Morphea and verruca plana complicated in central diabetes insipidus

Morphea, localized scleroderma, is a connective tissue disease characterized by localized, circumscribed sclerotic patches, or plaques of the skin. The pathogenesis of morphea is still unclear. Central diabetes insipidus is a disease characterized by excessive thirst and urination. In more than half of the cases of central diabetes insipidus, the etiology is still unknown. We experienced the case of morphea and verruca plana in a 32-year old female with a history of central diabetes insipidus. Central diabetes insipidus might have influenced disrupting the homeostasis of the endocrine or immune environment. In the state of disrupted homeostasis, there might be an increased chance for morphea and disseminated verruca plana to develop easily. Based on this, we suppose the possible mechanism about the morphea and disseminated verruca plana developed in central diabetes insipidus.