Photo-Guided Sentinel Node Mapping in Breast Cancer Using Marker-Free Photo-Gamma Fusion Lymphoscintigraphy

Eun Seong Lee; In Kook Chun; Seunggyun Ha; Hai jeon Yoon; So Youn Jung; Seeyoun Lee; Seok Won Kim; Eun Sook Lee; Taeyoon Kim; Kwang Gi Kim; Byung Il Lee; Tae Sung Kim; Seok ki Kim

doi:10.1007/s13139-012-0170-8

Photo-Guided Sentinel Node Mapping in Breast Cancer Using Marker-Free Photo-Gamma Fusion Lymphoscintigraphy

Eun Seong Lee
, In Kook Chun
, Seunggyun Ha
, Hai jeon Yoon
, So Youn Jung
, Seeyoun Lee
, Seok Won Kim
, Eun Sook Lee
, Taeyoon Kim
, Kwang Gi Kim
, Byung Il Lee
, Tae Sung Kim
, Seok ki Kim

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: Photo-gamma fusion lymphoscintigraphy (PGFLS) was developed by overlying a conventional planar gamma image on a photograph for the guidance of sentinel node biopsy. The feasibility and accuracy of PGFLS was assessed in breast cancer patients. Methods: A digital camera and a gamma camera were coordinated to obtain photograph and gamma images from the same angle. Using the distance to the object and calibration acquisition with a flat phantom and radioactive markers, PGFLS was performed both in phantom and in patients without fiducial markers. Marker-free PGFLS was verified using flat phantom, anthropomorphic phantom with markers simulating sentinel nodes and breast cancer patients. In addition, the depth of the radioactive marker or sentinel node was calculated using two gamma images taken at right angles. The feasibility and accuracy of PGFLS were assessed in terms of mismatch errors of co-registration and depth with reference to the data from SPECT/CT. Results: The mismatch error was less than 6 mm in the flat phantom image at a distance from 50 to 62 cm without misalignment. In the anthropomorphic phantom study, co-registration error was 0. 42 ± 0. 29 cm; depth error was 0. 51 ± 0. 37 cm, which was well correlated with the reference value on SPECT/CT (x scale: R² = 0. 99, p < 0. 01; y scale: R² = 0. 99, p < 0. 01; depth: R² = 0. 99, p < 0. 01). In ten patients with breast cancer referred for lympho-SPECT/CT, PGFSL enabled photo-guided sentinel lymph node mapping with acceptable accuracy (co-registration error, 0. 47 ± 0. 24 cm; depth error, 1. 20 ±0. 41 cm). The results from PGFSL showed close correlation with those from SPECT/CT (x scale: R² = 0. 99, p < 0. 01; y scale: R² = 0. 98, p < 0. 01; depth: R² = 0. 77, p < 0. 01). Conclusions: The novel and convenient PGFLS technique is clinically feasible, showing acceptable accuracy and providing additional visual and quantitative information for sentinel lymph node mapping. This approach will facilitate photo-guided sentinel lymph node dissection in breast cancer.

Original language	English
Pages (from-to)	9-17
Number of pages	9
Journal	Nuclear Medicine and Molecular Imaging
Volume	47
Issue number	1
DOIs	https://doi.org/10.1007/s13139-012-0170-8
State	Published - Mar 2013

Bibliographical note

Funding Information:
This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MEST) (2012-0005987). The authors thank Mr. Jae Hoon Jung, Mr. Sang Hyuk Yoon, and Mr. Yun Chul Kim for their excellent technical and generous support.

Funding Information:
This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MEST) (2011–0019794).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Photo-gamma fusion lymphoscintigraphy
Sentinel lymph node

Access to Document

10.1007/s13139-012-0170-8

Cite this

@article{851129f1373b4b7f8eb1d182ce2c6900,

title = "Photo-Guided Sentinel Node Mapping in Breast Cancer Using Marker-Free Photo-Gamma Fusion Lymphoscintigraphy",

abstract = "Purpose: Photo-gamma fusion lymphoscintigraphy (PGFLS) was developed by overlying a conventional planar gamma image on a photograph for the guidance of sentinel node biopsy. The feasibility and accuracy of PGFLS was assessed in breast cancer patients. Methods: A digital camera and a gamma camera were coordinated to obtain photograph and gamma images from the same angle. Using the distance to the object and calibration acquisition with a flat phantom and radioactive markers, PGFLS was performed both in phantom and in patients without fiducial markers. Marker-free PGFLS was verified using flat phantom, anthropomorphic phantom with markers simulating sentinel nodes and breast cancer patients. In addition, the depth of the radioactive marker or sentinel node was calculated using two gamma images taken at right angles. The feasibility and accuracy of PGFLS were assessed in terms of mismatch errors of co-registration and depth with reference to the data from SPECT/CT. Results: The mismatch error was less than 6 mm in the flat phantom image at a distance from 50 to 62 cm without misalignment. In the anthropomorphic phantom study, co-registration error was 0. 42 ± 0. 29 cm; depth error was 0. 51 ± 0. 37 cm, which was well correlated with the reference value on SPECT/CT (x scale: R2 = 0. 99, p < 0. 01; y scale: R2 = 0. 99, p < 0. 01; depth: R2 = 0. 99, p < 0. 01). In ten patients with breast cancer referred for lympho-SPECT/CT, PGFSL enabled photo-guided sentinel lymph node mapping with acceptable accuracy (co-registration error, 0. 47 ± 0. 24 cm; depth error, 1. 20 ±0. 41 cm). The results from PGFSL showed close correlation with those from SPECT/CT (x scale: R2 = 0. 99, p < 0. 01; y scale: R2 = 0. 98, p < 0. 01; depth: R2 = 0. 77, p < 0. 01). Conclusions: The novel and convenient PGFLS technique is clinically feasible, showing acceptable accuracy and providing additional visual and quantitative information for sentinel lymph node mapping. This approach will facilitate photo-guided sentinel lymph node dissection in breast cancer.",

keywords = "Photo-gamma fusion lymphoscintigraphy, Sentinel lymph node",

author = "Lee, \{Eun Seong\} and Chun, \{In Kook\} and Seunggyun Ha and Yoon, \{Hai jeon\} and Jung, \{So Youn\} and Seeyoun Lee and Kim, \{Seok Won\} and Lee, \{Eun Sook\} and Taeyoon Kim and Kim, \{Kwang Gi\} and Lee, \{Byung Il\} and Kim, \{Tae Sung\} and Kim, \{Seok ki\}",

note = "Funding Information: This research was supported by the Bio \& Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MEST) (2012-0005987). The authors thank Mr. Jae Hoon Jung, Mr. Sang Hyuk Yoon, and Mr. Yun Chul Kim for their excellent technical and generous support. Funding Information: This research was supported by the Bio \& Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MEST) (2011–0019794). ",

year = "2013",

month = mar,

doi = "10.1007/s13139-012-0170-8",

language = "English",

volume = "47",

pages = "9--17",

journal = "Nuclear Medicine and Molecular Imaging",

issn = "1869-3474",

publisher = "Springer Verlag",

number = "1",

}

TY - JOUR

T1 - Photo-Guided Sentinel Node Mapping in Breast Cancer Using Marker-Free Photo-Gamma Fusion Lymphoscintigraphy

AU - Lee, Eun Seong

AU - Chun, In Kook

AU - Ha, Seunggyun

AU - Yoon, Hai jeon

AU - Jung, So Youn

AU - Lee, Seeyoun

AU - Kim, Seok Won

AU - Lee, Eun Sook

AU - Kim, Taeyoon

AU - Kim, Kwang Gi

AU - Lee, Byung Il

AU - Kim, Tae Sung

AU - Kim, Seok ki

N1 - Funding Information: This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MEST) (2012-0005987). The authors thank Mr. Jae Hoon Jung, Mr. Sang Hyuk Yoon, and Mr. Yun Chul Kim for their excellent technical and generous support. Funding Information: This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MEST) (2011–0019794).

PY - 2013/3

Y1 - 2013/3

N2 - Purpose: Photo-gamma fusion lymphoscintigraphy (PGFLS) was developed by overlying a conventional planar gamma image on a photograph for the guidance of sentinel node biopsy. The feasibility and accuracy of PGFLS was assessed in breast cancer patients. Methods: A digital camera and a gamma camera were coordinated to obtain photograph and gamma images from the same angle. Using the distance to the object and calibration acquisition with a flat phantom and radioactive markers, PGFLS was performed both in phantom and in patients without fiducial markers. Marker-free PGFLS was verified using flat phantom, anthropomorphic phantom with markers simulating sentinel nodes and breast cancer patients. In addition, the depth of the radioactive marker or sentinel node was calculated using two gamma images taken at right angles. The feasibility and accuracy of PGFLS were assessed in terms of mismatch errors of co-registration and depth with reference to the data from SPECT/CT. Results: The mismatch error was less than 6 mm in the flat phantom image at a distance from 50 to 62 cm without misalignment. In the anthropomorphic phantom study, co-registration error was 0. 42 ± 0. 29 cm; depth error was 0. 51 ± 0. 37 cm, which was well correlated with the reference value on SPECT/CT (x scale: R2 = 0. 99, p < 0. 01; y scale: R2 = 0. 99, p < 0. 01; depth: R2 = 0. 99, p < 0. 01). In ten patients with breast cancer referred for lympho-SPECT/CT, PGFSL enabled photo-guided sentinel lymph node mapping with acceptable accuracy (co-registration error, 0. 47 ± 0. 24 cm; depth error, 1. 20 ±0. 41 cm). The results from PGFSL showed close correlation with those from SPECT/CT (x scale: R2 = 0. 99, p < 0. 01; y scale: R2 = 0. 98, p < 0. 01; depth: R2 = 0. 77, p < 0. 01). Conclusions: The novel and convenient PGFLS technique is clinically feasible, showing acceptable accuracy and providing additional visual and quantitative information for sentinel lymph node mapping. This approach will facilitate photo-guided sentinel lymph node dissection in breast cancer.

AB - Purpose: Photo-gamma fusion lymphoscintigraphy (PGFLS) was developed by overlying a conventional planar gamma image on a photograph for the guidance of sentinel node biopsy. The feasibility and accuracy of PGFLS was assessed in breast cancer patients. Methods: A digital camera and a gamma camera were coordinated to obtain photograph and gamma images from the same angle. Using the distance to the object and calibration acquisition with a flat phantom and radioactive markers, PGFLS was performed both in phantom and in patients without fiducial markers. Marker-free PGFLS was verified using flat phantom, anthropomorphic phantom with markers simulating sentinel nodes and breast cancer patients. In addition, the depth of the radioactive marker or sentinel node was calculated using two gamma images taken at right angles. The feasibility and accuracy of PGFLS were assessed in terms of mismatch errors of co-registration and depth with reference to the data from SPECT/CT. Results: The mismatch error was less than 6 mm in the flat phantom image at a distance from 50 to 62 cm without misalignment. In the anthropomorphic phantom study, co-registration error was 0. 42 ± 0. 29 cm; depth error was 0. 51 ± 0. 37 cm, which was well correlated with the reference value on SPECT/CT (x scale: R2 = 0. 99, p < 0. 01; y scale: R2 = 0. 99, p < 0. 01; depth: R2 = 0. 99, p < 0. 01). In ten patients with breast cancer referred for lympho-SPECT/CT, PGFSL enabled photo-guided sentinel lymph node mapping with acceptable accuracy (co-registration error, 0. 47 ± 0. 24 cm; depth error, 1. 20 ±0. 41 cm). The results from PGFSL showed close correlation with those from SPECT/CT (x scale: R2 = 0. 99, p < 0. 01; y scale: R2 = 0. 98, p < 0. 01; depth: R2 = 0. 77, p < 0. 01). Conclusions: The novel and convenient PGFLS technique is clinically feasible, showing acceptable accuracy and providing additional visual and quantitative information for sentinel lymph node mapping. This approach will facilitate photo-guided sentinel lymph node dissection in breast cancer.

KW - Photo-gamma fusion lymphoscintigraphy

KW - Sentinel lymph node

UR - https://www.scopus.com/pages/publications/84874219050

U2 - 10.1007/s13139-012-0170-8

DO - 10.1007/s13139-012-0170-8

M3 - Article

AN - SCOPUS:84874219050

SN - 1869-3474

VL - 47

SP - 9

EP - 17

JO - Nuclear Medicine and Molecular Imaging

JF - Nuclear Medicine and Molecular Imaging

IS - 1

ER -

Photo-Guided Sentinel Node Mapping in Breast Cancer Using Marker-Free Photo-Gamma Fusion Lymphoscintigraphy

Abstract

Bibliographical note

UN SDGs

Keywords

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