Prevention of chronic GVHD

Jong Wook Lee; H. Joachim Deeg

doi:10.1016/j.beha.2008.02.010

Prevention of chronic GVHD

Jong Wook Lee
, H. Joachim Deeg

Division of Hematology

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Chronic graft-versus-host disease (GVHD) is the most frequent late complication after hematopoietic-cell transplantation, and it has a major impact on quality of life and survival. As the pathophysiology is still incompletely understood, it has been difficult to design effective prophylactic regimens. However, prevention of acute GVHD appears to result in a lower incidence of chronic GVHD. The use of younger, non-allo-sensitized donors, preferentially of the same sex as the patient, and the use of stem cells other than peripheral-blood cells mobilized by granulocyte colony-stimulating factor (G-CSF), also are associated with a lower frequency of chronic GVHD. Furthermore, there are data to suggest that incorporation of thymoglobulin into the conditioning regimen is beneficial in reducing chronic GVHD and delayed complications.

Original language	English
Pages (from-to)	259-270
Number of pages	12
Journal	Best Practice and Research: Clinical Haematology
Volume	21
Issue number	2
DOIs	https://doi.org/10.1016/j.beha.2008.02.010
State	Published - Jun 2008

Bibliographical note

Funding Information:
This work is supported in part by grants HL36444 and CA18029 from the National Institutes of Health (NIH), Bethesda, MD, USA.

Keywords

Campath
PBPCs
acute GVHD
thymoglobulin

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10.1016/j.beha.2008.02.010

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title = "Prevention of chronic GVHD",

abstract = "Chronic graft-versus-host disease (GVHD) is the most frequent late complication after hematopoietic-cell transplantation, and it has a major impact on quality of life and survival. As the pathophysiology is still incompletely understood, it has been difficult to design effective prophylactic regimens. However, prevention of acute GVHD appears to result in a lower incidence of chronic GVHD. The use of younger, non-allo-sensitized donors, preferentially of the same sex as the patient, and the use of stem cells other than peripheral-blood cells mobilized by granulocyte colony-stimulating factor (G-CSF), also are associated with a lower frequency of chronic GVHD. Furthermore, there are data to suggest that incorporation of thymoglobulin into the conditioning regimen is beneficial in reducing chronic GVHD and delayed complications.",

keywords = "Campath, PBPCs, acute GVHD, thymoglobulin",

author = "Lee, \{Jong Wook\} and \{Joachim Deeg\}, H.",

note = "Funding Information: This work is supported in part by grants HL36444 and CA18029 from the National Institutes of Health (NIH), Bethesda, MD, USA. ",

year = "2008",

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doi = "10.1016/j.beha.2008.02.010",

language = "English",

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TY - JOUR

T1 - Prevention of chronic GVHD

AU - Lee, Jong Wook

AU - Joachim Deeg, H.

N1 - Funding Information: This work is supported in part by grants HL36444 and CA18029 from the National Institutes of Health (NIH), Bethesda, MD, USA.

PY - 2008/6

Y1 - 2008/6

N2 - Chronic graft-versus-host disease (GVHD) is the most frequent late complication after hematopoietic-cell transplantation, and it has a major impact on quality of life and survival. As the pathophysiology is still incompletely understood, it has been difficult to design effective prophylactic regimens. However, prevention of acute GVHD appears to result in a lower incidence of chronic GVHD. The use of younger, non-allo-sensitized donors, preferentially of the same sex as the patient, and the use of stem cells other than peripheral-blood cells mobilized by granulocyte colony-stimulating factor (G-CSF), also are associated with a lower frequency of chronic GVHD. Furthermore, there are data to suggest that incorporation of thymoglobulin into the conditioning regimen is beneficial in reducing chronic GVHD and delayed complications.

AB - Chronic graft-versus-host disease (GVHD) is the most frequent late complication after hematopoietic-cell transplantation, and it has a major impact on quality of life and survival. As the pathophysiology is still incompletely understood, it has been difficult to design effective prophylactic regimens. However, prevention of acute GVHD appears to result in a lower incidence of chronic GVHD. The use of younger, non-allo-sensitized donors, preferentially of the same sex as the patient, and the use of stem cells other than peripheral-blood cells mobilized by granulocyte colony-stimulating factor (G-CSF), also are associated with a lower frequency of chronic GVHD. Furthermore, there are data to suggest that incorporation of thymoglobulin into the conditioning regimen is beneficial in reducing chronic GVHD and delayed complications.

KW - Campath

KW - PBPCs

KW - acute GVHD

KW - thymoglobulin

UR - https://www.scopus.com/pages/publications/44049103664

U2 - 10.1016/j.beha.2008.02.010

DO - 10.1016/j.beha.2008.02.010

M3 - Review article

C2 - 18503991

AN - SCOPUS:44049103664

SN - 1521-6926

VL - 21

SP - 259

EP - 270

JO - Best Practice and Research: Clinical Haematology

JF - Best Practice and Research: Clinical Haematology

IS - 2

ER -

Prevention of chronic GVHD

Abstract

Bibliographical note

Keywords

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