Noninvasive markers to diagnose cirrhosis in patients with HBeAg positive chronic hepatitis: Do new biomarkers improve the accuracy?

Seung Ha Park; Dong Joon Kim; Jae Youn Cheong; Sung Won Cho; Seong Gyu Hwang; Youn Jae Lee; Mong Cho; Jin Mo Yang; Young Bae Kim

doi:10.1016/j.clinbiochem.2010.04.063

Noninvasive markers to diagnose cirrhosis in patients with HBeAg positive chronic hepatitis: Do new biomarkers improve the accuracy?

Seung Ha Park
, Dong Joon Kim
, Jae Youn Cheong
, Sung Won Cho
, Seong Gyu Hwang
, Youn Jae Lee
, Mong Cho
, Jin Mo Yang
, Young Bae Kim

Division of Gastroenterology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Objectives: The goal of the study was to clarify whether new biomarkers independently contribute to the diagnosis of cirrhosis. Design and methods: A total of 142 consecutive patients with HBeAg positive chronic hepatitis who underwent liver biopsy were recruited. The Cirrhosis Score (CS)-1 was derived from routine laboratory data only. The CS-2 was calculated using all correlates obtained from both routine laboratory data and 7 new biomarkers. Results: A comparison of the area under the receiver operating characteristic (ROC) curve between CS-1 [0.84 (95% CI, 0.74 to 0.94)] and CS-2 [0.86 (0.78 to 0.95)] showed no superior diagnostic accuracy of CS-2 over CS-1 (p= 0.24). Conclusions: None of the new biomarkers had value in addition to readily available laboratory data for differentiating cirrhosis from HBeAg positive chronic hepatitis B.

Original language	English
Pages (from-to)	877-881
Number of pages	5
Journal	Clinical Biochemistry
Volume	43
Issue number	10-11
DOIs	https://doi.org/10.1016/j.clinbiochem.2010.04.063
State	Published - Jul 2010

Bibliographical note

Funding Information:
This study was supported by a grant (no. A050021 ) of the Good Health R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea .

Keywords

Biomarkers
Chronic
Hepatitis B
Liver cirrhosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.clinbiochem.2010.04.063

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@article{cd8b4e524d32430dbfd4ee9e122a2a40,

title = "Noninvasive markers to diagnose cirrhosis in patients with HBeAg positive chronic hepatitis: Do new biomarkers improve the accuracy?",

abstract = "Objectives: The goal of the study was to clarify whether new biomarkers independently contribute to the diagnosis of cirrhosis. Design and methods: A total of 142 consecutive patients with HBeAg positive chronic hepatitis who underwent liver biopsy were recruited. The Cirrhosis Score (CS)-1 was derived from routine laboratory data only. The CS-2 was calculated using all correlates obtained from both routine laboratory data and 7 new biomarkers. Results: A comparison of the area under the receiver operating characteristic (ROC) curve between CS-1 [0.84 (95\% CI, 0.74 to 0.94)] and CS-2 [0.86 (0.78 to 0.95)] showed no superior diagnostic accuracy of CS-2 over CS-1 (p= 0.24). Conclusions: None of the new biomarkers had value in addition to readily available laboratory data for differentiating cirrhosis from HBeAg positive chronic hepatitis B.",

keywords = "Biomarkers, Chronic, Hepatitis B, Liver cirrhosis",

author = "Park, \{Seung Ha\} and Kim, \{Dong Joon\} and Cheong, \{Jae Youn\} and Cho, \{Sung Won\} and Hwang, \{Seong Gyu\} and Lee, \{Youn Jae\} and Mong Cho and Yang, \{Jin Mo\} and Kim, \{Young Bae\}",

note = "Funding Information: This study was supported by a grant (no. A050021 ) of the Good Health R\&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea .",

year = "2010",

month = jul,

doi = "10.1016/j.clinbiochem.2010.04.063",

language = "English",

volume = "43",

pages = "877--881",

journal = "Clinical Biochemistry",

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publisher = "Elsevier Inc.",

number = "10-11",

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TY - JOUR

T1 - Noninvasive markers to diagnose cirrhosis in patients with HBeAg positive chronic hepatitis

T2 - Do new biomarkers improve the accuracy?

AU - Park, Seung Ha

AU - Kim, Dong Joon

AU - Cheong, Jae Youn

AU - Cho, Sung Won

AU - Hwang, Seong Gyu

AU - Lee, Youn Jae

AU - Cho, Mong

AU - Yang, Jin Mo

AU - Kim, Young Bae

N1 - Funding Information: This study was supported by a grant (no. A050021 ) of the Good Health R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea .

PY - 2010/7

Y1 - 2010/7

N2 - Objectives: The goal of the study was to clarify whether new biomarkers independently contribute to the diagnosis of cirrhosis. Design and methods: A total of 142 consecutive patients with HBeAg positive chronic hepatitis who underwent liver biopsy were recruited. The Cirrhosis Score (CS)-1 was derived from routine laboratory data only. The CS-2 was calculated using all correlates obtained from both routine laboratory data and 7 new biomarkers. Results: A comparison of the area under the receiver operating characteristic (ROC) curve between CS-1 [0.84 (95% CI, 0.74 to 0.94)] and CS-2 [0.86 (0.78 to 0.95)] showed no superior diagnostic accuracy of CS-2 over CS-1 (p= 0.24). Conclusions: None of the new biomarkers had value in addition to readily available laboratory data for differentiating cirrhosis from HBeAg positive chronic hepatitis B.

AB - Objectives: The goal of the study was to clarify whether new biomarkers independently contribute to the diagnosis of cirrhosis. Design and methods: A total of 142 consecutive patients with HBeAg positive chronic hepatitis who underwent liver biopsy were recruited. The Cirrhosis Score (CS)-1 was derived from routine laboratory data only. The CS-2 was calculated using all correlates obtained from both routine laboratory data and 7 new biomarkers. Results: A comparison of the area under the receiver operating characteristic (ROC) curve between CS-1 [0.84 (95% CI, 0.74 to 0.94)] and CS-2 [0.86 (0.78 to 0.95)] showed no superior diagnostic accuracy of CS-2 over CS-1 (p= 0.24). Conclusions: None of the new biomarkers had value in addition to readily available laboratory data for differentiating cirrhosis from HBeAg positive chronic hepatitis B.

KW - Biomarkers

KW - Chronic

KW - Hepatitis B

KW - Liver cirrhosis

UR - https://www.scopus.com/pages/publications/77953706929

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DO - 10.1016/j.clinbiochem.2010.04.063

M3 - Article

C2 - 20433821

AN - SCOPUS:77953706929

SN - 0009-9120

VL - 43

SP - 877

EP - 881

JO - Clinical Biochemistry

JF - Clinical Biochemistry

IS - 10-11

ER -

Noninvasive markers to diagnose cirrhosis in patients with HBeAg positive chronic hepatitis: Do new biomarkers improve the accuracy?

Abstract

Bibliographical note

Keywords

UN SDGs

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