Multimeric grain-marked micelles for highly efficient photodynamic therapy and magnetic resonance imaging of tumors

Ung Yeol Lee; Young Taik Oh; Dongin Kim; Eun Seong Lee

doi:10.1016/j.ijpharm.2014.05.028

Multimeric grain-marked micelles for highly efficient photodynamic therapy and magnetic resonance imaging of tumors

Ung Yeol Lee, Young Taik Oh, Dongin Kim, Eun Seong Lee

Department of Biomedical-Chemical Engineering

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Multimeric grain-marked micelles consisting of an inner core micelle (for Fe₃O₄ encapsulation) and outer multi-grain micelles (for chlorin e6 (Ce6, a model drug) encapsulation) were fabricated using a micelle-to-micelle conjugation method. Grain micelles (mono-thiol functionalized micelles) were chemically linked to the surface of the core micelle (multi-maleimide functionalized micelle). These micelles enable discrete compartments for Ce6 and iron oxide (Fe₃O₄) that enable a significantly increased in vivo photodynamic tumor inhibition while preserving high contrast magnetic resonance (MR) imaging of the tumor in vivo.

Original language	English
Pages (from-to)	166-172
Number of pages	7
Journal	International Journal of Pharmaceutics
Volume	471
Issue number	1-2
DOIs	https://doi.org/10.1016/j.ijpharm.2014.05.028
State	Published - 25 Aug 2014

Bibliographical note

Funding Information:
This work was financially supported by a grant of the Korean Health Technology R&D Project, Ministry of Health & Welfare (No. A111291 ).

Keywords

Chlorin e6 (Ce6)
Grain-marked micelles
Magnetic resonance imaging
Multimeric micelles
Photodynamic therapy

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10.1016/j.ijpharm.2014.05.028

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title = "Multimeric grain-marked micelles for highly efficient photodynamic therapy and magnetic resonance imaging of tumors",

abstract = "Multimeric grain-marked micelles consisting of an inner core micelle (for Fe3O4 encapsulation) and outer multi-grain micelles (for chlorin e6 (Ce6, a model drug) encapsulation) were fabricated using a micelle-to-micelle conjugation method. Grain micelles (mono-thiol functionalized micelles) were chemically linked to the surface of the core micelle (multi-maleimide functionalized micelle). These micelles enable discrete compartments for Ce6 and iron oxide (Fe3O4) that enable a significantly increased in vivo photodynamic tumor inhibition while preserving high contrast magnetic resonance (MR) imaging of the tumor in vivo.",

keywords = "Chlorin e6 (Ce6), Grain-marked micelles, Magnetic resonance imaging, Multimeric micelles, Photodynamic therapy",

author = "Lee, \{Ung Yeol\} and Oh, \{Young Taik\} and Dongin Kim and Lee, \{Eun Seong\}",

note = "Funding Information: This work was financially supported by a grant of the Korean Health Technology R\&D Project, Ministry of Health \& Welfare (No. A111291 ). ",

year = "2014",

month = aug,

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doi = "10.1016/j.ijpharm.2014.05.028",

language = "English",

volume = "471",

pages = "166--172",

journal = "International Journal of Pharmaceutics",

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TY - JOUR

T1 - Multimeric grain-marked micelles for highly efficient photodynamic therapy and magnetic resonance imaging of tumors

AU - Lee, Ung Yeol

AU - Oh, Young Taik

AU - Kim, Dongin

AU - Lee, Eun Seong

N1 - Funding Information: This work was financially supported by a grant of the Korean Health Technology R&D Project, Ministry of Health & Welfare (No. A111291 ).

PY - 2014/8/25

Y1 - 2014/8/25

N2 - Multimeric grain-marked micelles consisting of an inner core micelle (for Fe3O4 encapsulation) and outer multi-grain micelles (for chlorin e6 (Ce6, a model drug) encapsulation) were fabricated using a micelle-to-micelle conjugation method. Grain micelles (mono-thiol functionalized micelles) were chemically linked to the surface of the core micelle (multi-maleimide functionalized micelle). These micelles enable discrete compartments for Ce6 and iron oxide (Fe3O4) that enable a significantly increased in vivo photodynamic tumor inhibition while preserving high contrast magnetic resonance (MR) imaging of the tumor in vivo.

AB - Multimeric grain-marked micelles consisting of an inner core micelle (for Fe3O4 encapsulation) and outer multi-grain micelles (for chlorin e6 (Ce6, a model drug) encapsulation) were fabricated using a micelle-to-micelle conjugation method. Grain micelles (mono-thiol functionalized micelles) were chemically linked to the surface of the core micelle (multi-maleimide functionalized micelle). These micelles enable discrete compartments for Ce6 and iron oxide (Fe3O4) that enable a significantly increased in vivo photodynamic tumor inhibition while preserving high contrast magnetic resonance (MR) imaging of the tumor in vivo.

KW - Chlorin e6 (Ce6)

KW - Grain-marked micelles

KW - Magnetic resonance imaging

KW - Multimeric micelles

KW - Photodynamic therapy

UR - https://www.scopus.com/pages/publications/84901835314

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DO - 10.1016/j.ijpharm.2014.05.028

M3 - Article

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AN - SCOPUS:84901835314

SN - 0378-5173

VL - 471

SP - 166

EP - 172

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1-2

ER -

Multimeric grain-marked micelles for highly efficient photodynamic therapy and magnetic resonance imaging of tumors

Abstract

Bibliographical note

Keywords

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