Primary ovarian dysfunction after hematopoietic stem cell transplantation during childhood: Busulfan-based conditioning is a major concern

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Abstract

We evaluated the incidence of patient/treatment factors associated with primary ovarian failure (POF) after hematopoietic stem cell transplantation (HSCT) during childhood. Fifty girls over 12 years of age (15.0±2.2) who were referred to the pediatric endocrinology clinic between March 2002 and March 2010 after HSCT at the Catholic HSCT center were enrolled in the study. In total, 36 (72%) out of 50 patients developed POF. Twenty-three patients were diagnosed and treated as chronic graft-versus-host disease. As preparative regimens for HSCT, 23 patients received total body irradiation (TBI)-based regimen, 19 received busulfan (BU)-based regimen, 4 received both BU-and TBI-based, and 4 received reduced intensity conditioning regimen. In a univariate logistic regression analysis, the BU-based regimen (p=0.028) showed a strong relationship with POF. The incidence of POF according to the route of BU administration, between orally and intravenously, were not different (p=0.435). These results emphasize the importance of monitoring these patients at regular intervals and the need to develop complementary HSCT protocols for preventing POF in children.

Original languageEnglish
Pages (from-to)1031-1035
Number of pages5
JournalJournal of Pediatric Endocrinology and Metabolism
Volume24
Issue number11-12
DOIs
StatePublished - 1 Dec 2011

Keywords

  • busulfan
  • hematopoietic stem cell transplantation
  • primary ovarian insufficiency

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