Linear and non-linear EEG analysis of adolescents with attention-deficit/hyperactivity disorder during a cognitive task

Hansem Sohn; Inhye Kim; Wonhye Lee; Bradley S. Peterson; Hyunju Hong; Jeong Ho Chae; Sayong Hong; Jaeseung Jeong

doi:10.1016/j.clinph.2010.04.007

Linear and non-linear EEG analysis of adolescents with attention-deficit/hyperactivity disorder during a cognitive task

Hansem Sohn
, Inhye Kim
, Wonhye Lee
, Bradley S. Peterson
, Hyunju Hong
, Jeong Ho Chae
, Sayong Hong
, Jaeseung Jeong

Department of Psychiatry

Korea Advanced Institute of Science and Technology
Kongju National University
Columbia University
Hallym University

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

Abstract

Objective: We aimed to investigate whether electroencephalograph (EEG) dynamics differ in adolescents with attention-deficit/hyperactivity disorder (ADHD) compared with healthy subjects during the performance of a cognitive task. Methods: We recorded EEGs from 19 scalp electrodes in 11 adolescent boys with ADHD and 12 age-matched healthy boys while the subjects were at rest and during a continuous performance test (CPT). The approximate entropy (ApEn), a non-linear information-theoretic measure, was calculated to quantify the complexity of the EEGs. Results: The mean ApEn of the ADHD patients was significantly lower than the healthy subjects over the right frontal regions (Fp2 and F8) during the performance of the cognitive task, but not at rest. The spectral analysis showed significant differences between the two groups in the P3 and T4 regions at rest and the Fp2 and F8 regions during task performance. Conclusions: The differences in EEG complexity between the two groups suggest that cortical information processing is altered in ADHD adolescents, and thus their levels of cortical activation may be insufficient to meet the cognitive requirements of attention-demanding tasks. Significance: This study suggests that a non-linear measure such as ApEn is useful for investigating neural dysfunctions in adolescents with ADHD.

Original language	English
Pages (from-to)	1863-1870
Number of pages	8
Journal	Clinical Neurophysiology
Volume	121
Issue number	11
DOIs	https://doi.org/10.1016/j.clinph.2010.04.007
State	Published - Nov 2010

Bibliographical note

Funding Information:
The authors thank EEG technician Hyejin Kim at the Catholic University of Korea for her technical assistance. This work was supported by the CHUNG Moon Soul Research Center for BioInformation and BioElectronics (CMSC) in KAIST, a Korean Science and Engineering Foundation (KOSEF) grant funded by the Korean government (MOST) (Nos. R01-2003-000-10432-0 and M10644000028-06N4400-02810), and grant No.NNA0130 from the Korea Advanced Institute of Science and Technology.

Keywords

Approximate entropy
Attention-deficit/hyperactivity disorder
Complexity
Continuous performance test
EEG

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10.1016/j.clinph.2010.04.007

Cite this

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title = "Linear and non-linear EEG analysis of adolescents with attention-deficit/hyperactivity disorder during a cognitive task",

abstract = "Objective: We aimed to investigate whether electroencephalograph (EEG) dynamics differ in adolescents with attention-deficit/hyperactivity disorder (ADHD) compared with healthy subjects during the performance of a cognitive task. Methods: We recorded EEGs from 19 scalp electrodes in 11 adolescent boys with ADHD and 12 age-matched healthy boys while the subjects were at rest and during a continuous performance test (CPT). The approximate entropy (ApEn), a non-linear information-theoretic measure, was calculated to quantify the complexity of the EEGs. Results: The mean ApEn of the ADHD patients was significantly lower than the healthy subjects over the right frontal regions (Fp2 and F8) during the performance of the cognitive task, but not at rest. The spectral analysis showed significant differences between the two groups in the P3 and T4 regions at rest and the Fp2 and F8 regions during task performance. Conclusions: The differences in EEG complexity between the two groups suggest that cortical information processing is altered in ADHD adolescents, and thus their levels of cortical activation may be insufficient to meet the cognitive requirements of attention-demanding tasks. Significance: This study suggests that a non-linear measure such as ApEn is useful for investigating neural dysfunctions in adolescents with ADHD.",

keywords = "Approximate entropy, Attention-deficit/hyperactivity disorder, Complexity, Continuous performance test, EEG",

author = "Hansem Sohn and Inhye Kim and Wonhye Lee and Peterson, \{Bradley S.\} and Hyunju Hong and Chae, \{Jeong Ho\} and Sayong Hong and Jaeseung Jeong",

note = "Funding Information: The authors thank EEG technician Hyejin Kim at the Catholic University of Korea for her technical assistance. This work was supported by the CHUNG Moon Soul Research Center for BioInformation and BioElectronics (CMSC) in KAIST, a Korean Science and Engineering Foundation (KOSEF) grant funded by the Korean government (MOST) (Nos. R01-2003-000-10432-0 and M10644000028-06N4400-02810), and grant No.NNA0130 from the Korea Advanced Institute of Science and Technology. ",

year = "2010",

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doi = "10.1016/j.clinph.2010.04.007",

language = "English",

volume = "121",

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T1 - Linear and non-linear EEG analysis of adolescents with attention-deficit/hyperactivity disorder during a cognitive task

AU - Sohn, Hansem

AU - Kim, Inhye

AU - Lee, Wonhye

AU - Peterson, Bradley S.

AU - Hong, Hyunju

AU - Chae, Jeong Ho

AU - Hong, Sayong

AU - Jeong, Jaeseung

N1 - Funding Information: The authors thank EEG technician Hyejin Kim at the Catholic University of Korea for her technical assistance. This work was supported by the CHUNG Moon Soul Research Center for BioInformation and BioElectronics (CMSC) in KAIST, a Korean Science and Engineering Foundation (KOSEF) grant funded by the Korean government (MOST) (Nos. R01-2003-000-10432-0 and M10644000028-06N4400-02810), and grant No.NNA0130 from the Korea Advanced Institute of Science and Technology.

PY - 2010/11

Y1 - 2010/11

N2 - Objective: We aimed to investigate whether electroencephalograph (EEG) dynamics differ in adolescents with attention-deficit/hyperactivity disorder (ADHD) compared with healthy subjects during the performance of a cognitive task. Methods: We recorded EEGs from 19 scalp electrodes in 11 adolescent boys with ADHD and 12 age-matched healthy boys while the subjects were at rest and during a continuous performance test (CPT). The approximate entropy (ApEn), a non-linear information-theoretic measure, was calculated to quantify the complexity of the EEGs. Results: The mean ApEn of the ADHD patients was significantly lower than the healthy subjects over the right frontal regions (Fp2 and F8) during the performance of the cognitive task, but not at rest. The spectral analysis showed significant differences between the two groups in the P3 and T4 regions at rest and the Fp2 and F8 regions during task performance. Conclusions: The differences in EEG complexity between the two groups suggest that cortical information processing is altered in ADHD adolescents, and thus their levels of cortical activation may be insufficient to meet the cognitive requirements of attention-demanding tasks. Significance: This study suggests that a non-linear measure such as ApEn is useful for investigating neural dysfunctions in adolescents with ADHD.

AB - Objective: We aimed to investigate whether electroencephalograph (EEG) dynamics differ in adolescents with attention-deficit/hyperactivity disorder (ADHD) compared with healthy subjects during the performance of a cognitive task. Methods: We recorded EEGs from 19 scalp electrodes in 11 adolescent boys with ADHD and 12 age-matched healthy boys while the subjects were at rest and during a continuous performance test (CPT). The approximate entropy (ApEn), a non-linear information-theoretic measure, was calculated to quantify the complexity of the EEGs. Results: The mean ApEn of the ADHD patients was significantly lower than the healthy subjects over the right frontal regions (Fp2 and F8) during the performance of the cognitive task, but not at rest. The spectral analysis showed significant differences between the two groups in the P3 and T4 regions at rest and the Fp2 and F8 regions during task performance. Conclusions: The differences in EEG complexity between the two groups suggest that cortical information processing is altered in ADHD adolescents, and thus their levels of cortical activation may be insufficient to meet the cognitive requirements of attention-demanding tasks. Significance: This study suggests that a non-linear measure such as ApEn is useful for investigating neural dysfunctions in adolescents with ADHD.

KW - Approximate entropy

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KW - Complexity

KW - Continuous performance test

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ER -

Linear and non-linear EEG analysis of adolescents with attention-deficit/hyperactivity disorder during a cognitive task

Abstract

Bibliographical note

Keywords

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