Prevalence and clinical implications of painful diabetic peripheral neuropathy in type 2 diabetes: Results from a nationwide hospital-based study of diabetic neuropathy in Korea

Sang Soo Kim; Jong Chul Won; Hyuk Sang Kwon; Chong Hwa Kim; Ji Hyun Lee; Tae Sun Park; Kyung Soo Ko; Bong Yun Cha

doi:10.1016/j.diabres.2013.12.003

Prevalence and clinical implications of painful diabetic peripheral neuropathy in type 2 diabetes: Results from a nationwide hospital-based study of diabetic neuropathy in Korea

Sang Soo Kim
, Jong Chul Won
, Hyuk Sang Kwon
, Chong Hwa Kim
, Ji Hyun Lee
, Tae Sun Park
, Kyung Soo Ko
, Bong Yun Cha

Department of Internal Medicine

Pusan National University
Inje University
Sejong General Hospital
Catholic University of Daegu
Jeonbuk National University
The Catholic University of Korea

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

Aims: To determine the prevalence and risk factors for painful diabetic peripheral neuropathy (PDPN) and evaluate sleep impairment and quality of life in patients with PDPN. Methods: Data from the Korean Diabetes Association Neuropathy Study Group were used to evaluate 3999 patients with type 2 diabetes. PDPN was diagnosed using visual analogue scales (VAS) and medical history. The patients were asked to answer the Brief Pain Inventory-Short Form (BPI-SF), Medical Outcomes Study Sleep (MOS-Sleep) Scale, EuroQol (EQ-5D), and VAS. Results: Among the patients with diabetic peripheral neuropathy (n= 1338), 577 (43.1%) were diagnosed with PDPN (14.4% of all patients with type 2 diabetes). PDPN was independently associated with age, female gender, fasting plasma glucose, hypertension, and previous cerebrovascular events. All pain severity and interference measures were higher in patients with PDPN than in non-PDPN patients, and patients with PDPN reported more impaired sleep and lower EQ-5D and VAS scores. Conclusions: The prevalence of PDPN in Koreans was comparable to that in Western populations. PDPN may impair sleep and quality of life compared with non-PDPN, and physicians should carefully consider pain symptoms in patients with diabetic peripheral neuropathy.

Original language	English
Pages (from-to)	522-529
Number of pages	8
Journal	Diabetes Research and Clinical Practice
Volume	103
Issue number	3
DOIs	https://doi.org/10.1016/j.diabres.2013.12.003
State	Published - Mar 2014

Bibliographical note

Funding Information:
All authors declare they have no conflicts of interest. This study was sponsored by Pfizer Pharmaceuticals Korea Ltd. and supported by the Priority Research Centers Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology ( 2010-0020224 ). This work was also supported by the Inje Research and Scholarship Foundation in 2012 (J.C.W.). S.S.K. and J.C.W. collected data, contributed to discussions, and wrote and edited the manuscript. K.S.K. collected data, contributed to discussions, and reviewed the results. H.S.K., C.H.K., J.H.L., T.S.P., and B.Y.C. contributed to discussions and reviewed the results. K.S.K. is the guarantor of this work and, as such, had full access to all data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. We fully acknowledge the participating investigators in Korea and active members of the Korean Diabetic Neuropathy Study Group. We especially thank Professor Ki Jun Song (Department of Biostatistics, Yonsei University College of Medicine, Korea) for performing the statistical analysis and Hyo Jin Kim (Pfizer Pharmaceuticals Korea Ltd.) for assistance of study process.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Diabetic neuropathy
Pain
Painful diabetic peripheral neuropathy
Quality of life
Type 2 diabetes

Access to Document

10.1016/j.diabres.2013.12.003

Cite this

Kim, S. S., Won, J. C., Kwon, H. S., Kim, C. H., Lee, J. H., Park, T. S., Ko, K. S., & Cha, B. Y. (2014). Prevalence and clinical implications of painful diabetic peripheral neuropathy in type 2 diabetes: Results from a nationwide hospital-based study of diabetic neuropathy in Korea. Diabetes Research and Clinical Practice, 103(3), 522-529. https://doi.org/10.1016/j.diabres.2013.12.003

@article{fe226542cfd242c7be88be5c9a6ae7b5,

title = "Prevalence and clinical implications of painful diabetic peripheral neuropathy in type 2 diabetes: Results from a nationwide hospital-based study of diabetic neuropathy in Korea",

abstract = "Aims: To determine the prevalence and risk factors for painful diabetic peripheral neuropathy (PDPN) and evaluate sleep impairment and quality of life in patients with PDPN. Methods: Data from the Korean Diabetes Association Neuropathy Study Group were used to evaluate 3999 patients with type 2 diabetes. PDPN was diagnosed using visual analogue scales (VAS) and medical history. The patients were asked to answer the Brief Pain Inventory-Short Form (BPI-SF), Medical Outcomes Study Sleep (MOS-Sleep) Scale, EuroQol (EQ-5D), and VAS. Results: Among the patients with diabetic peripheral neuropathy (n= 1338), 577 (43.1\%) were diagnosed with PDPN (14.4\% of all patients with type 2 diabetes). PDPN was independently associated with age, female gender, fasting plasma glucose, hypertension, and previous cerebrovascular events. All pain severity and interference measures were higher in patients with PDPN than in non-PDPN patients, and patients with PDPN reported more impaired sleep and lower EQ-5D and VAS scores. Conclusions: The prevalence of PDPN in Koreans was comparable to that in Western populations. PDPN may impair sleep and quality of life compared with non-PDPN, and physicians should carefully consider pain symptoms in patients with diabetic peripheral neuropathy.",

keywords = "Diabetic neuropathy, Pain, Painful diabetic peripheral neuropathy, Quality of life, Type 2 diabetes",

author = "Kim, \{Sang Soo\} and Won, \{Jong Chul\} and Kwon, \{Hyuk Sang\} and Kim, \{Chong Hwa\} and Lee, \{Ji Hyun\} and Park, \{Tae Sun\} and Ko, \{Kyung Soo\} and Cha, \{Bong Yun\}",

note = "Funding Information: All authors declare they have no conflicts of interest. This study was sponsored by Pfizer Pharmaceuticals Korea Ltd. and supported by the Priority Research Centers Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology ( 2010-0020224 ). This work was also supported by the Inje Research and Scholarship Foundation in 2012 (J.C.W.). S.S.K. and J.C.W. collected data, contributed to discussions, and wrote and edited the manuscript. K.S.K. collected data, contributed to discussions, and reviewed the results. H.S.K., C.H.K., J.H.L., T.S.P., and B.Y.C. contributed to discussions and reviewed the results. K.S.K. is the guarantor of this work and, as such, had full access to all data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. We fully acknowledge the participating investigators in Korea and active members of the Korean Diabetic Neuropathy Study Group. We especially thank Professor Ki Jun Song (Department of Biostatistics, Yonsei University College of Medicine, Korea) for performing the statistical analysis and Hyo Jin Kim (Pfizer Pharmaceuticals Korea Ltd.) for assistance of study process. ",

year = "2014",

month = mar,

doi = "10.1016/j.diabres.2013.12.003",

language = "English",

volume = "103",

pages = "522--529",

journal = "Diabetes Research and Clinical Practice",

issn = "0168-8227",

publisher = "Elsevier Ireland Ltd",

number = "3",

}

Kim, SS, Won, JC, Kwon, HS, Kim, CH, Lee, JH, Park, TS, Ko, KS & Cha, BY 2014, 'Prevalence and clinical implications of painful diabetic peripheral neuropathy in type 2 diabetes: Results from a nationwide hospital-based study of diabetic neuropathy in Korea', Diabetes Research and Clinical Practice, vol. 103, no. 3, pp. 522-529. https://doi.org/10.1016/j.diabres.2013.12.003

Prevalence and clinical implications of painful diabetic peripheral neuropathy in type 2 diabetes: Results from a nationwide hospital-based study of diabetic neuropathy in Korea. / Kim, Sang Soo; Won, Jong Chul; Kwon, Hyuk Sang et al.
In: Diabetes Research and Clinical Practice, Vol. 103, No. 3, 03.2014, p. 522-529.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Prevalence and clinical implications of painful diabetic peripheral neuropathy in type 2 diabetes

T2 - Results from a nationwide hospital-based study of diabetic neuropathy in Korea

AU - Kim, Sang Soo

AU - Won, Jong Chul

AU - Kwon, Hyuk Sang

AU - Kim, Chong Hwa

AU - Lee, Ji Hyun

AU - Park, Tae Sun

AU - Ko, Kyung Soo

AU - Cha, Bong Yun

N1 - Funding Information: All authors declare they have no conflicts of interest. This study was sponsored by Pfizer Pharmaceuticals Korea Ltd. and supported by the Priority Research Centers Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology ( 2010-0020224 ). This work was also supported by the Inje Research and Scholarship Foundation in 2012 (J.C.W.). S.S.K. and J.C.W. collected data, contributed to discussions, and wrote and edited the manuscript. K.S.K. collected data, contributed to discussions, and reviewed the results. H.S.K., C.H.K., J.H.L., T.S.P., and B.Y.C. contributed to discussions and reviewed the results. K.S.K. is the guarantor of this work and, as such, had full access to all data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. We fully acknowledge the participating investigators in Korea and active members of the Korean Diabetic Neuropathy Study Group. We especially thank Professor Ki Jun Song (Department of Biostatistics, Yonsei University College of Medicine, Korea) for performing the statistical analysis and Hyo Jin Kim (Pfizer Pharmaceuticals Korea Ltd.) for assistance of study process.

PY - 2014/3

Y1 - 2014/3

N2 - Aims: To determine the prevalence and risk factors for painful diabetic peripheral neuropathy (PDPN) and evaluate sleep impairment and quality of life in patients with PDPN. Methods: Data from the Korean Diabetes Association Neuropathy Study Group were used to evaluate 3999 patients with type 2 diabetes. PDPN was diagnosed using visual analogue scales (VAS) and medical history. The patients were asked to answer the Brief Pain Inventory-Short Form (BPI-SF), Medical Outcomes Study Sleep (MOS-Sleep) Scale, EuroQol (EQ-5D), and VAS. Results: Among the patients with diabetic peripheral neuropathy (n= 1338), 577 (43.1%) were diagnosed with PDPN (14.4% of all patients with type 2 diabetes). PDPN was independently associated with age, female gender, fasting plasma glucose, hypertension, and previous cerebrovascular events. All pain severity and interference measures were higher in patients with PDPN than in non-PDPN patients, and patients with PDPN reported more impaired sleep and lower EQ-5D and VAS scores. Conclusions: The prevalence of PDPN in Koreans was comparable to that in Western populations. PDPN may impair sleep and quality of life compared with non-PDPN, and physicians should carefully consider pain symptoms in patients with diabetic peripheral neuropathy.

AB - Aims: To determine the prevalence and risk factors for painful diabetic peripheral neuropathy (PDPN) and evaluate sleep impairment and quality of life in patients with PDPN. Methods: Data from the Korean Diabetes Association Neuropathy Study Group were used to evaluate 3999 patients with type 2 diabetes. PDPN was diagnosed using visual analogue scales (VAS) and medical history. The patients were asked to answer the Brief Pain Inventory-Short Form (BPI-SF), Medical Outcomes Study Sleep (MOS-Sleep) Scale, EuroQol (EQ-5D), and VAS. Results: Among the patients with diabetic peripheral neuropathy (n= 1338), 577 (43.1%) were diagnosed with PDPN (14.4% of all patients with type 2 diabetes). PDPN was independently associated with age, female gender, fasting plasma glucose, hypertension, and previous cerebrovascular events. All pain severity and interference measures were higher in patients with PDPN than in non-PDPN patients, and patients with PDPN reported more impaired sleep and lower EQ-5D and VAS scores. Conclusions: The prevalence of PDPN in Koreans was comparable to that in Western populations. PDPN may impair sleep and quality of life compared with non-PDPN, and physicians should carefully consider pain symptoms in patients with diabetic peripheral neuropathy.

KW - Diabetic neuropathy

KW - Pain

KW - Painful diabetic peripheral neuropathy

KW - Quality of life

KW - Type 2 diabetes

UR - https://www.scopus.com/pages/publications/84898900573

U2 - 10.1016/j.diabres.2013.12.003

DO - 10.1016/j.diabres.2013.12.003

M3 - Article

C2 - 24438877

AN - SCOPUS:84898900573

SN - 0168-8227

VL - 103

SP - 522

EP - 529

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

IS - 3

ER -

Prevalence and clinical implications of painful diabetic peripheral neuropathy in type 2 diabetes: Results from a nationwide hospital-based study of diabetic neuropathy in Korea

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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