Iron Oxide-Coated Dextran Nanoparticles with Efficient Renal Clearance for Musculoskeletal Magnetic Resonance Imaging

Ji Wook Kim; Jiyong Cheong; Hayeon Cheong; Jun Geol Yoon; Joon Yong Jung; Jae Hyun Lee; Tae Hyun Shin

doi:10.1021/acsanm.1c03470

Iron Oxide-Coated Dextran Nanoparticles with Efficient Renal Clearance for Musculoskeletal Magnetic Resonance Imaging

Ji Wook Kim, Jiyong Cheong, Hayeon Cheong, Jun Geol Yoon, Joon Yong Jung, Jae Hyun Lee, Tae Hyun Shin

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We report that inverted iron oxide nanoparticles (i-IONPs) have great potential for musculoskeletal imaging, which is one of the fastest-growing fields in MRI. Upon intra-articular injection, i-IONPs provide positive T1 values and decent soft tissue contrast effects, allowing a clear visualization of complex anatomical details of the joint. i-IONPs show substantially stronger and longer-lasting T1 contrast effects than clinical gadolinium-based contrast agents. In addition, i-IONPs are completely eliminated from the joint cavity without accumulation or harmful effects and are excreted from body through a renal clearance route.

Original language	English
Pages (from-to)	12943-12948
Number of pages	6
Journal	ACS Applied Nano Materials
Volume	4
Issue number	12
DOIs	https://doi.org/10.1021/acsanm.1c03470
State	Published - 24 Dec 2021

Bibliographical note

Funding Information:
This work has been supported by the National Research Foundation of Korea (NRF) grant (No. 2019R1C1C1010887) funded by the Ministry of Science and ICT (MSIT), Tech Incubator Program for Startup Korea (TIPS, No. S2689777) funded by the Ministry of SMEs and Startups (MSS), and Government-funded Technology Commercialization Program through the Korea Institute for Advancement of Technology (KIAT) funded by the Ministry of Trade, Industry and Energy (MOTIE) (Grant No. P0018235).

Publisher Copyright:
© 2021 American Chemical Society.

Keywords

contrast agent
dextran nanoparticle
iron oxide
MRI
musculoskeletal imaging
renal clearance

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title = "Iron Oxide-Coated Dextran Nanoparticles with Efficient Renal Clearance for Musculoskeletal Magnetic Resonance Imaging",

abstract = "We report that inverted iron oxide nanoparticles (i-IONPs) have great potential for musculoskeletal imaging, which is one of the fastest-growing fields in MRI. Upon intra-articular injection, i-IONPs provide positive T1 values and decent soft tissue contrast effects, allowing a clear visualization of complex anatomical details of the joint. i-IONPs show substantially stronger and longer-lasting T1 contrast effects than clinical gadolinium-based contrast agents. In addition, i-IONPs are completely eliminated from the joint cavity without accumulation or harmful effects and are excreted from body through a renal clearance route.",

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note = "Funding Information: This work has been supported by the National Research Foundation of Korea (NRF) grant (No. 2019R1C1C1010887) funded by the Ministry of Science and ICT (MSIT), Tech Incubator Program for Startup Korea (TIPS, No. S2689777) funded by the Ministry of SMEs and Startups (MSS), and Government-funded Technology Commercialization Program through the Korea Institute for Advancement of Technology (KIAT) funded by the Ministry of Trade, Industry and Energy (MOTIE) (Grant No. P0018235). Publisher Copyright: {\textcopyright} 2021 American Chemical Society.",

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T1 - Iron Oxide-Coated Dextran Nanoparticles with Efficient Renal Clearance for Musculoskeletal Magnetic Resonance Imaging

AU - Kim, Ji Wook

AU - Cheong, Jiyong

AU - Cheong, Hayeon

AU - Yoon, Jun Geol

AU - Jung, Joon Yong

AU - Lee, Jae Hyun

AU - Shin, Tae Hyun

N1 - Funding Information: This work has been supported by the National Research Foundation of Korea (NRF) grant (No. 2019R1C1C1010887) funded by the Ministry of Science and ICT (MSIT), Tech Incubator Program for Startup Korea (TIPS, No. S2689777) funded by the Ministry of SMEs and Startups (MSS), and Government-funded Technology Commercialization Program through the Korea Institute for Advancement of Technology (KIAT) funded by the Ministry of Trade, Industry and Energy (MOTIE) (Grant No. P0018235). Publisher Copyright: © 2021 American Chemical Society.

PY - 2021/12/24

Y1 - 2021/12/24

N2 - We report that inverted iron oxide nanoparticles (i-IONPs) have great potential for musculoskeletal imaging, which is one of the fastest-growing fields in MRI. Upon intra-articular injection, i-IONPs provide positive T1 values and decent soft tissue contrast effects, allowing a clear visualization of complex anatomical details of the joint. i-IONPs show substantially stronger and longer-lasting T1 contrast effects than clinical gadolinium-based contrast agents. In addition, i-IONPs are completely eliminated from the joint cavity without accumulation or harmful effects and are excreted from body through a renal clearance route.

AB - We report that inverted iron oxide nanoparticles (i-IONPs) have great potential for musculoskeletal imaging, which is one of the fastest-growing fields in MRI. Upon intra-articular injection, i-IONPs provide positive T1 values and decent soft tissue contrast effects, allowing a clear visualization of complex anatomical details of the joint. i-IONPs show substantially stronger and longer-lasting T1 contrast effects than clinical gadolinium-based contrast agents. In addition, i-IONPs are completely eliminated from the joint cavity without accumulation or harmful effects and are excreted from body through a renal clearance route.

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KW - musculoskeletal imaging

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ER -

Iron Oxide-Coated Dextran Nanoparticles with Efficient Renal Clearance for Musculoskeletal Magnetic Resonance Imaging

Abstract

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