Abstract
In this study, we investigated how Staufenl influences the HIV-1 production. The overexpression of Staufen1 increased virus production without any negative affect on the viral infectivity. This increase was not caused by transcriptional activation; but by influencing post-transcriptional steps. Using multiple Gag protein derivatives, we confirmed that the zinc-finger domains of the HIV-1 nucleocapsid (NC) are important for its interaction with Staufen1. We also found that Staufen1 colocalized in stress granules with the mature form of the HIV-1 NC protein.
| Original language | English |
|---|---|
| Pages (from-to) | 551-556 |
| Number of pages | 6 |
| Journal | BMB Reports |
| Volume | 54 |
| Issue number | 11 |
| DOIs | |
| State | Published - 2021 |
Bibliographical note
Publisher Copyright:© 2021. The Korean Society for Biochemistry and Molecular Biology.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- HIV-1
- RNA-binding proteins
- Staufen1
- Virus replication
- Virus-host interaction
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