Neutralizing Antibodies to Severe Fever With Thrombocytopenia Syndrome Virus Among Survivors, Non-Survivors and Healthy Residents in South Korea

Jeong Rae Yoo; Jae Yong Kim; Sang Taek Heo; Jihye Kim; Hyeong Jun Park; Joo Yeon Lee; Hee Young Lim; Woo Jung Park; Nam Hyuk Cho; Jung Mogg Kim; Jae Hwan Nam; Keun Hwa Lee

doi:10.3389/fcimb.2021.649570

Neutralizing Antibodies to Severe Fever With Thrombocytopenia Syndrome Virus Among Survivors, Non-Survivors and Healthy Residents in South Korea

Jeong Rae Yoo
, Jae Yong Kim
, Sang Taek Heo
, Jihye Kim
, Hyeong Jun Park
, Joo Yeon Lee
, Hee Young Lim
, Woo Jung Park
, Nam Hyuk Cho
, Jung Mogg Kim
, Jae Hwan Nam
, Keun Hwa Lee

Department of Medical and Biological Sciences

Jeju National University
The Catholic University of Korea
Kyung Hee University
Korea National Institute of Health
Seoul National University
Hanyang University

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Severe fever with thrombocytopenia syndrome (SFTS), a newly emerging tick-borne viral disease, has been detected in Asia since 2009, and person-to-person transmission is possible. SFTS is characterized by atypical signs, including mild to severe febrile illness similar to that associated with hemorrhagic fever, with 16.2 to 30% mortality. We found that the titers of neutralizing antibodies, play an important role in protective immunity, to SFTS virus (SFTSV) in survivors and healthy residents who lived in endemic areas and who were positive for SFTSV IgG, were higher than those in non-survivor patients. Moreover, the titers were maintained in surviving patients and healthy residents but not in non-surviving patients in South Korea.

Original language	English
Article number	649570
Journal	Frontiers in Cellular and Infection Microbiology
Volume	11
DOIs	https://doi.org/10.3389/fcimb.2021.649570
State	Published - 23 Mar 2021

Bibliographical note

Publisher Copyright:
© Copyright © 2021 Yoo, Kim, Heo, Kim, Park, Lee, Lim, Park, Cho, Kim, Nam and Lee.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

SFTSV
South Korea
healthy residents
neutralizing antibodies
non-survivors
survivors

Access to Document

10.3389/fcimb.2021.649570

Cite this

Yoo, J. R., Kim, J. Y., Heo, S. T., Kim, J., Park, H. J., Lee, J. Y., Lim, H. Y., Park, W. J., Cho, N. H., Kim, J. M., Nam, J. H., & Lee, K. H. (2021). Neutralizing Antibodies to Severe Fever With Thrombocytopenia Syndrome Virus Among Survivors, Non-Survivors and Healthy Residents in South Korea. Frontiers in Cellular and Infection Microbiology, 11, Article 649570. https://doi.org/10.3389/fcimb.2021.649570

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title = "Neutralizing Antibodies to Severe Fever With Thrombocytopenia Syndrome Virus Among Survivors, Non-Survivors and Healthy Residents in South Korea",

abstract = "Severe fever with thrombocytopenia syndrome (SFTS), a newly emerging tick-borne viral disease, has been detected in Asia since 2009, and person-to-person transmission is possible. SFTS is characterized by atypical signs, including mild to severe febrile illness similar to that associated with hemorrhagic fever, with 16.2 to 30\% mortality. We found that the titers of neutralizing antibodies, play an important role in protective immunity, to SFTS virus (SFTSV) in survivors and healthy residents who lived in endemic areas and who were positive for SFTSV IgG, were higher than those in non-survivor patients. Moreover, the titers were maintained in surviving patients and healthy residents but not in non-surviving patients in South Korea.",

keywords = "SFTSV, South Korea, healthy residents, neutralizing antibodies, non-survivors, survivors",

author = "Yoo, \{Jeong Rae\} and Kim, \{Jae Yong\} and Heo, \{Sang Taek\} and Jihye Kim and Park, \{Hyeong Jun\} and Lee, \{Joo Yeon\} and Lim, \{Hee Young\} and Park, \{Woo Jung\} and Cho, \{Nam Hyuk\} and Kim, \{Jung Mogg\} and Nam, \{Jae Hwan\} and Lee, \{Keun Hwa\}",

note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Yoo, Kim, Heo, Kim, Park, Lee, Lim, Park, Cho, Kim, Nam and Lee.",

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doi = "10.3389/fcimb.2021.649570",

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Yoo, JR, Kim, JY, Heo, ST, Kim, J, Park, HJ, Lee, JY, Lim, HY, Park, WJ, Cho, NH, Kim, JM, Nam, JH & Lee, KH 2021, 'Neutralizing Antibodies to Severe Fever With Thrombocytopenia Syndrome Virus Among Survivors, Non-Survivors and Healthy Residents in South Korea', Frontiers in Cellular and Infection Microbiology, vol. 11, 649570. https://doi.org/10.3389/fcimb.2021.649570

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T1 - Neutralizing Antibodies to Severe Fever With Thrombocytopenia Syndrome Virus Among Survivors, Non-Survivors and Healthy Residents in South Korea

AU - Yoo, Jeong Rae

AU - Kim, Jae Yong

AU - Heo, Sang Taek

AU - Kim, Jihye

AU - Park, Hyeong Jun

AU - Lee, Joo Yeon

AU - Lim, Hee Young

AU - Park, Woo Jung

AU - Cho, Nam Hyuk

AU - Kim, Jung Mogg

AU - Nam, Jae Hwan

AU - Lee, Keun Hwa

PY - 2021/3/23

Y1 - 2021/3/23

N2 - Severe fever with thrombocytopenia syndrome (SFTS), a newly emerging tick-borne viral disease, has been detected in Asia since 2009, and person-to-person transmission is possible. SFTS is characterized by atypical signs, including mild to severe febrile illness similar to that associated with hemorrhagic fever, with 16.2 to 30% mortality. We found that the titers of neutralizing antibodies, play an important role in protective immunity, to SFTS virus (SFTSV) in survivors and healthy residents who lived in endemic areas and who were positive for SFTSV IgG, were higher than those in non-survivor patients. Moreover, the titers were maintained in surviving patients and healthy residents but not in non-surviving patients in South Korea.

AB - Severe fever with thrombocytopenia syndrome (SFTS), a newly emerging tick-borne viral disease, has been detected in Asia since 2009, and person-to-person transmission is possible. SFTS is characterized by atypical signs, including mild to severe febrile illness similar to that associated with hemorrhagic fever, with 16.2 to 30% mortality. We found that the titers of neutralizing antibodies, play an important role in protective immunity, to SFTS virus (SFTSV) in survivors and healthy residents who lived in endemic areas and who were positive for SFTSV IgG, were higher than those in non-survivor patients. Moreover, the titers were maintained in surviving patients and healthy residents but not in non-surviving patients in South Korea.

KW - SFTSV

KW - South Korea

KW - healthy residents

KW - neutralizing antibodies

KW - non-survivors

KW - survivors

UR - https://www.scopus.com/pages/publications/85103838111

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DO - 10.3389/fcimb.2021.649570

M3 - Article

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AN - SCOPUS:85103838111

SN - 2235-2988

VL - 11

JO - Frontiers in Cellular and Infection Microbiology

JF - Frontiers in Cellular and Infection Microbiology

M1 - 649570

ER -

Neutralizing Antibodies to Severe Fever With Thrombocytopenia Syndrome Virus Among Survivors, Non-Survivors and Healthy Residents in South Korea

Abstract

Bibliographical note

UN SDGs

Keywords

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