Multiparametric quantification of T1 and T2 relaxation time of bone metastasis in comparison with red or fatty bone marrow using magnetic resonance fingerprinting

Objectives: To assess the T1 and T2 values of bone marrow lesions in spine and pelvis derived from magnetic resonance fingerprinting (MRF) and to evaluate the differences in values among bone metastasis, red marrow and fatty marrow. Methods: Sixty patients who underwent lumbar spine and pelvic MRI with magnetic resonance fingerprinting were retrospectively included. Among eligible patients, those with bone metastasis, benign red marrow deposition and normal fatty marrow were identified. Two radiologists independently measured the T1 and T2 values from metastatic bone lesions, fatty marrow, and red marrow deposition on three-dimensional-magnetic resonance fingerprinting. Intergroup comparison and interobserver agreement were analyzed. Results: T1 relaxation time was significantly higher in osteoblastic metastasis than in red marrow (1674.6 ± 436.3 vs 858.7 ± 319.5, p <.001). Intraclass correlation coefficients for T1 and T2 values were 0.96 (p < 0.001) and 0.83 (p < 0.001), respectively. T2 relaxation time of osteoblastic metastasis and red marrow deposition had no evidence of a difference (osteoblastic metastasis, 57.9 ± 25.0 vs red marrow, 58.0 ± 34.4, p = 0.45), as were the average T2 values of osteolytic metastasis and red marrow deposition (osteolytic metastasis, 45.3 ± 15.1 vs red marrow, 58.0 ± 34.4, p = 0.63). Conclusions: We report the feasibility of three-dimensional-magnetic resonance fingerprinting based quantification of bone marrow to differentiate bone metastasis from red marrow. Simultaneous T1 and T2 quantification of metastasis and red marrow deposition was possible in spine and pelvis and showed significant different values with excellent inter-reader agreement. Advance in knowledge: T1 values from three-dimensional-magnetic resonance fingerprinting might be a useful quantifier for evaluating bone marrow lesions.