Liver transplantation for combined hepatocellular carcinoma and cholangiocarcinoma in Korea

Jong Man Kim, Dong Jin Joo, Shin Hwang, Nam Joon Yi, Je Ho Ryu, Yang Won Na, Dong Sik Kim, Doo Jin Kim, Young Kyoung Yoo, Hee Chul Yu, Myoung Soo Kim

Research output: Contribution to journalComment/debate

Abstract

Introduction: There is still no consensus about the actual role of liver transplantation (LT) in the therapeutic algorithm of combined hepatocellular-cholangiocarcinoma (cHCC-CC) because of low incidence and few clinical information. Methods: We retrospectively identified 111 patients at nine centers from 2001 to 2019 in Korea. Results: Of the 111 patients, 85.6% (n = 95) was male and the median age was 54 years (range, 31–66 years). HBV is 82% (n = 91) and HCC is 96% (86.3%) preoperatively. Seventy-four patients (66.7%) received locoregional therapy (LRT) before LT. Median tumor size was 2.5 cm (range, 0.5–7.2 cm) and the ratio of beyond Milan criteria was 40.5% (n = 45). The 1-year, 3-year, and 5-year disease-free survival rates and tumor-related patient survival rates were 77.6%, 56.3%, and 51.1% and 84.4%, 63.8%, and 56.7%, respectively. The extrahepatic site was 75.5% as an initial tumor recurrence site in recurrent tumor patients. Numbers of LRT before LT >3 and tumor size > 3 cm were closely associated tumor recurrence and early tumor recurrence within 1 year after LT. Tumor size > 3 cm was only predisposing factor for tumor-related death. Conclusions: It is difficult to diagnose cHCC-CC before LT, but a good prognosis can be expected if the tumor size is less than 3 cm in pathology.

Original languageEnglish
Pages (from-to)S57
JournalAnnals of Hepato-Biliary-Pancreatic Surgery
Volume25
DOIs
StatePublished - Jun 2021

Bibliographical note

Publisher Copyright:
© The Korean Association of Hepato-Biliary-Pancreatic Surgery.

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