Polymer-caged lipsomes: A pH-responsive delivery system with high stability

Sang Min Lee; Haimei Chen; Christine M. Dettmer; Thomas V. O'Halloran; Sonbinh T. Nguyen

doi:10.1021/ja070748i

Polymer-caged lipsomes: A pH-responsive delivery system with high stability

Sang Min Lee
, Haimei Chen
, Christine M. Dettmer
, Thomas V. O'Halloran
, Sonbinh T. Nguyen

Northwestern University

Research output: Contribution to journal › Article › peer-review

237 Scopus citations

Abstract

Polymer-incorporated liposomes were prepared from preformed liposomes and a cholesterol-functionalized poly(acrylic acid) additive via a simple drop-in procedure. These modified liposomes possess surface-active carboxylate groups that can be cross-linked with telechelic 2,2′-(ethylenedioxy)bis(ethylamine) linkers, resulting in polymer-caged liposomes (PCLs) that are highly stable and have tunable pH-sensitive responses.

Original language	English
Pages (from-to)	15096-15097
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	129
Issue number	49
DOIs	https://doi.org/10.1021/ja070748i
State	Published - 12 Dec 2007

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10.1021/ja070748i

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title = "Polymer-caged lipsomes: A pH-responsive delivery system with high stability",

abstract = "Polymer-incorporated liposomes were prepared from preformed liposomes and a cholesterol-functionalized poly(acrylic acid) additive via a simple drop-in procedure. These modified liposomes possess surface-active carboxylate groups that can be cross-linked with telechelic 2,2′-(ethylenedioxy)bis(ethylamine) linkers, resulting in polymer-caged liposomes (PCLs) that are highly stable and have tunable pH-sensitive responses.",

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T1 - Polymer-caged lipsomes

T2 - A pH-responsive delivery system with high stability

AU - Lee, Sang Min

AU - Chen, Haimei

AU - Dettmer, Christine M.

AU - O'Halloran, Thomas V.

AU - Nguyen, Sonbinh T.

PY - 2007/12/12

Y1 - 2007/12/12

N2 - Polymer-incorporated liposomes were prepared from preformed liposomes and a cholesterol-functionalized poly(acrylic acid) additive via a simple drop-in procedure. These modified liposomes possess surface-active carboxylate groups that can be cross-linked with telechelic 2,2′-(ethylenedioxy)bis(ethylamine) linkers, resulting in polymer-caged liposomes (PCLs) that are highly stable and have tunable pH-sensitive responses.

AB - Polymer-incorporated liposomes were prepared from preformed liposomes and a cholesterol-functionalized poly(acrylic acid) additive via a simple drop-in procedure. These modified liposomes possess surface-active carboxylate groups that can be cross-linked with telechelic 2,2′-(ethylenedioxy)bis(ethylamine) linkers, resulting in polymer-caged liposomes (PCLs) that are highly stable and have tunable pH-sensitive responses.

UR - https://www.scopus.com/pages/publications/37049010752

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DO - 10.1021/ja070748i

M3 - Article

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IS - 49

ER -

Polymer-caged lipsomes: A pH-responsive delivery system with high stability

Abstract

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