Newly developed porcine acellular dermal matrix (XenoDerm) for adhesion prevention and rreconstruction of aabdominal wall defect in rat

Various prosthetic materials have been employed to reconstruct abdominal wall defects. Prosthetic materials have been used widely to repair the abdominal defects; however, complications with mesh infection and adhesion have led to the recent use of more biocompatible implants derived from animal or human sources for the surgical repair of abdominal wall defects. The purpose of the present study was to evaluate the effectiveness of the newly developed acellular porcine dermis (XenoDerm) to prevent adhesion in the reconstruction of abdominal wall defects compared with human acellular dermal matrix (SureDerm™) in a rat model. Forty adult Sprague-Dawley rats underwent repair of surgically created ventral hernias using porcine, acellular dermal-matrix or human acellular dermal-matrix. The grade of adhesion (peritoneal adhesions by Hooker score and intra-abdominal adhesions by Knightly score), histologic analysis (using hematoxylin-eosin stain, Masson-trichrome stain and immunohistochemical stain) and tensile strength (by MultiTest 1-i tensiometer) were assessed, after the animals were euthanized at 1 week and at 4 week postoperatively. At 4 week after the repair of abdominal wall defect, the porcine acellular dermal matrix incorporated into the host tissue and revealed no significant difference in adhesion, histologic analysis, or tensile strength compared with the human acellular dermal matrix. Based on these results, we conclude that acellular porcine dermal matrix (XenoDerm) is useful for abdominal wall reconstruction. However, subsequent studies with longer time periods and clinical studies will be needed to reveal the consequences of its use in abdominal wall defect reconstruction.