Molecular mechanisms of retinal pigment epithelium dysfunction in age-related macular degeneration

Jongmin Kim; Yeo Jin Lee; Jae Yon Won

doi:10.3390/ijms222212298

Molecular mechanisms of retinal pigment epithelium dysfunction in age-related macular degeneration

Jongmin Kim, Yeo Jin Lee, Jae Yon Won

Department of Ophthalmology

Research output: Contribution to journal › Review article › peer-review

40 Scopus citations

Abstract

The retinal pigment epithelium (RPE), situated upon Bruch’s membrane, plays multiple roles in the ocular system by interacting with photoreceptors and. Therefore, dysfunction of the RPE causes diseases related to vision loss, such as age-related macular degeneration (AMD). Despite AMD being a global cause of blindness, the pathogenesis remains unclear. Understanding the pathogenesis of AMD is the first step for its prevention and treatment. This review summarizes the common pathways of RPE dysfunction and their effect in AMD. Potential treatment strategies for AMD based on targeting the RPE have also been discussed.

Original language	English
Article number	12298
Journal	International Journal of Molecular Sciences
Volume	22
Issue number	22
DOIs	https://doi.org/10.3390/ijms222212298
State	Published - 1 Nov 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Age-related macular degeneration
Retinal pigment epithelium

Access to Document

10.3390/ijms222212298

Cite this

@article{44d758640f2543c7a526f8bcc1ffaa52,

title = "Molecular mechanisms of retinal pigment epithelium dysfunction in age-related macular degeneration",

abstract = "The retinal pigment epithelium (RPE), situated upon Bruch{\textquoteright}s membrane, plays multiple roles in the ocular system by interacting with photoreceptors and. Therefore, dysfunction of the RPE causes diseases related to vision loss, such as age-related macular degeneration (AMD). Despite AMD being a global cause of blindness, the pathogenesis remains unclear. Understanding the pathogenesis of AMD is the first step for its prevention and treatment. This review summarizes the common pathways of RPE dysfunction and their effect in AMD. Potential treatment strategies for AMD based on targeting the RPE have also been discussed.",

keywords = "Age-related macular degeneration, Retinal pigment epithelium",

author = "Jongmin Kim and Lee, {Yeo Jin} and Won, {Jae Yon}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = nov,

day = "1",

doi = "10.3390/ijms222212298",

language = "English",

volume = "22",

journal = "International Journal of Molecular Sciences",

issn = "1661-6596",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "22",

}

TY - JOUR

T1 - Molecular mechanisms of retinal pigment epithelium dysfunction in age-related macular degeneration

AU - Kim, Jongmin

AU - Lee, Yeo Jin

AU - Won, Jae Yon

PY - 2021/11/1

Y1 - 2021/11/1

N2 - The retinal pigment epithelium (RPE), situated upon Bruch’s membrane, plays multiple roles in the ocular system by interacting with photoreceptors and. Therefore, dysfunction of the RPE causes diseases related to vision loss, such as age-related macular degeneration (AMD). Despite AMD being a global cause of blindness, the pathogenesis remains unclear. Understanding the pathogenesis of AMD is the first step for its prevention and treatment. This review summarizes the common pathways of RPE dysfunction and their effect in AMD. Potential treatment strategies for AMD based on targeting the RPE have also been discussed.

AB - The retinal pigment epithelium (RPE), situated upon Bruch’s membrane, plays multiple roles in the ocular system by interacting with photoreceptors and. Therefore, dysfunction of the RPE causes diseases related to vision loss, such as age-related macular degeneration (AMD). Despite AMD being a global cause of blindness, the pathogenesis remains unclear. Understanding the pathogenesis of AMD is the first step for its prevention and treatment. This review summarizes the common pathways of RPE dysfunction and their effect in AMD. Potential treatment strategies for AMD based on targeting the RPE have also been discussed.

KW - Age-related macular degeneration

KW - Retinal pigment epithelium

UR - http://www.scopus.com/inward/record.url?scp=85118933771&partnerID=8YFLogxK

U2 - 10.3390/ijms222212298

DO - 10.3390/ijms222212298

M3 - Review article

C2 - 34830181

AN - SCOPUS:85118933771

SN - 1661-6596

VL - 22

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 22

M1 - 12298

ER -

Molecular mechanisms of retinal pigment epithelium dysfunction in age-related macular degeneration

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this