Obesity-induced chronic inflammation is associated with the reduced efficacy of influenza vaccine

Hye Lim Park; Seung Hyun Shim; Eun Young Lee; Whajung Cho; Sooho Park; Hyun Jung Jeon; Sun Young Ahn; Hun Kim; Jae Hwan Nam

doi:10.4161/hv.28332

Obesity-induced chronic inflammation is associated with the reduced efficacy of influenza vaccine

Hye Lim Park
, Seung Hyun Shim
, Eun Young Lee
, Whajung Cho
, Sooho Park
, Hyun Jung Jeon
, Sun Young Ahn
, Hun Kim
, Jae Hwan Nam

Department of Medical and Biological Sciences

The Catholic University of Korea
SK Corporation

Research output: Contribution to journal › Article › peer-review

99 Scopus citations

Abstract

The relationship between obesity and vaccine efficacy is a serious issue. Previous studies have shown that vaccine efficacy is lower in the obese than in the non-obese. Here, we examined the influence of obesity on the efficacy of influenza vaccination using high fat diet (HFD) and regular fat diet (RFD) mice that were immunized with 2 types of influenza virus vaccines - cell culture-based vaccines and egg-based vaccines. HFD mice showed lower levels of neutralizing antibody titers as compared with RFD mice. Moreover, HFD mice showed high levels of MCP-1 in serum and adipocytes, and low level of influenza virus-specific effector memory CD8⁺ T cells. After challenge with influenza virus, the lungs of HFD mice showed more severe inflammatory responses as compared with the lungs of RFD mice, even after vaccination. Taken together, our data suggested that the inflammatory condition in obesity may contribute to the suppressed efficacy of influenza vaccination.

Original language	English
Pages (from-to)	1181-1186
Number of pages	6
Journal	Human Vaccines and Immunotherapeutics
Volume	10
Issue number	5
DOIs	https://doi.org/10.4161/hv.28332
State	Published - May 2014

Bibliographical note

Funding Information:
This study was supported by a grant from the Korean Healthcare Technology R&D project of the Ministry of Health and Welfare (A103001), and by a grant from Gyunggi Regional Research Center (GRRC) of the Catholic University of Korea.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

High fat diet
Inflammation
Influenza virus
Obesity
Vaccine

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10.4161/hv.28332

Cite this

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title = "Obesity-induced chronic inflammation is associated with the reduced efficacy of influenza vaccine",

abstract = "The relationship between obesity and vaccine efficacy is a serious issue. Previous studies have shown that vaccine efficacy is lower in the obese than in the non-obese. Here, we examined the influence of obesity on the efficacy of influenza vaccination using high fat diet (HFD) and regular fat diet (RFD) mice that were immunized with 2 types of influenza virus vaccines - cell culture-based vaccines and egg-based vaccines. HFD mice showed lower levels of neutralizing antibody titers as compared with RFD mice. Moreover, HFD mice showed high levels of MCP-1 in serum and adipocytes, and low level of influenza virus-specific effector memory CD8+ T cells. After challenge with influenza virus, the lungs of HFD mice showed more severe inflammatory responses as compared with the lungs of RFD mice, even after vaccination. Taken together, our data suggested that the inflammatory condition in obesity may contribute to the suppressed efficacy of influenza vaccination.",

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note = "Funding Information: This study was supported by a grant from the Korean Healthcare Technology R\&D project of the Ministry of Health and Welfare (A103001), and by a grant from Gyunggi Regional Research Center (GRRC) of the Catholic University of Korea.",

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AU - Park, Hye Lim

AU - Shim, Seung Hyun

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AU - Park, Sooho

AU - Jeon, Hyun Jung

AU - Ahn, Sun Young

AU - Kim, Hun

AU - Nam, Jae Hwan

N1 - Funding Information: This study was supported by a grant from the Korean Healthcare Technology R&D project of the Ministry of Health and Welfare (A103001), and by a grant from Gyunggi Regional Research Center (GRRC) of the Catholic University of Korea.

PY - 2014/5

Y1 - 2014/5

N2 - The relationship between obesity and vaccine efficacy is a serious issue. Previous studies have shown that vaccine efficacy is lower in the obese than in the non-obese. Here, we examined the influence of obesity on the efficacy of influenza vaccination using high fat diet (HFD) and regular fat diet (RFD) mice that were immunized with 2 types of influenza virus vaccines - cell culture-based vaccines and egg-based vaccines. HFD mice showed lower levels of neutralizing antibody titers as compared with RFD mice. Moreover, HFD mice showed high levels of MCP-1 in serum and adipocytes, and low level of influenza virus-specific effector memory CD8+ T cells. After challenge with influenza virus, the lungs of HFD mice showed more severe inflammatory responses as compared with the lungs of RFD mice, even after vaccination. Taken together, our data suggested that the inflammatory condition in obesity may contribute to the suppressed efficacy of influenza vaccination.

AB - The relationship between obesity and vaccine efficacy is a serious issue. Previous studies have shown that vaccine efficacy is lower in the obese than in the non-obese. Here, we examined the influence of obesity on the efficacy of influenza vaccination using high fat diet (HFD) and regular fat diet (RFD) mice that were immunized with 2 types of influenza virus vaccines - cell culture-based vaccines and egg-based vaccines. HFD mice showed lower levels of neutralizing antibody titers as compared with RFD mice. Moreover, HFD mice showed high levels of MCP-1 in serum and adipocytes, and low level of influenza virus-specific effector memory CD8+ T cells. After challenge with influenza virus, the lungs of HFD mice showed more severe inflammatory responses as compared with the lungs of RFD mice, even after vaccination. Taken together, our data suggested that the inflammatory condition in obesity may contribute to the suppressed efficacy of influenza vaccination.

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KW - Obesity

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Obesity-induced chronic inflammation is associated with the reduced efficacy of influenza vaccine

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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