Magnetic liposomal particles for magnetic imaging, sensing, and the pH-sensitive delivery of therapeutics

Yong Su Kwon; Su Jin Jang; Young Il Yoon; Hee Sang Cho; Hak Jong Lee; Young Seok Cho; Hyun Soo Shin; Tae Jong Yoon

doi:10.1002/ppsc.201600041

Magnetic liposomal particles for magnetic imaging, sensing, and the pH-sensitive delivery of therapeutics

Yong Su Kwon
, Su Jin Jang
, Young Il Yoon
, Hee Sang Cho
, Hak Jong Lee
, Young Seok Cho
, Hyun Soo Shin
, Tae Jong Yoon

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

To maintain magnetic properties, physical properties, and bio-applicability, a liposomal structure is introduced to the magnetic MNP@mSiO₂ (MagLipo). EGFR-antibody-conjugated MagLipo is successfully applied for T₂-w imaging and magnetic sensing after specific targeting to BxPC3 pancreatic cancer. Furthermore, the MagLipo carrying a therapeutic drug and gene shows a high therapeutic effect with drug release in a pH-sensitive manner in vitro.

Original language	English
Pages (from-to)	242-247
Number of pages	6
Journal	Particle and Particle Systems Characterization
Volume	33
Issue number	5
DOIs	https://doi.org/10.1002/ppsc.201600041
State	Published - 1 May 2016

Bibliographical note

Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

cancer targeting
drug and gene delivery
magnetic iron oxide nanoparticle
magnetic sensing
mesoporous silica shell

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ppsc.201600041

Cite this

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title = "Magnetic liposomal particles for magnetic imaging, sensing, and the pH-sensitive delivery of therapeutics",

abstract = "To maintain magnetic properties, physical properties, and bio-applicability, a liposomal structure is introduced to the magnetic MNP@mSiO2 (MagLipo). EGFR-antibody-conjugated MagLipo is successfully applied for T2-w imaging and magnetic sensing after specific targeting to BxPC3 pancreatic cancer. Furthermore, the MagLipo carrying a therapeutic drug and gene shows a high therapeutic effect with drug release in a pH-sensitive manner in vitro.",

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doi = "10.1002/ppsc.201600041",

language = "English",

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T1 - Magnetic liposomal particles for magnetic imaging, sensing, and the pH-sensitive delivery of therapeutics

AU - Kwon, Yong Su

AU - Jang, Su Jin

AU - Yoon, Young Il

AU - Cho, Hee Sang

AU - Lee, Hak Jong

AU - Cho, Young Seok

AU - Shin, Hyun Soo

AU - Yoon, Tae Jong

PY - 2016/5/1

Y1 - 2016/5/1

N2 - To maintain magnetic properties, physical properties, and bio-applicability, a liposomal structure is introduced to the magnetic MNP@mSiO2 (MagLipo). EGFR-antibody-conjugated MagLipo is successfully applied for T2-w imaging and magnetic sensing after specific targeting to BxPC3 pancreatic cancer. Furthermore, the MagLipo carrying a therapeutic drug and gene shows a high therapeutic effect with drug release in a pH-sensitive manner in vitro.

AB - To maintain magnetic properties, physical properties, and bio-applicability, a liposomal structure is introduced to the magnetic MNP@mSiO2 (MagLipo). EGFR-antibody-conjugated MagLipo is successfully applied for T2-w imaging and magnetic sensing after specific targeting to BxPC3 pancreatic cancer. Furthermore, the MagLipo carrying a therapeutic drug and gene shows a high therapeutic effect with drug release in a pH-sensitive manner in vitro.

KW - cancer targeting

KW - drug and gene delivery

KW - magnetic iron oxide nanoparticle

KW - magnetic sensing

KW - mesoporous silica shell

UR - https://www.scopus.com/pages/publications/84963747565

U2 - 10.1002/ppsc.201600041

DO - 10.1002/ppsc.201600041

M3 - Article

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SN - 0934-0866

VL - 33

SP - 242

EP - 247

JO - Particle and Particle Systems Characterization

JF - Particle and Particle Systems Characterization

IS - 5

ER -

Magnetic liposomal particles for magnetic imaging, sensing, and the pH-sensitive delivery of therapeutics

Abstract

Bibliographical note

Keywords

UN SDGs

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