Orthostatic hypotension, non-dipping and striatal dopamine in Parkinson disease

Yoon Sang Oh; Joong Seok Kim; Yong An Chung; Ie Ryung You; Dong Won Yang; Sung Woo Chung; Jeong Wook Park; Yeong In Kim; Kwang Soo Lee

doi:10.1007/s10072-012-1176-9

Orthostatic hypotension, non-dipping and striatal dopamine in Parkinson disease

Yoon Sang Oh, Joong Seok Kim, Yong An Chung, Ie Ryung You, Dong Won Yang, Sung Woo Chung, Jeong Wook Park, Yeong In Kim, Kwang Soo Lee

The Catholic University of Korea

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Orthostatic hypotension and non-dipping are relatively common autonomic dysfunctions in patients with Parkinson disease (PD). These abnormalities have been thought to occur independently of striatal dopaminergic depletion; however, only little preliminary information is available. In this study, we investigated the association of neurocirculatory changes with striatal dopamine transporter status in 69 patients with early PD. Seventeen patients had orthostatic hypotension and 55 patients were non-dippers. A comparison between cases with and without orthostatic hypotension was insignificant for striatal dopamine transporter uptake. These insignificances continued in a comparison of dippers and non-dippers. These results suggest that sympathetic noradrenergic dysfunctions in PD are independent of striatal dopamine transporter depletion.

Original language	English
Pages (from-to)	557-560
Number of pages	4
Journal	Neurological Sciences
Volume	34
Issue number	4
DOIs	https://doi.org/10.1007/s10072-012-1176-9
State	Published - Apr 2013

Keywords

Motor symptoms
Non-dipping
Orthostatic hypotension
Parkinson disease
Striatal dopamine depletion

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10072-012-1176-9

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abstract = "Orthostatic hypotension and non-dipping are relatively common autonomic dysfunctions in patients with Parkinson disease (PD). These abnormalities have been thought to occur independently of striatal dopaminergic depletion; however, only little preliminary information is available. In this study, we investigated the association of neurocirculatory changes with striatal dopamine transporter status in 69 patients with early PD. Seventeen patients had orthostatic hypotension and 55 patients were non-dippers. A comparison between cases with and without orthostatic hypotension was insignificant for striatal dopamine transporter uptake. These insignificances continued in a comparison of dippers and non-dippers. These results suggest that sympathetic noradrenergic dysfunctions in PD are independent of striatal dopamine transporter depletion.",

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AU - You, Ie Ryung

AU - Yang, Dong Won

AU - Chung, Sung Woo

AU - Park, Jeong Wook

AU - Kim, Yeong In

AU - Lee, Kwang Soo

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N2 - Orthostatic hypotension and non-dipping are relatively common autonomic dysfunctions in patients with Parkinson disease (PD). These abnormalities have been thought to occur independently of striatal dopaminergic depletion; however, only little preliminary information is available. In this study, we investigated the association of neurocirculatory changes with striatal dopamine transporter status in 69 patients with early PD. Seventeen patients had orthostatic hypotension and 55 patients were non-dippers. A comparison between cases with and without orthostatic hypotension was insignificant for striatal dopamine transporter uptake. These insignificances continued in a comparison of dippers and non-dippers. These results suggest that sympathetic noradrenergic dysfunctions in PD are independent of striatal dopamine transporter depletion.

AB - Orthostatic hypotension and non-dipping are relatively common autonomic dysfunctions in patients with Parkinson disease (PD). These abnormalities have been thought to occur independently of striatal dopaminergic depletion; however, only little preliminary information is available. In this study, we investigated the association of neurocirculatory changes with striatal dopamine transporter status in 69 patients with early PD. Seventeen patients had orthostatic hypotension and 55 patients were non-dippers. A comparison between cases with and without orthostatic hypotension was insignificant for striatal dopamine transporter uptake. These insignificances continued in a comparison of dippers and non-dippers. These results suggest that sympathetic noradrenergic dysfunctions in PD are independent of striatal dopamine transporter depletion.

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Orthostatic hypotension, non-dipping and striatal dopamine in Parkinson disease

Abstract

Keywords

UN SDGs

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