Keratinocytes cut corners on the cell cycle for the sake of skin barrier integrity

Renzhi Hou; Jung Eun Kim; Maksim V. Plikus

doi:10.1016/j.devcel.2022.06.001

Keratinocytes cut corners on the cell cycle for the sake of skin barrier integrity

Renzhi Hou, Jung Eun Kim, Maksim V. Plikus

Department of Dermatology

University of California at Irvine

Research output: Contribution to journal › Comment/debate

2 Scopus citations

Abstract

Epidermis can grow its surface by activating mitotic division in basal stem cells. In a recent issue of Nature, Chan et al. (2022) show that under high demand for new skin, differentiated epidermal cells in zebrafish divide without DNA synthesis, forming cells in the new surface with reduced and abnormal genomes.

Original language	English
Pages (from-to)	1437-1438
Number of pages	2
Journal	Developmental Cell
Volume	57
Issue number	12
DOIs	https://doi.org/10.1016/j.devcel.2022.06.001
State	Published - 20 Jun 2022

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© 2022 Elsevier Inc.

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10.1016/j.devcel.2022.06.001

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title = "Keratinocytes cut corners on the cell cycle for the sake of skin barrier integrity",

abstract = "Epidermis can grow its surface by activating mitotic division in basal stem cells. In a recent issue of Nature, Chan et al. (2022) show that under high demand for new skin, differentiated epidermal cells in zebrafish divide without DNA synthesis, forming cells in the new surface with reduced and abnormal genomes.",

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AU - Hou, Renzhi

AU - Kim, Jung Eun

AU - Plikus, Maksim V.

PY - 2022/6/20

Y1 - 2022/6/20

N2 - Epidermis can grow its surface by activating mitotic division in basal stem cells. In a recent issue of Nature, Chan et al. (2022) show that under high demand for new skin, differentiated epidermal cells in zebrafish divide without DNA synthesis, forming cells in the new surface with reduced and abnormal genomes.

AB - Epidermis can grow its surface by activating mitotic division in basal stem cells. In a recent issue of Nature, Chan et al. (2022) show that under high demand for new skin, differentiated epidermal cells in zebrafish divide without DNA synthesis, forming cells in the new surface with reduced and abnormal genomes.

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U2 - 10.1016/j.devcel.2022.06.001

DO - 10.1016/j.devcel.2022.06.001

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SN - 1534-5807

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SP - 1437

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JO - Developmental Cell

JF - Developmental Cell

IS - 12

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Keratinocytes cut corners on the cell cycle for the sake of skin barrier integrity

Abstract

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