Primary lymphoma of the prostate presented with gross hematuria

Primary lymphomas of the prostate are extremely rare and can mimic other more common prostatic lesions. We report a case of a primary diffuse large B-cell lymphoma of the prostate in a 59 years old man, who presented with lower urinary tract symptoms, gross hematuria and enlargement of the prostate on digital rectal examination. On microscopic examination, the tumor, composed of diffuse large cells, with B cell immunophenotypes, was diagnosed as a non-Hodgkin's lymphoma. After the histological diagnosis, the patient underwent 6 cycles of combination chemotherapy, with cyclophosphamide, doxorubicin, vincristine and prednisone, followed by involved-field radiation therapy. He is followed well for 5 months without any problem.