Manganese superoxide dismutase (MnSOD: Ala-9Val) gene polymorphism may not be associated with schizophrenia and tardive dyskinesia

Chi Un Pae; Tae Suk Kim; Ashwin A. Patkar; Jung Jin Kim; Chang Uk Lee; Soo Jung Lee; Tae Youn Jun; Chul Lee; In Ho Paik

doi:10.1016/j.psychres.2006.04.011

Manganese superoxide dismutase (MnSOD: Ala-9Val) gene polymorphism may not be associated with schizophrenia and tardive dyskinesia

Chi Un Pae
, Tae Suk Kim
, Ashwin A. Patkar
, Jung Jin Kim
, Chang Uk Lee
, Soo Jung Lee
, Tae Youn Jun
, Chul Lee
, In Ho Paik

Department of Psychiatry

Catholic Univ. of Korea Coll. Med.
Duke University

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

There has been increasing evidence that the alteration of antioxidant enzymes such as manganese superoxide dismutase (MnSOD) might be implicated in the development of schizophrenia and/or tardive dyskinesia (TD). This study investigated the association of a MnSOD gene (MnSOD) polymorphism (Ala-9Val) with schizophrenia as well as its involvement in TD. Patients with schizophrenia (n = 262) and healthy controls (n = 263) were enrolled in this study and genotyped by a polymerase chain reaction-based method. The distribution of the MnSOD genotypes and alleles was not significantly different between patients and controls. Logistic regression analysis also failed to reveal any association between MnSOD genotypes and TD. Taken together, these results suggest that the MnSOD polymorphism does not contribute to the development of schizophrenia and/or TD, at least in the Korean population.

Original language	English
Pages (from-to)	77-81
Number of pages	5
Journal	Psychiatry Research
Volume	153
Issue number	1
DOIs	https://doi.org/10.1016/j.psychres.2006.04.011
State	Published - 30 Sep 2007

Bibliographical note

Funding Information:
This study was supported by a grant of the Korean Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (HMP-00-GN-01-0002).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Korean
Manganese superoxide dismutase
Polymorphism
Schizophrenia
Tardive dyskinesia

Access to Document

10.1016/j.psychres.2006.04.011

Cite this

@article{aef3527bf44a47db9de28234a320be9f,

title = "Manganese superoxide dismutase (MnSOD: Ala-9Val) gene polymorphism may not be associated with schizophrenia and tardive dyskinesia",

abstract = "There has been increasing evidence that the alteration of antioxidant enzymes such as manganese superoxide dismutase (MnSOD) might be implicated in the development of schizophrenia and/or tardive dyskinesia (TD). This study investigated the association of a MnSOD gene (MnSOD) polymorphism (Ala-9Val) with schizophrenia as well as its involvement in TD. Patients with schizophrenia (n = 262) and healthy controls (n = 263) were enrolled in this study and genotyped by a polymerase chain reaction-based method. The distribution of the MnSOD genotypes and alleles was not significantly different between patients and controls. Logistic regression analysis also failed to reveal any association between MnSOD genotypes and TD. Taken together, these results suggest that the MnSOD polymorphism does not contribute to the development of schizophrenia and/or TD, at least in the Korean population.",

keywords = "Korean, Manganese superoxide dismutase, Polymorphism, Schizophrenia, Tardive dyskinesia",

author = "Pae, \{Chi Un\} and Kim, \{Tae Suk\} and Patkar, \{Ashwin A.\} and Kim, \{Jung Jin\} and Lee, \{Chang Uk\} and Lee, \{Soo Jung\} and Jun, \{Tae Youn\} and Chul Lee and Paik, \{In Ho\}",

note = "Funding Information: This study was supported by a grant of the Korean Health 21 R\&D Project, Ministry of Health and Welfare, Republic of Korea (HMP-00-GN-01-0002).",

year = "2007",

month = sep,

day = "30",

doi = "10.1016/j.psychres.2006.04.011",

language = "English",

volume = "153",

pages = "77--81",

journal = "Psychiatry Research",

issn = "0165-1781",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Manganese superoxide dismutase (MnSOD: Ala-9Val) gene polymorphism may not be associated with schizophrenia and tardive dyskinesia

AU - Pae, Chi Un

AU - Kim, Tae Suk

AU - Patkar, Ashwin A.

AU - Kim, Jung Jin

AU - Lee, Chang Uk

AU - Lee, Soo Jung

AU - Jun, Tae Youn

AU - Lee, Chul

AU - Paik, In Ho

N1 - Funding Information: This study was supported by a grant of the Korean Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (HMP-00-GN-01-0002).

PY - 2007/9/30

Y1 - 2007/9/30

N2 - There has been increasing evidence that the alteration of antioxidant enzymes such as manganese superoxide dismutase (MnSOD) might be implicated in the development of schizophrenia and/or tardive dyskinesia (TD). This study investigated the association of a MnSOD gene (MnSOD) polymorphism (Ala-9Val) with schizophrenia as well as its involvement in TD. Patients with schizophrenia (n = 262) and healthy controls (n = 263) were enrolled in this study and genotyped by a polymerase chain reaction-based method. The distribution of the MnSOD genotypes and alleles was not significantly different between patients and controls. Logistic regression analysis also failed to reveal any association between MnSOD genotypes and TD. Taken together, these results suggest that the MnSOD polymorphism does not contribute to the development of schizophrenia and/or TD, at least in the Korean population.

AB - There has been increasing evidence that the alteration of antioxidant enzymes such as manganese superoxide dismutase (MnSOD) might be implicated in the development of schizophrenia and/or tardive dyskinesia (TD). This study investigated the association of a MnSOD gene (MnSOD) polymorphism (Ala-9Val) with schizophrenia as well as its involvement in TD. Patients with schizophrenia (n = 262) and healthy controls (n = 263) were enrolled in this study and genotyped by a polymerase chain reaction-based method. The distribution of the MnSOD genotypes and alleles was not significantly different between patients and controls. Logistic regression analysis also failed to reveal any association between MnSOD genotypes and TD. Taken together, these results suggest that the MnSOD polymorphism does not contribute to the development of schizophrenia and/or TD, at least in the Korean population.

KW - Korean

KW - Manganese superoxide dismutase

KW - Polymorphism

KW - Schizophrenia

KW - Tardive dyskinesia

UR - https://www.scopus.com/pages/publications/34548496872

U2 - 10.1016/j.psychres.2006.04.011

DO - 10.1016/j.psychres.2006.04.011

M3 - Article

C2 - 17582511

AN - SCOPUS:34548496872

SN - 0165-1781

VL - 153

SP - 77

EP - 81

JO - Psychiatry Research

JF - Psychiatry Research

IS - 1

ER -

Manganese superoxide dismutase (MnSOD: Ala-9Val) gene polymorphism may not be associated with schizophrenia and tardive dyskinesia

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this