Poly(ethylene glycol)-crosslinked fullerenes for high efficient phototherapy

Dong Jin Lee; Yong Sik Ahn; Yu Seok Youn; Eun Seong Lee

doi:10.1002/pat.3074

Poly(ethylene glycol)-crosslinked fullerenes for high efficient phototherapy

Dong Jin Lee
, Yong Sik Ahn
, Yu Seok Youn
, Eun Seong Lee

Department of Biomedical-Chemical Engineering

The Catholic University of Korea
Sungkyunkwan University

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Poly(ethylene glycol)-crosslinked multimeric C₆₀ was developed for use in photothermal/photodynamic therapy of malignant cells. We showed that: (i) the tumor surface temperature on KB tumor-bearing nude mice treated with multimeric C₆₀ reached about 44°C; (ii) this hyperthermic condition and tremendous singlet oxygen generation from multimeric C₆₀ resulted in significant tumor volume regression in KB tumor-bearing nude mice; and (iii) multimeric C₆₀ also efficiently inhibited arthritic progress in the arthritis-induced DBA/1J mice model. This multimeric C₆₀ may be useful for photothermal/photodynamic cell ablation in various malignant cells.

Original language	English
Pages (from-to)	220-227
Number of pages	8
Journal	Polymers for Advanced Technologies
Volume	24
Issue number	2
DOIs	https://doi.org/10.1002/pat.3074
State	Published - Feb 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer therapy
Multimeric fullerene
Photodynamic
Photothermal
Rheumatoid arthritis therapy

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10.1002/pat.3074

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title = "Poly(ethylene glycol)-crosslinked fullerenes for high efficient phototherapy",

abstract = "Poly(ethylene glycol)-crosslinked multimeric C60 was developed for use in photothermal/photodynamic therapy of malignant cells. We showed that: (i) the tumor surface temperature on KB tumor-bearing nude mice treated with multimeric C60 reached about 44°C; (ii) this hyperthermic condition and tremendous singlet oxygen generation from multimeric C60 resulted in significant tumor volume regression in KB tumor-bearing nude mice; and (iii) multimeric C60 also efficiently inhibited arthritic progress in the arthritis-induced DBA/1J mice model. This multimeric C60 may be useful for photothermal/photodynamic cell ablation in various malignant cells.",

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AU - Lee, Dong Jin

AU - Ahn, Yong Sik

AU - Youn, Yu Seok

AU - Lee, Eun Seong

PY - 2013/2

Y1 - 2013/2

N2 - Poly(ethylene glycol)-crosslinked multimeric C60 was developed for use in photothermal/photodynamic therapy of malignant cells. We showed that: (i) the tumor surface temperature on KB tumor-bearing nude mice treated with multimeric C60 reached about 44°C; (ii) this hyperthermic condition and tremendous singlet oxygen generation from multimeric C60 resulted in significant tumor volume regression in KB tumor-bearing nude mice; and (iii) multimeric C60 also efficiently inhibited arthritic progress in the arthritis-induced DBA/1J mice model. This multimeric C60 may be useful for photothermal/photodynamic cell ablation in various malignant cells.

AB - Poly(ethylene glycol)-crosslinked multimeric C60 was developed for use in photothermal/photodynamic therapy of malignant cells. We showed that: (i) the tumor surface temperature on KB tumor-bearing nude mice treated with multimeric C60 reached about 44°C; (ii) this hyperthermic condition and tremendous singlet oxygen generation from multimeric C60 resulted in significant tumor volume regression in KB tumor-bearing nude mice; and (iii) multimeric C60 also efficiently inhibited arthritic progress in the arthritis-induced DBA/1J mice model. This multimeric C60 may be useful for photothermal/photodynamic cell ablation in various malignant cells.

KW - Cancer therapy

KW - Multimeric fullerene

KW - Photodynamic

KW - Photothermal

KW - Rheumatoid arthritis therapy

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SN - 1042-7147

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JO - Polymers for Advanced Technologies

JF - Polymers for Advanced Technologies

IS - 2

ER -

Poly(ethylene glycol)-crosslinked fullerenes for high efficient phototherapy

Abstract

UN SDGs

Keywords

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