MRI-visible Dilated Perivascular Space in the Brain by Age: The Human Connectome Project

Hyun Gi Kim, Na Young Shin, Yoonho Nam, Eunkyeong Yun, Uicheul Yoon, Hye Sun Lee, Kook Jin Ahn

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Background: Dilated perivascular spaces (dPVS) are associated with aging and various disorders; however, the effect of age on dPVS burden in young populations and normative data have not been fully evaluated. Purpose: To investigate the dPVS burden and provide normative data according to age in a healthy population, including children. Materials and Methods: In this retrospective study, three-dimensional T2-weighted brain MRI scans from the Human Connectome Project data sets were used for visual grading (grade 0, 1, 2, 3, 4 for 0, 1-10, 11-20, 21-40, and >40 dPVS on a single section of either hemispheric region) and automated volumetry of dPVS in basal ganglia (BGdPVS) and white matter (WMdPVS). Linear and nonlinear regression were performed to assess the association of dPVS volume with age. Optimal cutoff ages were determined with use of the maximized continuous-scale C-index. Participants were grouped by cutoff values. Linear regression was performed to assess the age-dPVS volume relationship in each age group. Normative data of dPVS visual grades were provided per age decade. Results: A total of 1789 participants (mean age, 35 years; age range, 8-100 years; 1006 female participants) were evaluated. Age was related to dPVS volume in all regression models (R2 range, 0.41-0.55; P < .001). Age-dPVS volume relationships were altered at the mid-30s and age 55 years; BGdPVS and WMdPVS volumes negatively correlated with age until the mid-30s (β, .1.2 and .7.8), then positively until age 55 years (β, 3.3 and 54.1) and beyond (β, 3.9 and 42.8; P < .001). The 90th percentile for dPVS grades was grade 1 for age 49 years and younger, grade 2 for age 50-69 years, and grade 3 for age 70 years and older (overall, grade 2) for BGdPVS, and grade 3 for age 49 years and younger and grade 4 for age 50 years and older (overall, grade 3) for WMdPVS. Conclusion: Dilated perivascular spaces (dPVS) showed a biphasic volume pattern with brain MRI, lower volumes until the mid- 30s, then higher afterward. Grades of 3 or higher and 4 might be considered pathologic dPVS in basal ganglia and white matter, respectively.

Original languageEnglish
Article numbere213254
JournalRadiology
Volume306
Issue number3
DOIs
StatePublished - Mar 2023

Bibliographical note

Funding Information:
Supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (grant numbers NRF-2020R1C1C1010435 and NRF-2021R1A2C1007831). This work was also supported by a Korea Medical Device Development Fund grant funded by the Korea government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, the Ministry of Food and Drug Safety) (project number KMDF_PR_20200901_0062, 9991006735).

Funding Information:
Acknowledgments: Data and/or research tools used in the preparation of this manuscript were obtained from the National Institute of Mental Health (NIMH) Data Archive (NDA). NDA is a collaborative informatics system created by the National Institutes of Health to provide a national resource to support and accelerate research in mental health. Data set identifier(s): NIMH Data Archive Collection ID(s) or NIMH Data Archive Digital Object Identifier (DOI). Data were provided in part by the Human Connectome Project, WU-Minn Consortium (1U54MH091657) funded by the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research; and by the McDonnell Center for Systems Neuroscience at Washington University.

Publisher Copyright:
© RSNA, 2022.

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