Mutations in gyrA and gyrB in moxifloxacin-resistant mycobacterium avium complex and mycobacterium abscessus complex clinical isolates

Su Young Kim; Byung Woo Jhun; Seong Mi Moon; Sun Hye Shin; Kyeongman Jeon; O. Jung Kwon; In Young Yoo; Hee Jae Huh; Chang Seok Ki; Nam Yong Lee; Sung Jae Shin; Charles L. Daley; Gee Young Suh; Won Jung Koh

doi:10.1128/AAC.00527-18

Mutations in gyrA and gyrB in moxifloxacin-resistant mycobacterium avium complex and mycobacterium abscessus complex clinical isolates

Su Young Kim
, Byung Woo Jhun
, Seong Mi Moon
, Sun Hye Shin
, Kyeongman Jeon
, O. Jung Kwon
, In Young Yoo
, Hee Jae Huh
, Chang Seok Ki
, Nam Yong Lee
, Sung Jae Shin
, Charles L. Daley
, Gee Young Suh
, Won Jung Koh

Department of Laboratory Medicine

Sungkyunkwan University
Yonsei University
National Jewish Health

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Data on the frequency of gyrA and gyrB mutations in fluoroquinolone-resistant isolates of the Mycobacterium avium complex (MAC) and the Mycobacterium abscessus complex (MABC) are limited. In our analysis, we did not find any resistance-associated mutations in gyrA or gyrB in 105 MAC or MABC clinical isolates, including 72 moxifloxacin-resistant isolates. Our findings suggest that mechanisms other than gyrA and gyrB mutations contribute to moxifloxacin resistance in these organisms.

Original language	English
Article number	e00527-18
Journal	Antimicrobial Agents and Chemotherapy
Volume	62
Issue number	9
DOIs	https://doi.org/10.1128/AAC.00527-18
State	Published - Sep 2018

Bibliographical note

Publisher Copyright:
Copyright © 2018 American Society for Microbiology. All Rights Reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Gyrase mutation
Moxifloxacin
Mycobacterium abscessus complex
Mycobacterium avium complex
Resistance

Access to Document

10.1128/AAC.00527-18

Cite this

Kim, S. Y., Jhun, B. W., Moon, S. M., Shin, S. H., Jeon, K., Jung Kwon, O., Yoo, I. Y., Huh, H. J., Ki, C. S., Lee, N. Y., Shin, S. J., Daley, C. L., Suh, G. Y., & Koh, W. J. (2018). Mutations in gyrA and gyrB in moxifloxacin-resistant mycobacterium avium complex and mycobacterium abscessus complex clinical isolates. Antimicrobial Agents and Chemotherapy, 62(9), Article e00527-18. https://doi.org/10.1128/AAC.00527-18

@article{abad7f464cfe4cc3aa16ff2b00fed363,

title = "Mutations in gyrA and gyrB in moxifloxacin-resistant mycobacterium avium complex and mycobacterium abscessus complex clinical isolates",

abstract = "Data on the frequency of gyrA and gyrB mutations in fluoroquinolone-resistant isolates of the Mycobacterium avium complex (MAC) and the Mycobacterium abscessus complex (MABC) are limited. In our analysis, we did not find any resistance-associated mutations in gyrA or gyrB in 105 MAC or MABC clinical isolates, including 72 moxifloxacin-resistant isolates. Our findings suggest that mechanisms other than gyrA and gyrB mutations contribute to moxifloxacin resistance in these organisms.",

keywords = "Gyrase mutation, Moxifloxacin, Mycobacterium abscessus complex, Mycobacterium avium complex, Resistance",

author = "Kim, \{Su Young\} and Jhun, \{Byung Woo\} and Moon, \{Seong Mi\} and Shin, \{Sun Hye\} and Kyeongman Jeon and \{Jung Kwon\}, O. and Yoo, \{In Young\} and Huh, \{Hee Jae\} and Ki, \{Chang Seok\} and Lee, \{Nam Yong\} and Shin, \{Sung Jae\} and Daley, \{Charles L.\} and Suh, \{Gee Young\} and Koh, \{Won Jung\}",

year = "2018",

month = sep,

doi = "10.1128/AAC.00527-18",

language = "English",

volume = "62",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "9",

}

Kim, SY, Jhun, BW, Moon, SM, Shin, SH, Jeon, K, Jung Kwon, O, Yoo, IY, Huh, HJ, Ki, CS, Lee, NY, Shin, SJ, Daley, CL, Suh, GY & Koh, WJ 2018, 'Mutations in gyrA and gyrB in moxifloxacin-resistant mycobacterium avium complex and mycobacterium abscessus complex clinical isolates', Antimicrobial Agents and Chemotherapy, vol. 62, no. 9, e00527-18. https://doi.org/10.1128/AAC.00527-18

TY - JOUR

T1 - Mutations in gyrA and gyrB in moxifloxacin-resistant mycobacterium avium complex and mycobacterium abscessus complex clinical isolates

AU - Kim, Su Young

AU - Jhun, Byung Woo

AU - Moon, Seong Mi

AU - Shin, Sun Hye

AU - Jeon, Kyeongman

AU - Jung Kwon, O.

AU - Yoo, In Young

AU - Huh, Hee Jae

AU - Ki, Chang Seok

AU - Lee, Nam Yong

AU - Shin, Sung Jae

AU - Daley, Charles L.

AU - Suh, Gee Young

AU - Koh, Won Jung

PY - 2018/9

Y1 - 2018/9

N2 - Data on the frequency of gyrA and gyrB mutations in fluoroquinolone-resistant isolates of the Mycobacterium avium complex (MAC) and the Mycobacterium abscessus complex (MABC) are limited. In our analysis, we did not find any resistance-associated mutations in gyrA or gyrB in 105 MAC or MABC clinical isolates, including 72 moxifloxacin-resistant isolates. Our findings suggest that mechanisms other than gyrA and gyrB mutations contribute to moxifloxacin resistance in these organisms.

AB - Data on the frequency of gyrA and gyrB mutations in fluoroquinolone-resistant isolates of the Mycobacterium avium complex (MAC) and the Mycobacterium abscessus complex (MABC) are limited. In our analysis, we did not find any resistance-associated mutations in gyrA or gyrB in 105 MAC or MABC clinical isolates, including 72 moxifloxacin-resistant isolates. Our findings suggest that mechanisms other than gyrA and gyrB mutations contribute to moxifloxacin resistance in these organisms.

KW - Gyrase mutation

KW - Moxifloxacin

KW - Mycobacterium abscessus complex

KW - Mycobacterium avium complex

KW - Resistance

UR - https://www.scopus.com/pages/publications/85052236237

U2 - 10.1128/AAC.00527-18

DO - 10.1128/AAC.00527-18

M3 - Article

C2 - 29914959

AN - SCOPUS:85052236237

SN - 0066-4804

VL - 62

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 9

M1 - e00527-18

ER -

Mutations in gyrA and gyrB in moxifloxacin-resistant mycobacterium avium complex and mycobacterium abscessus complex clinical isolates

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this