Polymorphism of the serotonin transporter gene and symptomatic dimensions of schizophrenia in the Korean population

Chi Un Pae; Jung Jin Kim; Soo Jung Lee; Chang Uk Lee; Chul Lee; In Ho Paik; Ho Ran Park; Soo Yang; Alessandro Serretti

doi:10.1159/000071212

Polymorphism of the serotonin transporter gene and symptomatic dimensions of schizophrenia in the Korean population

Chi Un Pae, Jung Jin Kim, Soo Jung Lee, Chang Uk Lee, Chul Lee, In Ho Paik, Ho Ran Park, Soo Yang, Alessandro Serretti

Department of Psychiatry

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

This study was aimed to test the association between schizophrenia and a functional serotonin polymorphism (5-HTTLPR) in the upstream regulatory region. Genomic DNA analysis with polymerase chain reaction was used for 5-HTTLPR genotyping. One hundred and eleven patients with schizophrenia and 208 healthy individuals participated in this study. There were significant differences in the negative score and general psychopathology score of the positive and negative syndrome scale according to 5-HTTLPR genotypes and alleles, although no significant differences in allele or genotype frequencies between the two groups were found. These results suggest that 5-HTTLPR may contribute to the susceptibility to the symptomatology of schizophrenia but not to the development of the disorder itself, at least in the Korean population.

Original language	English
Pages (from-to)	182-186
Number of pages	5
Journal	Neuropsychobiology
Volume	47
Issue number	4
DOIs	https://doi.org/10.1159/000071212
State	Published - 2003

Keywords

Korean population
Schizophrenia
Serotonin transporter gene polymorphism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000071212

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abstract = "This study was aimed to test the association between schizophrenia and a functional serotonin polymorphism (5-HTTLPR) in the upstream regulatory region. Genomic DNA analysis with polymerase chain reaction was used for 5-HTTLPR genotyping. One hundred and eleven patients with schizophrenia and 208 healthy individuals participated in this study. There were significant differences in the negative score and general psychopathology score of the positive and negative syndrome scale according to 5-HTTLPR genotypes and alleles, although no significant differences in allele or genotype frequencies between the two groups were found. These results suggest that 5-HTTLPR may contribute to the susceptibility to the symptomatology of schizophrenia but not to the development of the disorder itself, at least in the Korean population.",

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AU - Pae, Chi Un

AU - Kim, Jung Jin

AU - Lee, Soo Jung

AU - Lee, Chang Uk

AU - Lee, Chul

AU - Paik, In Ho

AU - Park, Ho Ran

AU - Yang, Soo

AU - Serretti, Alessandro

PY - 2003

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AB - This study was aimed to test the association between schizophrenia and a functional serotonin polymorphism (5-HTTLPR) in the upstream regulatory region. Genomic DNA analysis with polymerase chain reaction was used for 5-HTTLPR genotyping. One hundred and eleven patients with schizophrenia and 208 healthy individuals participated in this study. There were significant differences in the negative score and general psychopathology score of the positive and negative syndrome scale according to 5-HTTLPR genotypes and alleles, although no significant differences in allele or genotype frequencies between the two groups were found. These results suggest that 5-HTTLPR may contribute to the susceptibility to the symptomatology of schizophrenia but not to the development of the disorder itself, at least in the Korean population.

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Polymorphism of the serotonin transporter gene and symptomatic dimensions of schizophrenia in the Korean population

Abstract

Keywords

UN SDGs

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