Outcomes and disease activity during and after pregnancy in Asian women with MOGAD

Jae Won Hyun; De Cai Tian; Yun Xu; Naohiro Sakamoto; Shuhei Nishiyama; Tatsuro Misu; Dai Ichikawa; Ichiro Nakashima; Kazuo Fujihara; Lekha Pandit; Monalisa Vegda; Tianrong Yeo; Janis Siew Noi Tye; You Ri Kang; Tai Seung Nam; Woojun Kim; Kuo Hsuan Chang; Shanthi Viswanathan; Jyh Yung Hor; Hui Jieh Tan; Sasitorn Siritho; Dong Eun Lee; Na Young Park; Su Hyun Kim; Ho Jin Kim

doi:10.1177/13524585261424657

Outcomes and disease activity during and after pregnancy in Asian women with MOGAD

Jae Won Hyun
, De Cai Tian
, Yun Xu
, Naohiro Sakamoto
, Shuhei Nishiyama
, Tatsuro Misu
, Dai Ichikawa
, Ichiro Nakashima
, Kazuo Fujihara
, Lekha Pandit
, Monalisa Vegda
, Tianrong Yeo
, Janis Siew Noi Tye
, You Ri Kang
, Tai Seung Nam
, Woojun Kim
, Kuo Hsuan Chang
, Shanthi Viswanathan
, Jyh Yung Hor
, Hui Jieh Tan

Sasitorn Siritho, Dong Eun Lee, Na Young Park, Su Hyun Kim, Ho Jin Kim

National Cancer Center Korea
Capital Medical University
Tohoku University
Tohoku Medical and Pharmaceutical University
Southern Tohoku General Hospital
NITTE
Singapore Health Services
Chonnam National University
Chang Gung Memorial Hospital
Kuala Lumpur Hospital
Hospital Pulau Pinang
Kementerian Kesihatan Malaysia
Bumrungrad International Hospital

Research output: Contribution to journal › Article › peer-review

Abstract

This first international multicenter study evaluated pregnancy outcomes and their influence on disease activity in Asian women with myelin oligodendrocyte glycoprotein-antibody-associated disease (MOGAD) meeting the 2023 diagnostic criteria. Among 318 women with adult-onset MOGAD, 23 pregnancies after disease onset in 18 women were analyzed. Pregnancy outcomes were generally favorable, with most infants born healthy. Relapse rates decreased during pregnancy and returned postpartum. Three-quarters of women with previously monophasic disease transitioned to a relapsing course postpartum, although most attacks during and after pregnancy recovered well. These findings suggest that pregnancy can be considered with appropriate clinical monitoring in women with MOGAD.

Original language	English
Pages (from-to)	548-552
Number of pages	5
Journal	Multiple Sclerosis Journal
Volume	32
Issue number	5
DOIs	https://doi.org/10.1177/13524585261424657
State	Published - Apr 2026

Bibliographical note

Publisher Copyright:
© The Author(s), 2026

Keywords

Asia
MOG
Pregnancy

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10.1177/13524585261424657

Cite this

Hyun, J. W., Tian, D. C., Xu, Y., Sakamoto, N., Nishiyama, S., Misu, T., Ichikawa, D., Nakashima, I., Fujihara, K., Pandit, L., Vegda, M., Yeo, T., Tye, J. S. N., Kang, Y. R., Nam, T. S., Kim, W., Chang, K. H., Viswanathan, S., Hor, J. Y., ... Kim, H. J. (2026). Outcomes and disease activity during and after pregnancy in Asian women with MOGAD. Multiple Sclerosis Journal, 32(5), 548-552. https://doi.org/10.1177/13524585261424657

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title = "Outcomes and disease activity during and after pregnancy in Asian women with MOGAD",

abstract = "This first international multicenter study evaluated pregnancy outcomes and their influence on disease activity in Asian women with myelin oligodendrocyte glycoprotein-antibody-associated disease (MOGAD) meeting the 2023 diagnostic criteria. Among 318 women with adult-onset MOGAD, 23 pregnancies after disease onset in 18 women were analyzed. Pregnancy outcomes were generally favorable, with most infants born healthy. Relapse rates decreased during pregnancy and returned postpartum. Three-quarters of women with previously monophasic disease transitioned to a relapsing course postpartum, although most attacks during and after pregnancy recovered well. These findings suggest that pregnancy can be considered with appropriate clinical monitoring in women with MOGAD.",

keywords = "Asia, MOG, Pregnancy",

author = "Hyun, \{Jae Won\} and Tian, \{De Cai\} and Yun Xu and Naohiro Sakamoto and Shuhei Nishiyama and Tatsuro Misu and Dai Ichikawa and Ichiro Nakashima and Kazuo Fujihara and Lekha Pandit and Monalisa Vegda and Tianrong Yeo and Tye, \{Janis Siew Noi\} and Kang, \{You Ri\} and Nam, \{Tai Seung\} and Woojun Kim and Chang, \{Kuo Hsuan\} and Shanthi Viswanathan and Hor, \{Jyh Yung\} and Tan, \{Hui Jieh\} and Sasitorn Siritho and Lee, \{Dong Eun\} and Park, \{Na Young\} and Kim, \{Su Hyun\} and Kim, \{Ho Jin\}",

note = "Publisher Copyright: {\textcopyright} The Author(s), 2026",

year = "2026",

month = apr,

doi = "10.1177/13524585261424657",

language = "English",

volume = "32",

pages = "548--552",

journal = "Multiple Sclerosis Journal",

issn = "1352-4585",

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Hyun, JW, Tian, DC, Xu, Y, Sakamoto, N, Nishiyama, S, Misu, T, Ichikawa, D, Nakashima, I, Fujihara, K, Pandit, L, Vegda, M, Yeo, T, Tye, JSN, Kang, YR, Nam, TS, Kim, W, Chang, KH, Viswanathan, S, Hor, JY, Tan, HJ, Siritho, S, Lee, DE, Park, NY, Kim, SH & Kim, HJ 2026, 'Outcomes and disease activity during and after pregnancy in Asian women with MOGAD', Multiple Sclerosis Journal, vol. 32, no. 5, pp. 548-552. https://doi.org/10.1177/13524585261424657

TY - JOUR

T1 - Outcomes and disease activity during and after pregnancy in Asian women with MOGAD

AU - Hyun, Jae Won

AU - Tian, De Cai

AU - Xu, Yun

AU - Sakamoto, Naohiro

AU - Nishiyama, Shuhei

AU - Misu, Tatsuro

AU - Ichikawa, Dai

AU - Nakashima, Ichiro

AU - Fujihara, Kazuo

AU - Pandit, Lekha

AU - Vegda, Monalisa

AU - Yeo, Tianrong

AU - Tye, Janis Siew Noi

AU - Kang, You Ri

AU - Nam, Tai Seung

AU - Kim, Woojun

AU - Chang, Kuo Hsuan

AU - Viswanathan, Shanthi

AU - Hor, Jyh Yung

AU - Tan, Hui Jieh

AU - Siritho, Sasitorn

AU - Lee, Dong Eun

AU - Park, Na Young

AU - Kim, Su Hyun

AU - Kim, Ho Jin

PY - 2026/4

Y1 - 2026/4

N2 - This first international multicenter study evaluated pregnancy outcomes and their influence on disease activity in Asian women with myelin oligodendrocyte glycoprotein-antibody-associated disease (MOGAD) meeting the 2023 diagnostic criteria. Among 318 women with adult-onset MOGAD, 23 pregnancies after disease onset in 18 women were analyzed. Pregnancy outcomes were generally favorable, with most infants born healthy. Relapse rates decreased during pregnancy and returned postpartum. Three-quarters of women with previously monophasic disease transitioned to a relapsing course postpartum, although most attacks during and after pregnancy recovered well. These findings suggest that pregnancy can be considered with appropriate clinical monitoring in women with MOGAD.

AB - This first international multicenter study evaluated pregnancy outcomes and their influence on disease activity in Asian women with myelin oligodendrocyte glycoprotein-antibody-associated disease (MOGAD) meeting the 2023 diagnostic criteria. Among 318 women with adult-onset MOGAD, 23 pregnancies after disease onset in 18 women were analyzed. Pregnancy outcomes were generally favorable, with most infants born healthy. Relapse rates decreased during pregnancy and returned postpartum. Three-quarters of women with previously monophasic disease transitioned to a relapsing course postpartum, although most attacks during and after pregnancy recovered well. These findings suggest that pregnancy can be considered with appropriate clinical monitoring in women with MOGAD.

KW - Asia

KW - MOG

KW - Pregnancy

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SN - 1352-4585

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EP - 552

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

IS - 5

ER -

Outcomes and disease activity during and after pregnancy in Asian women with MOGAD

Abstract

Bibliographical note

Keywords

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