Poly(ethylene oxide sulfide): New poly(ethylene glycol) derivatives degradable in reductive conditions

Yan Lee; Heebeom Koo; Geun Woo Jin; Heejung Mo; Min Yi Cho; Jong Yeun Park; Joon Sig Choi; Jong Sang Park

doi:10.1021/bm049658l

Poly(ethylene oxide sulfide): New poly(ethylene glycol) derivatives degradable in reductive conditions

Yan Lee
, Heebeom Koo
, Geun Woo Jin
, Heejung Mo
, Min Yi Cho
, Jong Yeun Park
, Joon Sig Choi
, Jong Sang Park

Department of Biomedicine & Health Science

Seoul National University
Chungnam National University

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Abstract

Poly(ethylene oxide sulfide) (PEOS), polymers consisting of an internal ethylene oxide oligomer and disulfide linkage, were synthesized and characterized. The degree of polymerization was dependent upon temperature, dimethyl sulfoxide condition, and monomer hydrophobicity. The stability of PEOS was measured by the size exclusion chromatography method after the incubation both with and without 5 mM glutathione. The disulfide bond was stable in the extracellular condition but completely degraded in 2 h in the reductive cytosolic condition. Hydrophilic PEOS polymers showed no cytotoxicity on the HepG2 cell line. On the basis of these properties, PEOS can be applied in many drug delivery fields.

Original language	English
Pages (from-to)	24-26
Number of pages	3
Journal	Biomacromolecules
Volume	6
Issue number	1
DOIs	https://doi.org/10.1021/bm049658l
State	Published - Jan 2005

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title = "Poly(ethylene oxide sulfide): New poly(ethylene glycol) derivatives degradable in reductive conditions",

abstract = "Poly(ethylene oxide sulfide) (PEOS), polymers consisting of an internal ethylene oxide oligomer and disulfide linkage, were synthesized and characterized. The degree of polymerization was dependent upon temperature, dimethyl sulfoxide condition, and monomer hydrophobicity. The stability of PEOS was measured by the size exclusion chromatography method after the incubation both with and without 5 mM glutathione. The disulfide bond was stable in the extracellular condition but completely degraded in 2 h in the reductive cytosolic condition. Hydrophilic PEOS polymers showed no cytotoxicity on the HepG2 cell line. On the basis of these properties, PEOS can be applied in many drug delivery fields.",

author = "Yan Lee and Heebeom Koo and Jin, \{Geun Woo\} and Heejung Mo and Cho, \{Min Yi\} and Park, \{Jong Yeun\} and Choi, \{Joon Sig\} and Park, \{Jong Sang\}",

year = "2005",

month = jan,

doi = "10.1021/bm049658l",

language = "English",

volume = "6",

pages = "24--26",

journal = "Biomacromolecules",

issn = "1525-7797",

publisher = "American Chemical Society",

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T1 - Poly(ethylene oxide sulfide)

T2 - New poly(ethylene glycol) derivatives degradable in reductive conditions

AU - Lee, Yan

AU - Koo, Heebeom

AU - Jin, Geun Woo

AU - Mo, Heejung

AU - Cho, Min Yi

AU - Park, Jong Yeun

AU - Choi, Joon Sig

AU - Park, Jong Sang

PY - 2005/1

Y1 - 2005/1

N2 - Poly(ethylene oxide sulfide) (PEOS), polymers consisting of an internal ethylene oxide oligomer and disulfide linkage, were synthesized and characterized. The degree of polymerization was dependent upon temperature, dimethyl sulfoxide condition, and monomer hydrophobicity. The stability of PEOS was measured by the size exclusion chromatography method after the incubation both with and without 5 mM glutathione. The disulfide bond was stable in the extracellular condition but completely degraded in 2 h in the reductive cytosolic condition. Hydrophilic PEOS polymers showed no cytotoxicity on the HepG2 cell line. On the basis of these properties, PEOS can be applied in many drug delivery fields.

AB - Poly(ethylene oxide sulfide) (PEOS), polymers consisting of an internal ethylene oxide oligomer and disulfide linkage, were synthesized and characterized. The degree of polymerization was dependent upon temperature, dimethyl sulfoxide condition, and monomer hydrophobicity. The stability of PEOS was measured by the size exclusion chromatography method after the incubation both with and without 5 mM glutathione. The disulfide bond was stable in the extracellular condition but completely degraded in 2 h in the reductive cytosolic condition. Hydrophilic PEOS polymers showed no cytotoxicity on the HepG2 cell line. On the basis of these properties, PEOS can be applied in many drug delivery fields.

UR - https://www.scopus.com/pages/publications/14044274143

U2 - 10.1021/bm049658l

DO - 10.1021/bm049658l

M3 - Article

C2 - 15638498

AN - SCOPUS:14044274143

SN - 1525-7797

VL - 6

SP - 24

EP - 26

JO - Biomacromolecules

JF - Biomacromolecules

IS - 1

ER -

Poly(ethylene oxide sulfide): New poly(ethylene glycol) derivatives degradable in reductive conditions

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