No association of TAP2 polymorphisms in Korean patients with schizophrenia

Tae Youn Jun; Kyoung Uk Lee; Chi Un Pae; Jeong Ho Chae; Won Myong Bahk; Kwang Soo Kim; Tae Yul Lew

doi:10.1097/00041444-200409000-00011

No association of TAP2 polymorphisms in Korean patients with schizophrenia

Tae Youn Jun
, Kyoung Uk Lee
, Chi Un Pae
, Jeong Ho Chae
, Won Myong Bahk
, Kwang Soo Kim
, Tae Yul Lew

Department of Psychiatry

The Catholic University of Korea

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives: Polymorphisms of transporters associated with antigen-processing (TAP) genes might influence the susceptibility to schizophrenia by altering the antigen-processing pathway. The aim of this study was to verify the relationship between schizophrenia and the polymorphisms of TAP2 genes. Method: Two hundred and fifty-seven Korean patients diagnosed with schizophrenia according to DSM-IV and 184 normal controls participated in this study. TAP2 polymorphic residues at positions 379, 565 and 665 were typed using amplification refractory mutation system-polymerase chain reaction single-strand conformation polymorphism. Results: Distribution of the alleles and genotypes in patients with schizophrenia was not significantly different from those of controls. Conclusions: This study did not show the association of the TAP2 gene with schizophrenia in the Korean population.

Original language	English
Pages (from-to)	173-176
Number of pages	4
Journal	Psychiatric Genetics
Volume	14
Issue number	3
DOIs	https://doi.org/10.1097/00041444-200409000-00011
State	Published - Sep 2004

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Korean population
Polymorphisms
Schizophrenia
TAP2

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10.1097/00041444-200409000-00011

Cite this

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title = "No association of TAP2 polymorphisms in Korean patients with schizophrenia",

abstract = "Objectives: Polymorphisms of transporters associated with antigen-processing (TAP) genes might influence the susceptibility to schizophrenia by altering the antigen-processing pathway. The aim of this study was to verify the relationship between schizophrenia and the polymorphisms of TAP2 genes. Method: Two hundred and fifty-seven Korean patients diagnosed with schizophrenia according to DSM-IV and 184 normal controls participated in this study. TAP2 polymorphic residues at positions 379, 565 and 665 were typed using amplification refractory mutation system-polymerase chain reaction single-strand conformation polymorphism. Results: Distribution of the alleles and genotypes in patients with schizophrenia was not significantly different from those of controls. Conclusions: This study did not show the association of the TAP2 gene with schizophrenia in the Korean population.",

keywords = "Korean population, Polymorphisms, Schizophrenia, TAP2",

author = "Jun, \{Tae Youn\} and Lee, \{Kyoung Uk\} and Pae, \{Chi Un\} and Chae, \{Jeong Ho\} and Bahk, \{Won Myong\} and Kim, \{Kwang Soo\} and Lew, \{Tae Yul\}",

year = "2004",

month = sep,

doi = "10.1097/00041444-200409000-00011",

language = "English",

volume = "14",

pages = "173--176",

journal = "Psychiatric Genetics",

issn = "0955-8829",

publisher = "Lippincott Williams and Wilkins",

number = "3",

}

TY - JOUR

T1 - No association of TAP2 polymorphisms in Korean patients with schizophrenia

AU - Jun, Tae Youn

AU - Lee, Kyoung Uk

AU - Pae, Chi Un

AU - Chae, Jeong Ho

AU - Bahk, Won Myong

AU - Kim, Kwang Soo

AU - Lew, Tae Yul

PY - 2004/9

Y1 - 2004/9

N2 - Objectives: Polymorphisms of transporters associated with antigen-processing (TAP) genes might influence the susceptibility to schizophrenia by altering the antigen-processing pathway. The aim of this study was to verify the relationship between schizophrenia and the polymorphisms of TAP2 genes. Method: Two hundred and fifty-seven Korean patients diagnosed with schizophrenia according to DSM-IV and 184 normal controls participated in this study. TAP2 polymorphic residues at positions 379, 565 and 665 were typed using amplification refractory mutation system-polymerase chain reaction single-strand conformation polymorphism. Results: Distribution of the alleles and genotypes in patients with schizophrenia was not significantly different from those of controls. Conclusions: This study did not show the association of the TAP2 gene with schizophrenia in the Korean population.

AB - Objectives: Polymorphisms of transporters associated with antigen-processing (TAP) genes might influence the susceptibility to schizophrenia by altering the antigen-processing pathway. The aim of this study was to verify the relationship between schizophrenia and the polymorphisms of TAP2 genes. Method: Two hundred and fifty-seven Korean patients diagnosed with schizophrenia according to DSM-IV and 184 normal controls participated in this study. TAP2 polymorphic residues at positions 379, 565 and 665 were typed using amplification refractory mutation system-polymerase chain reaction single-strand conformation polymorphism. Results: Distribution of the alleles and genotypes in patients with schizophrenia was not significantly different from those of controls. Conclusions: This study did not show the association of the TAP2 gene with schizophrenia in the Korean population.

KW - Korean population

KW - Polymorphisms

KW - Schizophrenia

KW - TAP2

UR - https://www.scopus.com/pages/publications/4644338839

U2 - 10.1097/00041444-200409000-00011

DO - 10.1097/00041444-200409000-00011

M3 - Article

C2 - 15318034

AN - SCOPUS:4644338839

SN - 0955-8829

VL - 14

SP - 173

EP - 176

JO - Psychiatric Genetics

JF - Psychiatric Genetics

IS - 3

ER -

No association of TAP2 polymorphisms in Korean patients with schizophrenia

Abstract

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Keywords

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