Iron Oxide-Coated Dextran Nanoparticles with Efficient Renal Clearance for Musculoskeletal Magnetic Resonance Imaging

Ji Wook Kim; Jiyong Cheong; Hayeon Cheong; Jun Geol Yoon; Joon Yong Jung; Jae Hyun Lee; Tae Hyun Shin

doi:10.1021/acsanm.1c03470

Iron Oxide-Coated Dextran Nanoparticles with Efficient Renal Clearance for Musculoskeletal Magnetic Resonance Imaging

Ji Wook Kim
, Jiyong Cheong
, Hayeon Cheong
, Jun Geol Yoon
, Joon Yong Jung
, Jae Hyun Lee
, Tae Hyun Shin

Inventera Pharmaceuticals Inc.
Yonsei University
Kyung Hee University
Korea Basic Science Institute

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

We report that inverted iron oxide nanoparticles (i-IONPs) have great potential for musculoskeletal imaging, which is one of the fastest-growing fields in MRI. Upon intra-articular injection, i-IONPs provide positive T1 values and decent soft tissue contrast effects, allowing a clear visualization of complex anatomical details of the joint. i-IONPs show substantially stronger and longer-lasting T1 contrast effects than clinical gadolinium-based contrast agents. In addition, i-IONPs are completely eliminated from the joint cavity without accumulation or harmful effects and are excreted from body through a renal clearance route.

Original language	English
Pages (from-to)	12943-12948
Number of pages	6
Journal	ACS Applied Nano Materials
Volume	4
Issue number	12
DOIs	https://doi.org/10.1021/acsanm.1c03470
State	Published - 24 Dec 2021

Bibliographical note

Publisher Copyright:
© 2021 American Chemical Society.

Keywords

MRI
contrast agent
dextran nanoparticle
iron oxide
musculoskeletal imaging
renal clearance

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10.1021/acsanm.1c03470

Cite this

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title = "Iron Oxide-Coated Dextran Nanoparticles with Efficient Renal Clearance for Musculoskeletal Magnetic Resonance Imaging",

abstract = "We report that inverted iron oxide nanoparticles (i-IONPs) have great potential for musculoskeletal imaging, which is one of the fastest-growing fields in MRI. Upon intra-articular injection, i-IONPs provide positive T1 values and decent soft tissue contrast effects, allowing a clear visualization of complex anatomical details of the joint. i-IONPs show substantially stronger and longer-lasting T1 contrast effects than clinical gadolinium-based contrast agents. In addition, i-IONPs are completely eliminated from the joint cavity without accumulation or harmful effects and are excreted from body through a renal clearance route.",

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T1 - Iron Oxide-Coated Dextran Nanoparticles with Efficient Renal Clearance for Musculoskeletal Magnetic Resonance Imaging

AU - Kim, Ji Wook

AU - Cheong, Jiyong

AU - Cheong, Hayeon

AU - Yoon, Jun Geol

AU - Jung, Joon Yong

AU - Lee, Jae Hyun

AU - Shin, Tae Hyun

PY - 2021/12/24

Y1 - 2021/12/24

N2 - We report that inverted iron oxide nanoparticles (i-IONPs) have great potential for musculoskeletal imaging, which is one of the fastest-growing fields in MRI. Upon intra-articular injection, i-IONPs provide positive T1 values and decent soft tissue contrast effects, allowing a clear visualization of complex anatomical details of the joint. i-IONPs show substantially stronger and longer-lasting T1 contrast effects than clinical gadolinium-based contrast agents. In addition, i-IONPs are completely eliminated from the joint cavity without accumulation or harmful effects and are excreted from body through a renal clearance route.

AB - We report that inverted iron oxide nanoparticles (i-IONPs) have great potential for musculoskeletal imaging, which is one of the fastest-growing fields in MRI. Upon intra-articular injection, i-IONPs provide positive T1 values and decent soft tissue contrast effects, allowing a clear visualization of complex anatomical details of the joint. i-IONPs show substantially stronger and longer-lasting T1 contrast effects than clinical gadolinium-based contrast agents. In addition, i-IONPs are completely eliminated from the joint cavity without accumulation or harmful effects and are excreted from body through a renal clearance route.

KW - MRI

KW - contrast agent

KW - dextran nanoparticle

KW - iron oxide

KW - musculoskeletal imaging

KW - renal clearance

UR - https://www.scopus.com/pages/publications/85120855092

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M3 - Article

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SN - 2574-0970

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JO - ACS Applied Nano Materials

JF - ACS Applied Nano Materials

IS - 12

ER -

Iron Oxide-Coated Dextran Nanoparticles with Efficient Renal Clearance for Musculoskeletal Magnetic Resonance Imaging

Abstract

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Keywords

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