Polymorphism of CTLA-4 gene at position 49 of exon 1 may be associated with schizophrenia in the Korean population

Tae Youn Jun; Chi Un Pae; Jeong Ho Chae; Won Myong Bahk; Kwang Soo Kim; Hoon Han

doi:10.1016/S0165-1781(02)00031-8

Polymorphism of CTLA-4 gene at position 49 of exon 1 may be associated with schizophrenia in the Korean population

Tae Youn Jun
, Chi Un Pae
, Jeong Ho Chae
, Won Myong Bahk
, Kwang Soo Kim
, Hoon Han

Department of Psychiatry

The Catholic University of Korea

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

This study was carried out to investigate the association of a polymorphism of the CTLA-4 gene, at position 49 of exon 1, with schizophrenia in the Korean population. Among Korean patients diagnosed with schizophrenia according to DSM-IV, 116 patients who met the selection criteria were recruited for the study. One hundred and forty-nine normal healthy Koreans from the Catholic Hemopoietic Stem Cell Information Bank, were used as a normal control group. DNA was extracted from whole blood using proteinase K and the CTLA-4 gene region was amplified by polymerase chain reaction. Geneo typing was performed by single strand conformation polymorphism (SSCP). The genotype and allele distribution in patients with schizophrenia was significantly different from that seen in the control group. This study suggests a putative role of the CTLA-4 gene polymorphism at position 49 of exon 1 for schizophrenia in the Korean population, although the detailed mechanisms remained to be elucidated.

Original language	English
Pages (from-to)	19-25
Number of pages	7
Journal	Psychiatry Research
Volume	110
Issue number	1
DOIs	https://doi.org/10.1016/S0165-1781(02)00031-8
State	Published - 15 May 2002

Bibliographical note

Funding Information:
This study was supported by a grant from the Korea Health 21 R&D Project (HMP-00-GN-01-0002), Ministry of Health and Welfare, Republic of Korea. The authors express heartfelt thanks to Drs H. Flinstad Harbo, Institute of Transplantation Immunology, National Hospital, Oslo, Norway, and Alessandro Serretti, Department of Psychiatry, Vita-Salute University, San Raffaele Institute, Milan, Italy, for their helpful suggestions. We also thank Young-Mi Park and Hee-Ohk Kim for their technical support.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Association study
CTLA-4 gene polymorphism
Schizophrenia

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10.1016/S0165-1781(02)00031-8

Cite this

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title = "Polymorphism of CTLA-4 gene at position 49 of exon 1 may be associated with schizophrenia in the Korean population",

abstract = "This study was carried out to investigate the association of a polymorphism of the CTLA-4 gene, at position 49 of exon 1, with schizophrenia in the Korean population. Among Korean patients diagnosed with schizophrenia according to DSM-IV, 116 patients who met the selection criteria were recruited for the study. One hundred and forty-nine normal healthy Koreans from the Catholic Hemopoietic Stem Cell Information Bank, were used as a normal control group. DNA was extracted from whole blood using proteinase K and the CTLA-4 gene region was amplified by polymerase chain reaction. Geneo typing was performed by single strand conformation polymorphism (SSCP). The genotype and allele distribution in patients with schizophrenia was significantly different from that seen in the control group. This study suggests a putative role of the CTLA-4 gene polymorphism at position 49 of exon 1 for schizophrenia in the Korean population, although the detailed mechanisms remained to be elucidated.",

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note = "Funding Information: This study was supported by a grant from the Korea Health 21 R\&D Project (HMP-00-GN-01-0002), Ministry of Health and Welfare, Republic of Korea. The authors express heartfelt thanks to Drs H. Flinstad Harbo, Institute of Transplantation Immunology, National Hospital, Oslo, Norway, and Alessandro Serretti, Department of Psychiatry, Vita-Salute University, San Raffaele Institute, Milan, Italy, for their helpful suggestions. We also thank Young-Mi Park and Hee-Ohk Kim for their technical support.",

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AU - Bahk, Won Myong

AU - Kim, Kwang Soo

AU - Han, Hoon

N1 - Funding Information: This study was supported by a grant from the Korea Health 21 R&D Project (HMP-00-GN-01-0002), Ministry of Health and Welfare, Republic of Korea. The authors express heartfelt thanks to Drs H. Flinstad Harbo, Institute of Transplantation Immunology, National Hospital, Oslo, Norway, and Alessandro Serretti, Department of Psychiatry, Vita-Salute University, San Raffaele Institute, Milan, Italy, for their helpful suggestions. We also thank Young-Mi Park and Hee-Ohk Kim for their technical support.

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N2 - This study was carried out to investigate the association of a polymorphism of the CTLA-4 gene, at position 49 of exon 1, with schizophrenia in the Korean population. Among Korean patients diagnosed with schizophrenia according to DSM-IV, 116 patients who met the selection criteria were recruited for the study. One hundred and forty-nine normal healthy Koreans from the Catholic Hemopoietic Stem Cell Information Bank, were used as a normal control group. DNA was extracted from whole blood using proteinase K and the CTLA-4 gene region was amplified by polymerase chain reaction. Geneo typing was performed by single strand conformation polymorphism (SSCP). The genotype and allele distribution in patients with schizophrenia was significantly different from that seen in the control group. This study suggests a putative role of the CTLA-4 gene polymorphism at position 49 of exon 1 for schizophrenia in the Korean population, although the detailed mechanisms remained to be elucidated.

AB - This study was carried out to investigate the association of a polymorphism of the CTLA-4 gene, at position 49 of exon 1, with schizophrenia in the Korean population. Among Korean patients diagnosed with schizophrenia according to DSM-IV, 116 patients who met the selection criteria were recruited for the study. One hundred and forty-nine normal healthy Koreans from the Catholic Hemopoietic Stem Cell Information Bank, were used as a normal control group. DNA was extracted from whole blood using proteinase K and the CTLA-4 gene region was amplified by polymerase chain reaction. Geneo typing was performed by single strand conformation polymorphism (SSCP). The genotype and allele distribution in patients with schizophrenia was significantly different from that seen in the control group. This study suggests a putative role of the CTLA-4 gene polymorphism at position 49 of exon 1 for schizophrenia in the Korean population, although the detailed mechanisms remained to be elucidated.

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KW - Schizophrenia

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SN - 0165-1781

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JF - Psychiatry Research

IS - 1

ER -

Polymorphism of CTLA-4 gene at position 49 of exon 1 may be associated with schizophrenia in the Korean population

Abstract

Bibliographical note

UN SDGs

Keywords

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