinoma, 23 squamous cell carcinoma) to determine if the BLV is a causative organism of leukemia and lung cancer in Koreans. A BLV infection was confirmed in human cells by PCR using a BLV-8 primer combination. All 517 cases of human leukemia and 162 lung cancer were negative for a PCR of the BLV proviral DNA. In conclusion, although meat has been imported from BLV endemic areas, the BLV infection does not appear to be the cause of human leukemia or lung cancer in Koreans. These results can be used as a control for further studies on the BLV in Koreans.

KW - Human Infection

KW - Leukemia

KW - Leukemia Virus, Bovine

KW - Lung Neoplasms

UR - https://www.scopus.com/pages/publications/24644500412

U2 - 10.3346/jkms.2005.20.4.603

DO - 10.3346/jkms.2005.20.4.603

M3 - Article

AN - SCOPUS:24644500412

SN - 1011-8934

VL - 20

SP - 603

EP - 606

JO - Journal of Korean Medical Science

JF - Journal of Korean Medical Science

IS - 4

ER -

Investigation of the bovine leukemia virus proviral DNA in human leukemias and lung cancers in Korea

Abstract

Keywords

UN SDGs

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