Polymer-caged lipsomes: A pH-responsive delivery system with high stability

Sang Min Lee; Haimei Chen; Christine M. Dettmer; Thomas V. O'Halloran; Sonbinh T. Nguyen

doi:10.1021/ja070748i

Polymer-caged lipsomes: A pH-responsive delivery system with high stability

Sang Min Lee, Haimei Chen, Christine M. Dettmer, Thomas V. O'Halloran, Sonbinh T. Nguyen

Northwestern University

Research output: Contribution to journal › Article › peer-review

224 Scopus citations

Abstract

Polymer-incorporated liposomes were prepared from preformed liposomes and a cholesterol-functionalized poly(acrylic acid) additive via a simple drop-in procedure. These modified liposomes possess surface-active carboxylate groups that can be cross-linked with telechelic 2,2′-(ethylenedioxy)bis(ethylamine) linkers, resulting in polymer-caged liposomes (PCLs) that are highly stable and have tunable pH-sensitive responses.

Original language	English
Pages (from-to)	15096-15097
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	129
Issue number	49
DOIs	https://doi.org/10.1021/ja070748i
State	Published - 12 Dec 2007

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abstract = "Polymer-incorporated liposomes were prepared from preformed liposomes and a cholesterol-functionalized poly(acrylic acid) additive via a simple drop-in procedure. These modified liposomes possess surface-active carboxylate groups that can be cross-linked with telechelic 2,2′-(ethylenedioxy)bis(ethylamine) linkers, resulting in polymer-caged liposomes (PCLs) that are highly stable and have tunable pH-sensitive responses.",

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AU - Chen, Haimei

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AU - Nguyen, Sonbinh T.

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AB - Polymer-incorporated liposomes were prepared from preformed liposomes and a cholesterol-functionalized poly(acrylic acid) additive via a simple drop-in procedure. These modified liposomes possess surface-active carboxylate groups that can be cross-linked with telechelic 2,2′-(ethylenedioxy)bis(ethylamine) linkers, resulting in polymer-caged liposomes (PCLs) that are highly stable and have tunable pH-sensitive responses.

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Polymer-caged lipsomes: A pH-responsive delivery system with high stability

Abstract

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