Abstract
To deliver nucleic acids including plasmid DNA (pDNA) and short interfering RNA (siRNA), polymeric gene carriers equipped with various functionalities have been extensively investigated. The functionalities of these polymeric vectors have been designed to overcome various extracellular and intracellular hurdles that nucleic acids and their carriers encounter during their journey from injection site to intracellular target site. This review briefly introduces known extracellular and intracellular issues of nucleic acid delivery and their solution strategies. We examine significant yet overlooked factors affecting nucleic acid delivery (e.g., microenvironmental pH, polymer/siRNA complexation, and pharmaceutical formulation) and highlight our reported approaches to solve these problems.
| Original language | English |
|---|---|
| Pages (from-to) | 256-264 |
| Number of pages | 9 |
| Journal | Journal of Controlled Release |
| Volume | 164 |
| Issue number | 3 |
| DOIs | |
| State | Published - 28 Dec 2012 |
Bibliographical note
Funding Information:This work was supported by NIH GM82866 (Y.H. Bae), Basic Science Research Program through National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( 2012R1A1A1014718 , H.C. Kang), and Research Fund of The Catholic University of Korea ( M-2011-B0014-00002 , H.C. Kang).
Keywords
- Gene delivery
- Non-viral gene delivery
- Nucleic acid delivery
- Plasmid DNA
- Polymeric gene delivery
- Short interfering RNA
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