Metallo-β-lactamase-producing Pseudomonas spp. in Korea: High prevalence of isolates with VIM-2 type and emergence of isolates with IMP-1 type

Kyungwon Lee; Ae Ja Park; Moon Yeun Kim; Hee Joo Lee; Ji Hyun Cho; Jung Oak Kang; Dongeun Yong; Yunsop Chong; Namhee Ryoon; Seok Hoon Jeong; Gyoung Yim Ha; Mi Na Kim; Wee Gyo Lee; Young Ae Hong; Soung Eun Cho; Young Uh; Sook Jin Jang; Myung Hee Lee; Wonkeun Song; Tae Yeal Choi; Jong Hee Shin; Seong Geun Hong; Young Ah Kim; Dong Hee Cho; Dong Hee Whang; Seungok Lee; Seonghee Lee

doi:10.3349/ymj.2009.50.3.335

Metallo-β-lactamase-producing Pseudomonas spp. in Korea: High prevalence of isolates with VIM-2 type and emergence of isolates with IMP-1 type

Kyungwon Lee, Ae Ja Park, Moon Yeun Kim, Hee Joo Lee, Ji Hyun Cho, Jung Oak Kang, Dongeun Yong, Yunsop Chong, Namhee Ryoon, Seok Hoon Jeong, Gyoung Yim Ha, Mi Na Kim, Wee Gyo Lee, Young Ae Hong, Soung Eun Cho, Young Uh, Sook Jin Jang, Myung Hee Lee, Wonkeun Song, Tae Yeal ChoiJong Hee Shin, Seong Geun Hong, Young Ah Kim, Dong Hee Cho, Dong Hee Whang, Seungok Lee, Seonghee Lee

Department of Laboratory Medicine

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Purpose: Two Korean nationwide studies showed that metallo-β-lactamases (MBLs)-producing-Pseudomonas spp. are not rare. The aim of this study was to assess the trends of MBL-producing isolates among imipenem-resistant isolates of Pseudomonas spp. Materials and Methods: Imipenem-resistant clinical isolates were collected from 23 hospitals and one commercial laboratory participating in the KONSAR program in 2005. Polymerase chain reaction (PCR) was used to detect MBL genes. Results: Alleles of MBL genes were detected in 10.8% of 415 Pseudomonas aeruginosa and 66.7% of 12 P. putida isolates from 18 of 24 hospitals/ laboratory. Among the 14 IMP-1-like and 39 VIM-2-like MBLs, emergence of IMP-6 was detected for the first time. Conclusion: Prevalence of MBL-producing P. aeruginosa has not significantly increased, but IMP-6 emerged in P. aeruginosa.

Original language	English
Pages (from-to)	335-339
Number of pages	5
Journal	Yonsei Medical Journal
Volume	50
Issue number	3
DOIs	https://doi.org/10.3349/ymj.2009.50.3.335
State	Published - 2009

Keywords

IMP-1
IMP-6
Korea
Metallo-β-lactamase
VIM-2

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Lee, K., Park, A. J., Kim, M. Y., Lee, H. J., Cho, J. H., Kang, J. O., Yong, D., Chong, Y., Ryoon, N., Jeong, S. H., Ha, G. Y., Kim, M. N., Lee, W. G., Hong, Y. A., Cho, S. E., Uh, Y., Jang, S. J., Lee, M. H., Song, W., ... Lee, S. (2009). Metallo-β-lactamase-producing Pseudomonas spp. in Korea: High prevalence of isolates with VIM-2 type and emergence of isolates with IMP-1 type. Yonsei Medical Journal, 50(3), 335-339. https://doi.org/10.3349/ymj.2009.50.3.335

@article{8e4ba30eb1f3480f92d0ba4824c5b737,

title = "Metallo-β-lactamase-producing Pseudomonas spp. in Korea: High prevalence of isolates with VIM-2 type and emergence of isolates with IMP-1 type",

abstract = "Purpose: Two Korean nationwide studies showed that metallo-β-lactamases (MBLs)-producing-Pseudomonas spp. are not rare. The aim of this study was to assess the trends of MBL-producing isolates among imipenem-resistant isolates of Pseudomonas spp. Materials and Methods: Imipenem-resistant clinical isolates were collected from 23 hospitals and one commercial laboratory participating in the KONSAR program in 2005. Polymerase chain reaction (PCR) was used to detect MBL genes. Results: Alleles of MBL genes were detected in 10.8% of 415 Pseudomonas aeruginosa and 66.7% of 12 P. putida isolates from 18 of 24 hospitals/ laboratory. Among the 14 IMP-1-like and 39 VIM-2-like MBLs, emergence of IMP-6 was detected for the first time. Conclusion: Prevalence of MBL-producing P. aeruginosa has not significantly increased, but IMP-6 emerged in P. aeruginosa.",

keywords = "IMP-1, IMP-6, Korea, Metallo-β-lactamase, VIM-2",

author = "Kyungwon Lee and Park, {Ae Ja} and Kim, {Moon Yeun} and Lee, {Hee Joo} and Cho, {Ji Hyun} and Kang, {Jung Oak} and Dongeun Yong and Yunsop Chong and Namhee Ryoon and Jeong, {Seok Hoon} and Ha, {Gyoung Yim} and Kim, {Mi Na} and Lee, {Wee Gyo} and Hong, {Young Ae} and Cho, {Soung Eun} and Young Uh and Jang, {Sook Jin} and Lee, {Myung Hee} and Wonkeun Song and Choi, {Tae Yeal} and Shin, {Jong Hee} and Hong, {Seong Geun} and Kim, {Young Ah} and Cho, {Dong Hee} and Whang, {Dong Hee} and Seungok Lee and Seonghee Lee",

year = "2009",

doi = "10.3349/ymj.2009.50.3.335",

language = "English",

volume = "50",

pages = "335--339",

journal = "Yonsei Medical Journal",

issn = "0513-5796",

publisher = "Yonsei University College of Medicine",

number = "3",

}

Lee, K, Park, AJ, Kim, MY, Lee, HJ, Cho, JH, Kang, JO, Yong, D, Chong, Y, Ryoon, N, Jeong, SH, Ha, GY, Kim, MN, Lee, WG, Hong, YA, Cho, SE, Uh, Y, Jang, SJ, Lee, MH, Song, W, Choi, TY, Shin, JH, Hong, SG, Kim, YA, Cho, DH, Whang, DH, Lee, S & Lee, S 2009, 'Metallo-β-lactamase-producing Pseudomonas spp. in Korea: High prevalence of isolates with VIM-2 type and emergence of isolates with IMP-1 type', Yonsei Medical Journal, vol. 50, no. 3, pp. 335-339. https://doi.org/10.3349/ymj.2009.50.3.335

TY - JOUR

T1 - Metallo-β-lactamase-producing Pseudomonas spp. in Korea

T2 - High prevalence of isolates with VIM-2 type and emergence of isolates with IMP-1 type

AU - Lee, Kyungwon

AU - Park, Ae Ja

AU - Kim, Moon Yeun

AU - Lee, Hee Joo

AU - Cho, Ji Hyun

AU - Kang, Jung Oak

AU - Yong, Dongeun

AU - Chong, Yunsop

AU - Ryoon, Namhee

AU - Jeong, Seok Hoon

AU - Ha, Gyoung Yim

AU - Kim, Mi Na

AU - Lee, Wee Gyo

AU - Hong, Young Ae

AU - Cho, Soung Eun

AU - Uh, Young

AU - Jang, Sook Jin

AU - Lee, Myung Hee

AU - Song, Wonkeun

AU - Choi, Tae Yeal

AU - Shin, Jong Hee

AU - Hong, Seong Geun

AU - Kim, Young Ah

AU - Cho, Dong Hee

AU - Whang, Dong Hee

AU - Lee, Seungok

AU - Lee, Seonghee

PY - 2009

Y1 - 2009

N2 - Purpose: Two Korean nationwide studies showed that metallo-β-lactamases (MBLs)-producing-Pseudomonas spp. are not rare. The aim of this study was to assess the trends of MBL-producing isolates among imipenem-resistant isolates of Pseudomonas spp. Materials and Methods: Imipenem-resistant clinical isolates were collected from 23 hospitals and one commercial laboratory participating in the KONSAR program in 2005. Polymerase chain reaction (PCR) was used to detect MBL genes. Results: Alleles of MBL genes were detected in 10.8% of 415 Pseudomonas aeruginosa and 66.7% of 12 P. putida isolates from 18 of 24 hospitals/ laboratory. Among the 14 IMP-1-like and 39 VIM-2-like MBLs, emergence of IMP-6 was detected for the first time. Conclusion: Prevalence of MBL-producing P. aeruginosa has not significantly increased, but IMP-6 emerged in P. aeruginosa.

AB - Purpose: Two Korean nationwide studies showed that metallo-β-lactamases (MBLs)-producing-Pseudomonas spp. are not rare. The aim of this study was to assess the trends of MBL-producing isolates among imipenem-resistant isolates of Pseudomonas spp. Materials and Methods: Imipenem-resistant clinical isolates were collected from 23 hospitals and one commercial laboratory participating in the KONSAR program in 2005. Polymerase chain reaction (PCR) was used to detect MBL genes. Results: Alleles of MBL genes were detected in 10.8% of 415 Pseudomonas aeruginosa and 66.7% of 12 P. putida isolates from 18 of 24 hospitals/ laboratory. Among the 14 IMP-1-like and 39 VIM-2-like MBLs, emergence of IMP-6 was detected for the first time. Conclusion: Prevalence of MBL-producing P. aeruginosa has not significantly increased, but IMP-6 emerged in P. aeruginosa.

KW - IMP-1

KW - IMP-6

KW - Korea

KW - Metallo-β-lactamase

KW - VIM-2

UR - http://www.scopus.com/inward/record.url?scp=67651174534&partnerID=8YFLogxK

U2 - 10.3349/ymj.2009.50.3.335

DO - 10.3349/ymj.2009.50.3.335

M3 - Article

C2 - 19568593

AN - SCOPUS:67651174534

SN - 0513-5796

VL - 50

SP - 335

EP - 339

JO - Yonsei Medical Journal

JF - Yonsei Medical Journal

IS - 3

ER -

Metallo-β-lactamase-producing Pseudomonas spp. in Korea: High prevalence of isolates with VIM-2 type and emergence of isolates with IMP-1 type

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Keywords

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