Optimal cut-off value of perfusion parameters for diagnosing prostate cancer and for assessing aggressiveness associated with Gleason score

Eunkyung Cho; Dong Jin Chung; Dong Myung Yeo; Dongwan Sohn; Yohan Son; Taejung Kim; Sung Tae Hahn

doi:10.1016/j.clinimag.2015.04.020

Optimal cut-off value of perfusion parameters for diagnosing prostate cancer and for assessing aggressiveness associated with Gleason score

Eunkyung Cho, Dong Jin Chung, Dong Myung Yeo, Dongwan Sohn, Yohan Son, Taejung Kim, Sung Tae Hahn

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

To determine cut-off value of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) parameters for differentiation of prostate malignant from benign and cancer with high-grade Gleason score (GS) (GS>7) from low-grade GS (GS≤7), 35 patients (24 malignant and 11 benign) who underwent DCE-MRI were included. Difference between malignant and benign was statistically significant for all magnetic resonance parameters except V_e. The cut-off values were K^trans=0.184min^-1, K_ep=0.695min^-1, iAUC=4.219mmol/l/min, and ADC=1340.5mm²/s. A significant difference in mean values of K^trans and K_ep between cancer with high-grade GS and low-grade GS was also observed. K^trans and K_ep showed a significant correlation with GS.

Original language	English
Pages (from-to)	834-840
Number of pages	7
Journal	Clinical Imaging
Volume	39
Issue number	5
DOIs	https://doi.org/10.1016/j.clinimag.2015.04.020
State	Published - 1 Sep 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Inc.

Keywords

Cut-off value
DCE-MRI
Gleason's score
Perfusion parameter
Prostate cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.clinimag.2015.04.020

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@article{4565b9655d654b22a93e80f32dfd10ec,

title = "Optimal cut-off value of perfusion parameters for diagnosing prostate cancer and for assessing aggressiveness associated with Gleason score",

abstract = "To determine cut-off value of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) parameters for differentiation of prostate malignant from benign and cancer with high-grade Gleason score (GS) (GS>7) from low-grade GS (GS≤7), 35 patients (24 malignant and 11 benign) who underwent DCE-MRI were included. Difference between malignant and benign was statistically significant for all magnetic resonance parameters except Ve. The cut-off values were Ktrans=0.184min-1, Kep=0.695min-1, iAUC=4.219mmol/l/min, and ADC=1340.5mm2/s. A significant difference in mean values of Ktrans and Kep between cancer with high-grade GS and low-grade GS was also observed. Ktrans and Kep showed a significant correlation with GS.",

keywords = "Cut-off value, DCE-MRI, Gleason's score, Perfusion parameter, Prostate cancer",

author = "Eunkyung Cho and Chung, {Dong Jin} and Yeo, {Dong Myung} and Dongwan Sohn and Yohan Son and Taejung Kim and Hahn, {Sung Tae}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2015",

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doi = "10.1016/j.clinimag.2015.04.020",

language = "English",

volume = "39",

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T1 - Optimal cut-off value of perfusion parameters for diagnosing prostate cancer and for assessing aggressiveness associated with Gleason score

AU - Cho, Eunkyung

AU - Chung, Dong Jin

AU - Yeo, Dong Myung

AU - Sohn, Dongwan

AU - Son, Yohan

AU - Kim, Taejung

AU - Hahn, Sung Tae

PY - 2015/9/1

Y1 - 2015/9/1

N2 - To determine cut-off value of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) parameters for differentiation of prostate malignant from benign and cancer with high-grade Gleason score (GS) (GS>7) from low-grade GS (GS≤7), 35 patients (24 malignant and 11 benign) who underwent DCE-MRI were included. Difference between malignant and benign was statistically significant for all magnetic resonance parameters except Ve. The cut-off values were Ktrans=0.184min-1, Kep=0.695min-1, iAUC=4.219mmol/l/min, and ADC=1340.5mm2/s. A significant difference in mean values of Ktrans and Kep between cancer with high-grade GS and low-grade GS was also observed. Ktrans and Kep showed a significant correlation with GS.

AB - To determine cut-off value of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) parameters for differentiation of prostate malignant from benign and cancer with high-grade Gleason score (GS) (GS>7) from low-grade GS (GS≤7), 35 patients (24 malignant and 11 benign) who underwent DCE-MRI were included. Difference between malignant and benign was statistically significant for all magnetic resonance parameters except Ve. The cut-off values were Ktrans=0.184min-1, Kep=0.695min-1, iAUC=4.219mmol/l/min, and ADC=1340.5mm2/s. A significant difference in mean values of Ktrans and Kep between cancer with high-grade GS and low-grade GS was also observed. Ktrans and Kep showed a significant correlation with GS.

KW - Cut-off value

KW - DCE-MRI

KW - Gleason's score

KW - Perfusion parameter

KW - Prostate cancer

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U2 - 10.1016/j.clinimag.2015.04.020

DO - 10.1016/j.clinimag.2015.04.020

M3 - Article

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AN - SCOPUS:84940453023

SN - 0899-7071

VL - 39

SP - 834

EP - 840

JO - Clinical Imaging

JF - Clinical Imaging

IS - 5

ER -

Optimal cut-off value of perfusion parameters for diagnosing prostate cancer and for assessing aggressiveness associated with Gleason score

Abstract

Bibliographical note

Keywords

UN SDGs

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