Luciferase-Rose Bengal conjugates for singlet oxygen generation by bioluminescence resonance energy transfer

Seonghoon Kim; Hyeongchan Jo; Mijeong Jeon; Myung Gyu Choi; Sei Kwang Hahn; Seok Hyun Yun

doi:10.1039/c7cc00041c

Luciferase-Rose Bengal conjugates for singlet oxygen generation by bioluminescence resonance energy transfer

Seonghoon Kim
, Hyeongchan Jo
, Mijeong Jeon
, Myung Gyu Choi
, Sei Kwang Hahn
, Seok Hyun Yun

Division of Gastroenterology

Massachusetts General Hospital
Korea Advanced Institute of Science and Technology
Pohang University of Science and Technology

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Conjugates of Rose Bengal and Renilla luciferase generated singlet oxygen upon binding with coelenterazine via bioluminescence resonance energy transfer (BRET). Since the applications of conventional PDT have been limited to superficial lesions due to the limited light penetration in tissue, BRET activated PDT which does not require external light illumination may overcome the limitations of conventional PDT.

Original language	English
Pages (from-to)	4569-4572
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	33
DOIs	https://doi.org/10.1039/c7cc00041c
State	Published - 2017

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Publisher Copyright:
© The Royal Society of Chemistry.

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10.1039/c7cc00041c

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title = "Luciferase-Rose Bengal conjugates for singlet oxygen generation by bioluminescence resonance energy transfer",

abstract = "Conjugates of Rose Bengal and Renilla luciferase generated singlet oxygen upon binding with coelenterazine via bioluminescence resonance energy transfer (BRET). Since the applications of conventional PDT have been limited to superficial lesions due to the limited light penetration in tissue, BRET activated PDT which does not require external light illumination may overcome the limitations of conventional PDT.",

author = "Seonghoon Kim and Hyeongchan Jo and Mijeong Jeon and Choi, \{Myung Gyu\} and Hahn, \{Sei Kwang\} and Yun, \{Seok Hyun\}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2017",

doi = "10.1039/c7cc00041c",

language = "English",

volume = "53",

pages = "4569--4572",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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T1 - Luciferase-Rose Bengal conjugates for singlet oxygen generation by bioluminescence resonance energy transfer

AU - Kim, Seonghoon

AU - Jo, Hyeongchan

AU - Jeon, Mijeong

AU - Choi, Myung Gyu

AU - Hahn, Sei Kwang

AU - Yun, Seok Hyun

PY - 2017

Y1 - 2017

N2 - Conjugates of Rose Bengal and Renilla luciferase generated singlet oxygen upon binding with coelenterazine via bioluminescence resonance energy transfer (BRET). Since the applications of conventional PDT have been limited to superficial lesions due to the limited light penetration in tissue, BRET activated PDT which does not require external light illumination may overcome the limitations of conventional PDT.

AB - Conjugates of Rose Bengal and Renilla luciferase generated singlet oxygen upon binding with coelenterazine via bioluminescence resonance energy transfer (BRET). Since the applications of conventional PDT have been limited to superficial lesions due to the limited light penetration in tissue, BRET activated PDT which does not require external light illumination may overcome the limitations of conventional PDT.

UR - https://www.scopus.com/pages/publications/85018510748

U2 - 10.1039/c7cc00041c

DO - 10.1039/c7cc00041c

M3 - Article

C2 - 28387393

AN - SCOPUS:85018510748

SN - 1359-7345

VL - 53

SP - 4569

EP - 4572

JO - Chemical Communications

JF - Chemical Communications

IS - 33

ER -

Luciferase-Rose Bengal conjugates for singlet oxygen generation by bioluminescence resonance energy transfer

Abstract

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