Abstract
Colorectal cancer (CRC) ranks third in cancer incidence and stands as the second leading cause of cancer-related deaths'globally. CRC tumorigenesis results from a cumulative set of genetic and epigenetic alterations, disrupting cancer-regulatory'processes like cell proliferation, metabolism, angiogenesis, cell death, invasion, and metastasis. Key epigenetic modifications'observed in cancers encompass abnormal DNA methylation, atypical histone modifications, and irregularities in noncoding'RNAs, such as microRNAs and long noncoding RNAs. The advancement in genomic technologies has positioned these genetic'and epigenetic shifts as potential clinical biomarkers for CRC patients. This review concisely covers the fundamental principles'of CRC-associated epigenetic changes, and examines in detail their emerging role as biomarkers for early detection, prognosis,'and treatment response prediction.
| Original language | English |
|---|---|
| Pages (from-to) | 131-151 |
| Number of pages | 21 |
| Journal | Intestinal Research |
| Volume | 22 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2024 |
Bibliographical note
Publisher Copyright:© (2024) Korean Association for the Study of Intestinal Diseases.
Keywords
- Biomarkers
- Colorectal neoplasms
- Diagnosis
- Epigenetic
- Prognosis
