TY - JOUR
T1 - Notch intracellular domain expression in various skin fibroproliferative diseases
AU - Kim, Jung Eun
AU - Lee, Joo Hyun
AU - Jeong, Kwan Ho
AU - Kim, Gyong Moon
AU - Kang, Hoon
PY - 2014
Y1 - 2014
N2 - Background: The effects of the Notch signaling pathway in fibroproliferative skin diseases have not been fully elucidated. Objective: The aim of this study was to investigate the expression of activated Notch signaling molecules in various skin fibroproliferative diseases. Methods: Immunohistochemical analysis of Notch intracellular domain (NICD) expression in keloid, hypertrophic scar, morphea, dermatofibroma, and normal control skin specimens was performed, and the clinical characteristics of patients with various skin fibroproliferative diseases were analyzed. Results: NICD was highly expressed in fibroblasts of keloids and moderately to highly expressed in hypertrophic scars and dermatofibromas, whereas low or no expression was detected in the fibroblasts of normal skin specimens and morpheas. NICD was constitutively expressed in keratinocytes, endothelial cells, and immune cells in normal skin specimens. Conclusion: NICD was significantly expressed in human fibroproliferative skin disorders, especially keloids, suggesting that an activated Notch signaling pathway is involved in the pathogenesis of skin fibrosis.
AB - Background: The effects of the Notch signaling pathway in fibroproliferative skin diseases have not been fully elucidated. Objective: The aim of this study was to investigate the expression of activated Notch signaling molecules in various skin fibroproliferative diseases. Methods: Immunohistochemical analysis of Notch intracellular domain (NICD) expression in keloid, hypertrophic scar, morphea, dermatofibroma, and normal control skin specimens was performed, and the clinical characteristics of patients with various skin fibroproliferative diseases were analyzed. Results: NICD was highly expressed in fibroblasts of keloids and moderately to highly expressed in hypertrophic scars and dermatofibromas, whereas low or no expression was detected in the fibroblasts of normal skin specimens and morpheas. NICD was constitutively expressed in keratinocytes, endothelial cells, and immune cells in normal skin specimens. Conclusion: NICD was significantly expressed in human fibroproliferative skin disorders, especially keloids, suggesting that an activated Notch signaling pathway is involved in the pathogenesis of skin fibrosis.
KW - Benign fibrous histiocytoma
KW - Hypertrophic cicatrix
KW - Keloid
KW - Localized scleroderma
KW - Notch receptors
UR - https://www.scopus.com/pages/publications/84904327351
U2 - 10.5021/ad.2014.26.3.332
DO - 10.5021/ad.2014.26.3.332
M3 - Article
AN - SCOPUS:84904327351
SN - 1013-9087
VL - 26
SP - 332
EP - 337
JO - Annals of Dermatology
JF - Annals of Dermatology
IS - 3
ER -
