Predictive value of ipsilateral central lymph node metastasis for contralateral central lymph node metastasis in patients with thyroid cancer: Systematic review and meta-analysis

Do Hyun Kim; Geun Jeon Kim; Sung Won Kim; Se Hwan Hwang

doi:10.1002/hed.26787

Predictive value of ipsilateral central lymph node metastasis for contralateral central lymph node metastasis in patients with thyroid cancer: Systematic review and meta-analysis

Do Hyun Kim, Geun Jeon Kim, Sung Won Kim, Se Hwan Hwang

Catholic Univ. of Korea Coll. Med.

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Careful consideration of prophylactic central compartment dissection is required to ensure that its benefits outweigh its risks in the thyroid cancer. Sixteen prospective or retrospective studies were included. True positive, true negative, false positive, and false negative were extracted from each study. The diagnostic odds ratio of ipsilateral central lymph node metastasis (iCLNM) for predicting contralateral central lymph node metastasis (cCLNM) was 12.9237 (95% confidence interval [CI], 8.1595–20.4695). The area under the summary receiver operating characteristic curve was 0.854. The sensitivity, specificity, and negative predictive value were 0.8925 [0.8232–0.9368], 0.6884 [0.6311–0.7404], and 0.9802 [0.9631–0.9894], respectively. There were strong correlations between cCLNM and clinicopathologic characteristics. Ipsilateral central lymph node pathology is useful for predicting contralateral central compartment invasion in patients with thyroid cancer. In addition, clinicopathologic characteristics were associated with cCLNM in patients with unilateral thyroid cancer.

Original language	English
Pages (from-to)	3177-3184
Number of pages	8
Journal	Head and Neck
Volume	43
Issue number	10
DOIs	https://doi.org/10.1002/hed.26787
State	Published - Oct 2021

Bibliographical note

Funding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2020R1I1A1A01051844, 2018R1D1A1B07045421) and the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science & ICT (2018M3A9E8020856, 2019M3A9H2032424, 2019M3E5D5064110). The sponsors had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Funding Information:
National Research Foundation of Korea, Grant/Award Numbers: 2018M3A9E8020856, 2018R1D1A1B07045421, 2019M3A9H2032424, 2019M3E5D5064110, 2020R1I1A1A01051844 Funding information

Publisher Copyright:
© 2021 Wiley Periodicals LLC.

Keywords

lymphatic metastasis
neck
predictive value of tests
prognosis
thyroid neoplasm

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hed.26787

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title = "Predictive value of ipsilateral central lymph node metastasis for contralateral central lymph node metastasis in patients with thyroid cancer: Systematic review and meta-analysis",

abstract = "Careful consideration of prophylactic central compartment dissection is required to ensure that its benefits outweigh its risks in the thyroid cancer. Sixteen prospective or retrospective studies were included. True positive, true negative, false positive, and false negative were extracted from each study. The diagnostic odds ratio of ipsilateral central lymph node metastasis (iCLNM) for predicting contralateral central lymph node metastasis (cCLNM) was 12.9237 (95% confidence interval [CI], 8.1595–20.4695). The area under the summary receiver operating characteristic curve was 0.854. The sensitivity, specificity, and negative predictive value were 0.8925 [0.8232–0.9368], 0.6884 [0.6311–0.7404], and 0.9802 [0.9631–0.9894], respectively. There were strong correlations between cCLNM and clinicopathologic characteristics. Ipsilateral central lymph node pathology is useful for predicting contralateral central compartment invasion in patients with thyroid cancer. In addition, clinicopathologic characteristics were associated with cCLNM in patients with unilateral thyroid cancer.",

keywords = "lymphatic metastasis, neck, predictive value of tests, prognosis, thyroid neoplasm",

author = "Kim, {Do Hyun} and Kim, {Geun Jeon} and Kim, {Sung Won} and Hwang, {Se Hwan}",

note = "Funding Information: This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2020R1I1A1A01051844, 2018R1D1A1B07045421) and the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science & ICT (2018M3A9E8020856, 2019M3A9H2032424, 2019M3E5D5064110). The sponsors had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Funding Information: National Research Foundation of Korea, Grant/Award Numbers: 2018M3A9E8020856, 2018R1D1A1B07045421, 2019M3A9H2032424, 2019M3E5D5064110, 2020R1I1A1A01051844 Funding information Publisher Copyright: {\textcopyright} 2021 Wiley Periodicals LLC.",

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AU - Kim, Do Hyun

AU - Kim, Geun Jeon

AU - Kim, Sung Won

AU - Hwang, Se Hwan

N1 - Funding Information: This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2020R1I1A1A01051844, 2018R1D1A1B07045421) and the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science & ICT (2018M3A9E8020856, 2019M3A9H2032424, 2019M3E5D5064110). The sponsors had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Funding Information: National Research Foundation of Korea, Grant/Award Numbers: 2018M3A9E8020856, 2018R1D1A1B07045421, 2019M3A9H2032424, 2019M3E5D5064110, 2020R1I1A1A01051844 Funding information Publisher Copyright: © 2021 Wiley Periodicals LLC.

PY - 2021/10

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N2 - Careful consideration of prophylactic central compartment dissection is required to ensure that its benefits outweigh its risks in the thyroid cancer. Sixteen prospective or retrospective studies were included. True positive, true negative, false positive, and false negative were extracted from each study. The diagnostic odds ratio of ipsilateral central lymph node metastasis (iCLNM) for predicting contralateral central lymph node metastasis (cCLNM) was 12.9237 (95% confidence interval [CI], 8.1595–20.4695). The area under the summary receiver operating characteristic curve was 0.854. The sensitivity, specificity, and negative predictive value were 0.8925 [0.8232–0.9368], 0.6884 [0.6311–0.7404], and 0.9802 [0.9631–0.9894], respectively. There were strong correlations between cCLNM and clinicopathologic characteristics. Ipsilateral central lymph node pathology is useful for predicting contralateral central compartment invasion in patients with thyroid cancer. In addition, clinicopathologic characteristics were associated with cCLNM in patients with unilateral thyroid cancer.

AB - Careful consideration of prophylactic central compartment dissection is required to ensure that its benefits outweigh its risks in the thyroid cancer. Sixteen prospective or retrospective studies were included. True positive, true negative, false positive, and false negative were extracted from each study. The diagnostic odds ratio of ipsilateral central lymph node metastasis (iCLNM) for predicting contralateral central lymph node metastasis (cCLNM) was 12.9237 (95% confidence interval [CI], 8.1595–20.4695). The area under the summary receiver operating characteristic curve was 0.854. The sensitivity, specificity, and negative predictive value were 0.8925 [0.8232–0.9368], 0.6884 [0.6311–0.7404], and 0.9802 [0.9631–0.9894], respectively. There were strong correlations between cCLNM and clinicopathologic characteristics. Ipsilateral central lymph node pathology is useful for predicting contralateral central compartment invasion in patients with thyroid cancer. In addition, clinicopathologic characteristics were associated with cCLNM in patients with unilateral thyroid cancer.

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KW - predictive value of tests

KW - prognosis

KW - thyroid neoplasm

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ER -

Predictive value of ipsilateral central lymph node metastasis for contralateral central lymph node metastasis in patients with thyroid cancer: Systematic review and meta-analysis

Abstract

Bibliographical note

Keywords

UN SDGs

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