Meaningful clinical information for impending rupture in tubal pregnancy

Purpose of investigation: This study provides valuable information to help clinician's decision for treatment modality that patients with tubal pregnancy are at risk for impending rupture. Materials and Methods: This was a retrospective study of patients diagnosed with tubal pregnancy between January 2001 and September 2010. The definite diagnosis of tubal pregnancy was confirmed intraoperatively. Results: This study recruited 495 women with tubal pregnancy. Of these, 162 (33.7%) had ruptured tubal pregnancies and 333 (67.3%) had unruptured tubal pregnancies. Multivariate logistic regression analysis revealed that gestational age > 8 weeks (odds ratio (OR): 4.69), beta-subunit human chorionic gonadotropin (s-hCG, > 5,000 mIU/ml, OR: 2.43), and tubal mass size > 30 mm (OR: 12.09) were significant increased incidence for rupture of tubal pregnancy. Conclusion: The advanced gestational age is important factor, but the tubal mass size with elevated s-hCG level were the more meaningful risk factors for rupture of tubal pregnancy.